How much would you pay to avoid a miscarriage?

[Anonymous]

Is that essentially the value proposition of PGS?

I'm in the position now with severe DOR, age 35, 0.3 AMH and an AFC of 3.

A part of me just wants to do a few banking cycles and PGS the embryos to avoid the emotional roller coaster and heartache and time suck of miscarriages.

My RE strongly recommends against PGS as it costs a lot (everything is out of pocket for me) and she said I might not make enough day 5 embryos to test. Plus, mosaicism.

Anyone have experience here? The financial cost is high but what is the emotional cost of multiple miscarriages?

[Anonymous]

PGS is not the magic bullet. But we did pay around 15k to work with Dr. Braverman through a successful delivery (after three consecutive losses). So....I guess I'd say we'd pay several thousand to avoid a miscarriage. Our one embryo that was PGS tested resulted in BFN.

[Anonymous]

It was worth it for me to significantly lower the risk of miscarriage. Unfortunately, it does not rule out miscarriage and there have been several postings of women on this board that have miscarried PGS embryos. Putting aside the emotional cost of miscarriage, there are huge time sucks and set you back months in IVF. I'm surprised to hear your RE advised against it - mine at SGF and my OB at VHC - STRONGLY encourage it ( I was 34 w/PCOS). Was it discouraged specifically for you because of your DOR, or does the RE discourage it across the board? If it's the latter, that sounds usual and I'd suggest a second opinion.

[Anonymous]

Apart from miscarriage, the other value proposition is that you won't be transferring abnormal embryos that have no chance to implant (also time waster). And, if you bank enough, you "know what you have" if you want to have a second child.

[Anonymous]

REs and OBs underestimate the emotional cost of miscarriage and infertility since it is so normal for them, I think. My miscarriages screwed me up for years....the cost was much higher than PGS.

[Anonymous]

Anonymous wrote:PGS is not the magic bullet. But we did pay around 15k to work with Dr. Braverman through a successful delivery (after three consecutive losses). So....I guess I'd say we'd pay several thousand to avoid a miscarriage. Our one embryo that was PGS tested resulted in BFN.

Thanks for your experience... do you mean you worked with Dr. B about immune issues?

[Anonymous]

Anonymous wrote:It was worth it for me to significantly lower the risk of miscarriage. Unfortunately, it does not rule out miscarriage and there have been several postings of women on this board that have miscarried PGS embryos. Putting aside the emotional cost of miscarriage, there are huge time sucks and set you back months in IVF. I'm surprised to hear your RE advised against it - mine at SGF and my OB at VHC - STRONGLY encourage it ( I was 34 w/PCOS). Was it discouraged specifically for you because of your DOR, or does the RE discourage it across the board? If it's the latter, that sounds usual and I'd suggest a second opinion.

She said it's only recommended for patients over 40 or people with recurrent miscarriages. To be fair, I've never had a miscarriage and I have 2 kids (one IVF, one miracle baby). But the thought of having a miscarriage from an untested embryo (I have one) kind of terrifies me.

[Anonymous]

With DOR, it often doesn’t make sense to do PGS because you simply won’t have enough embryos. We did five rounds of IVF before age 35 and had one embryo to transfer between all those rounds. We didn’t test it and it was a BFN. Have you done IVF already? If not, I’m guessing the RE is making that suggestion based on her expectation that there will be few to no embryos. I would recommend doing IVF one, maybe two, times and seeing what your response is. If you aren’t getting embryos, move quickly on the DE. There is no other path for severe DOR. I went on to have three kids with donor eggs.

[Anonymous]

Anonymous wrote:With DOR, it often doesn’t make sense to do PGS because you simply won’t have enough embryos. We did five rounds of IVF before age 35 and had one embryo to transfer between all those rounds. We didn’t test it and it was a BFN. Have you done IVF already? If not, I’m guessing the RE is making that suggestion based on her expectation that there will be few to no embryos. I would recommend doing IVF one, maybe two, times and seeing what your response is. If you aren’t getting embryos, move quickly on the DE. There is no other path for severe DOR. I went on to have three kids with donor eggs.

Thanks. Knowing what I know now I wish I had banked when I was younger. My last IVF round (and only round) produced 3 embryos. I only had 4 eggs retrieved.

My RE is even skeptical I should do any more IVF with my numbers. She recommended IUI instead.

[Anonymous]

Anonymous wrote:

Anonymous wrote:It was worth it for me to significantly lower the risk of miscarriage. Unfortunately, it does not rule out miscarriage and there have been several postings of women on this board that have miscarried PGS embryos. Putting aside the emotional cost of miscarriage, there are huge time sucks and set you back months in IVF. I'm surprised to hear your RE advised against it - mine at SGF and my OB at VHC - STRONGLY encourage it ( I was 34 w/PCOS). Was it discouraged specifically for you because of your DOR, or does the RE discourage it across the board? If it's the latter, that sounds usual and I'd suggest a second opinion.

She said it's only recommended for patients over 40 or people with recurrent miscarriages. To be fair, I've never had a miscarriage and I have 2 kids (one IVF, one miracle baby). But the thought of having a miscarriage from an untested embryo (I have one) kind of terrifies me.

If you are 35 and have already had two kids, one without medical intervention, you do not have severe DOR. Just do IVF and transfer what you get.

[Anonymous]

Anonymous wrote:

Anonymous wrote:

She said it's only recommended for patients over 40 or people with recurrent miscarriages. To be fair, I've never had a miscarriage and I have 2 kids (one IVF, one miracle baby). But the thought of having a miscarriage from an untested embryo (I have one) kind of terrifies me.

That seems very conservative to me.

[Anonymous]

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:It was worth it for me to significantly lower the risk of miscarriage. Unfortunately, it does not rule out miscarriage and there have been several postings of women on this board that have miscarried PGS embryos. Putting aside the emotional cost of miscarriage, there are huge time sucks and set you back months in IVF. I'm surprised to hear your RE advised against it - mine at SGF and my OB at VHC - STRONGLY encourage it ( I was 34 w/PCOS). Was it discouraged specifically for you because of your DOR, or does the RE discourage it across the board? If it's the latter, that sounds usual and I'd suggest a second opinion.

She said it's only recommended for patients over 40 or people with recurrent miscarriages. To be fair, I've never had a miscarriage and I have 2 kids (one IVF, one miracle baby). But the thought of having a miscarriage from an untested embryo (I have one) kind of terrifies me.

If you are 35 and have already had two kids, one without medical intervention, you do not have severe DOR. Just do IVF and transfer what you get.

0.3 AMH and AFC of 3 isn't DOR?

[Anonymous]

Anonymous wrote:Is that essentially the value proposition of PGS?

I'm in the position now with severe DOR, age 35, 0.3 AMH and an AFC of 3.

A part of me just wants to do a few banking cycles and PGS the embryos to avoid the emotional roller coaster and heartache and time suck of miscarriages.

My RE strongly recommends against PGS as it costs a lot (everything is out of pocket for me) and she said I might not make enough day 5 embryos to test. Plus, mosaicism.

Anyone have experience here? The financial cost is high but what is the emotional cost of multiple miscarriages?

We paid PGS out of pocket as well after having a miscarriage. It was worth it for us, as we transferred a PGS normal embryo and I’m now 34 weeks pregnant.

[Anonymous]

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:It was worth it for me to significantly lower the risk of miscarriage. Unfortunately, it does not rule out miscarriage and there have been several postings of women on this board that have miscarried PGS embryos. Putting aside the emotional cost of miscarriage, there are huge time sucks and set you back months in IVF. I'm surprised to hear your RE advised against it - mine at SGF and my OB at VHC - STRONGLY encourage it ( I was 34 w/PCOS). Was it discouraged specifically for you because of your DOR, or does the RE discourage it across the board? If it's the latter, that sounds usual and I'd suggest a second opinion.

She said it's only recommended for patients over 40 or people with recurrent miscarriages. To be fair, I've never had a miscarriage and I have 2 kids (one IVF, one miracle baby). But the thought of having a miscarriage from an untested embryo (I have one) kind of terrifies me.

If you are 35 and have already had two kids, one without medical intervention, you do not have severe DOR. Just do IVF and transfer what you get.

0.3 AMH and AFC of 3 isn't DOR?

My RE and I consider it severe DOR (those are my numbers, too).

[Anonymous]

I don’t think I would do it without a history of miscarriage. PGS slightly damages the embryo. It’s often fine, but it does decrease the chance of successful implantation. This makes sense if you know there is a high chance of having abnormal embryos, but not as much if you are only worried about it in the absence of evidence. I would try at least one round and see what your response is first.