Another failed FET. Anyone do ERA even though you'd had one success before?

[Anonymous]

Hi... Just had another failed FET (frozen embryo transfer). My history is 3 failed clomud, 2 failed iui, 2 surgeries, ivf cycle with ohss and no transfer, 2 failed frozen transfers, 1 successful frozen transfer (my Dc), and now another failed frozen transfer. We don't know if our embryos are good because the lab that was supposed to do pgs had an accident and destroyed the DNA biopsies.

I have one frozen embryo left. I don't want to do an era (endometrial receptivity arrray) cycle if it would be pointless. No one seems to be sure whether someone who got pregnant before should get the test or not. I have enough frozen failures to qualify, but I also have DC. Does anyone here have any experience with era? Especially if you'd had a pregnancy before? I'm starting to think that my Dc happened in spite of a receptivity problem. A fluke. I don't know whether this is a promising road or one more thing I'd have to put my body through.

Tia.

[Anonymous]

I wouldn’t bother with ERA and would just do the FET. I don’t think your t captive day would change with childbirth or age.

[Anonymous]

Hi OP, I was able to get pregnant twice with clomid but when I had to do IVF, none of the embryo's took during three FETs. We weren't sure why b/c I had no trouble getting pregnant before. I was at SG at the time and they recommended an ERA but for various reasons I switched to GW where they did an EFT (endometrial function test). They found that everything was fine and did the transfer. It came back positive but ended in a CP. We just did another transfer and I'm six weeks pregnant so I highly recommend doing the test. I also think the protocol at GW was much better for me and my body.

Considering all the failed attempts you've gone through, I'd want to see if there's something else going on b/c what if the transfer needs to happen on a different day. If it comes back negative then that's a data point and you just lost a few months time but if it's positive and you need to adjust the timing then it may make all the difference in getting a positive pregnancy. Do you want to keep throwing money at FETs to just have it keep failing?

[Anonymous]

Pp I think you’re confusing the ERA biopsy. It’s a test that tells you what day you are receptive for transfer, ie day 7 instead of 6.

[Anonymous]

Anonymous wrote:Hi OP, I was able to get pregnant twice with clomid but when I had to do IVF, none of the embryo's took during three FETs. We weren't sure why b/c I had no trouble getting pregnant before. I was at SG at the time and they recommended an ERA but for various reasons I switched to GW where they did an EFT (endometrial function test). They found that everything was fine and did the transfer. It came back positive but ended in a CP. We just did another transfer and I'm six weeks pregnant so I highly recommend doing the test. I also think the protocol at GW was much better for me and my body.

Considering all the failed attempts you've gone through, I'd want to see if there's something else going on b/c what if the transfer needs to happen on a different day. If it comes back negative then that's a data point and you just lost a few months time but if it's positive and you need to adjust the timing then it may make all the difference in getting a positive pregnancy. Do you want to keep throwing money at FETs to just have it keep failing?

Thanks for your response. A couple of questions: eft doesn't seem to measure receptivity. Why did you choose that? It tests lots of things, but which mastered for your? Finally, did the test change your approach? My doctor said it's very unlikely someone who'd gotten pregnant via fet has a displaced window. I followed up to ask how unlikely--give me data. My body has been through enough. I am all for data and agree with you, but if it's basically a certainty that my window is normal, I don't want to go through it.

Really appreciate your time.

[Anonymous]

Stupid autocorrect. Should say "mattered for you". Sorry

[Anonymous]

I had a successful first FET, then a failed fresh transfer, then did an era that showed I needed an extra day of progesterone. Even though the first FET “worked” (miscarried at 9 weeks), the RE said that he thinks the window of implantation is wider than the ERA shows for some people, but after I did the extra day of progesterone on the second transfer it also “worked” (miscarried again at 8 weeks).

[Anonymous]

Anonymous wrote:Pp I think you’re confusing the ERA biopsy. It’s a test that tells you what day you are receptive for transfer, ie day 7 instead of 6.

I know what the ERA biopsy does. I was explaining that I ended up switching and doing a different test and could only speak for the EFT since I didn't do the ERA with my old clinic.

[Anonymous]

Anonymous wrote:

Anonymous wrote:Hi OP, I was able to get pregnant twice with clomid but when I had to do IVF, none of the embryo's took during three FETs. We weren't sure why b/c I had no trouble getting pregnant before. I was at SG at the time and they recommended an ERA but for various reasons I switched to GW where they did an EFT (endometrial function test). They found that everything was fine and did the transfer. It came back positive but ended in a CP. We just did another transfer and I'm six weeks pregnant so I highly recommend doing the test. I also think the protocol at GW was much better for me and my body.

Considering all the failed attempts you've gone through, I'd want to see if there's something else going on b/c what if the transfer needs to happen on a different day. If it comes back negative then that's a data point and you just lost a few months time but if it's positive and you need to adjust the timing then it may make all the difference in getting a positive pregnancy. Do you want to keep throwing money at FETs to just have it keep failing?

Thanks for your response. A couple of questions: eft doesn't seem to measure receptivity. Why did you choose that? It tests lots of things, but which mastered for your? Finally, did the test change your approach? My doctor said it's very unlikely someone who'd gotten pregnant via fet has a displaced window. I followed up to ask how unlikely--give me data. My body has been through enough. I am all for data and agree with you, but if it's basically a certainty that my window is normal, I don't want to go through it.

Really appreciate your time.

I switched to GW b/c after three failed FETs, SG just seemed to be guessing on what to do next. Plus the PIO injections were extremely painful for me and GW's protocol doesn't involve IM injections. GW thought the reason why the FET's failed was more of a lining issue, not with my progesterone levels. When looking at my hormone levels at SG, they were off the charts and GW's protocol is to mimic more of what your body is supposed to naturally produce. I don't have the stats in front of me but at SG my estrogen levels were as high as 3000 and GW wants them somewhere in the 300 range. I forget what my progesterone levels were but basically I was being pumped full of drugs and perhaps it was too much for my body and the pregnancy wouldn't take.

[Anonymous]

Anonymous wrote:I had a successful first FET, then a failed fresh transfer, then did an era that showed I needed an extra day of progesterone. Even though the first FET “worked” (miscarried at 9 weeks), the RE said that he thinks the window of implantation is wider than the ERA shows for some people, but after I did the extra day of progesterone on the second transfer it also “worked” (miscarried again at 8 weeks).

I'm sorry about your losses. Sadly, your experience doesn't answer whether the window is wider than era would like to say (seems it is), but more importantly whether your odds increase by being closer to what era suggests you do. Or if era is even meaningful/accurate. So frustrating for us all.

[Anonymous]

Anonymous wrote:

Anonymous wrote:I had a successful first FET, then a failed fresh transfer, then did an era that showed I needed an extra day of progesterone. Even though the first FET “worked” (miscarried at 9 weeks), the RE said that he thinks the window of implantation is wider than the ERA shows for some people, but after I did the extra day of progesterone on the second transfer it also “worked” (miscarried again at 8 weeks).

I'm sorry about your losses. Sadly, your experience doesn't answer whether the window is wider than era would like to say (seems it is), but more importantly whether your odds increase by being closer to what era suggests you do. Or if era is even meaningful/accurate. So frustrating for us all.

PP here that did ERA - I agree with you, but for what its worth my doctor told me (and seemed very confident) that the implantation timing (and therefore the ERA results) had nothing to do with the miscarriages. I'm not sure if I believe that as they were both PGS normals.