How many PGS normal before move on to FET?

[Anonymous]

I'm 42 and we've done several IVF cycles with PGS and now have 3 normal embryos frozen. Of course there are no guarantees, but trying to figure out if that's "enough" and to move on to transfer, or to do another cycle or two. Obviously better to do retrievals now than later, but also obviously want to move forward sooner rather than later too. How have others handled this?

[Anonymous]

Same here, 3 PGS normal. I transferred one and lost it after a month. I am doing more embryo banking, trying to get one more euploid embryo.

[Anonymous]

What is the reason to do embryo banking? Not sure why you wouldn’t proceed with FET.

[Anonymous]

You do embryo banking because if you are fortunate enough to get pregnant you lose a lot of months during pregnancy, and if you a) want more than one child, or b) have a late-term miscarriage or stillbirth, you've lost all that time...

OP, my RE told me for the best chance of each live birth we should plan to have 2-4 PGS normal embryos banked. At your age I understand why you'd want to try banking even one more and think it's probably worth it. I personally noticed a really precipitous drop-off between 42 and 43. I went from getting 5 PGS normal embryos out of two cycles down to four cycles with no normal embryos at all during that timeframe in my life, even though I was still making plenty of eggs (like, 13+ per ovary)...it was pretty shocking. Whatever you do, good luck (and to you, other PP with 3 normals)!

[Anonymous]

How badly do you want two children? If you would be happy to wind up with one, I’d go for the FET. If you think you’ll want two, I might do one more IVF. But no way to know!

[Anonymous]

Anonymous wrote:How badly do you want two children? If you would be happy to wind up with one, I’d go for the FET. If you think you’ll want two, I might do one more IVF. But no way to know!

Ummm, I am the PP who had 3 euploid embryos and lost 1. I am 41 going onto 42. I am banking embryos because I want at least one more euploid embryo since even with PGS things are not guaranteed at this age.

[Anonymous]

9:45 and 12:15 pp here. My RE says that he uses word euploid not word normal for PGS normal embryos. This means that they they have correct number/pair of chromosomes but that's the extent of it. PGS does not have capacity to uncover any other, non-chromosomal abnormalities.

[Anonymous]

Anonymous wrote:9:45 and 12:15 pp here. My RE says that he uses word euploid not word normal for PGS normal embryos. This means that they they have correct number/pair of chromosomes but that's the extent of it. PGS does not have capacity to uncover any other, non-chromosomal abnormalities.

I think we all know that when we say PGS normal, we are referring to chromosomes, and not any other things.

[Anonymous]

Anonymous wrote:

Anonymous wrote:9:45 and 12:15 pp here. My RE says that he uses word euploid not word normal for PGS normal embryos. This means that they they have correct number/pair of chromosomes but that's the extent of it. PGS does not have capacity to uncover any other, non-chromosomal abnormalities.

I think we all know that when we say PGS normal, we are referring to chromosomes, and not any other things.

You know but maybe others don't. It's good to discuss these things.

[Anonymous]

I did embryo banking at ages 34/35. Out of 19 blasts tested, I had 3 “normal” embryos and 1 that was inconclusive. I got pregnant on my first FET when I transferred one normal and the inconclusive. 3 years later, i transferred one more and had a chemical. A couple months later I transferred my last embryo. Currently 21w pregnant with Baby #2. Good luck.

[Anonymous]

Anonymous wrote:I did embryo banking at ages 34/35. Out of 19 blasts tested, I had 3 “normal” embryos and 1 that was inconclusive. I got pregnant on my first FET when I transferred one normal and the inconclusive. 3 years later, i transferred one more and had a chemical. A couple months later I transferred my last embryo. Currently 21w pregnant with Baby #2. Good luck.

Sorry about the loss in between. Congratulations on new pregnancy! I wish you well.

[Anonymous]

Anonymous wrote:I did embryo banking at ages 34/35. Out of 19 blasts tested, I had 3 “normal” embryos and 1 that was inconclusive. I got pregnant on my first FET when I transferred one normal and the inconclusive. 3 years later, i transferred one more and had a chemical. A couple months later I transferred my last embryo. Currently 21w pregnant with Baby #2. Good luck.

May I ask what your condition was? (unexplained, DOR, PCOS, etc)

[Anonymous]

Anonymous wrote:

Anonymous wrote:I did embryo banking at ages 34/35. Out of 19 blasts tested, I had 3 “normal” embryos and 1 that was inconclusive. I got pregnant on my first FET when I transferred one normal and the inconclusive. 3 years later, i transferred one more and had a chemical. A couple months later I transferred my last embryo. Currently 21w pregnant with Baby #2. Good luck.

May I ask what your condition was? (unexplained, DOR, PCOS, etc)

Unexplained. According to my RE’, my numbers were great - they said if I was younger they’d want me as an egg donor. DH and I had no problem producing “beautiful” day 5 embryos. After two failed fresh transfers, we did a freeze all cycle and had 11 blasts CGH tested. We were devastated when only one came back normal, after being told that statistically about 50% should be normal. . We did one more freeze all cycle and and had 8 blasts CGH tested. From that cycle we had 2 normals and 1 unexplained. After that we proceeded with our first FET, which was successful.

[Anonymous]

I would do more cycles to bank embryos now if you can afford it. I had 3 PGS normals at age 42 but unfortunately none took.

[Anonymous]

It also depends on what your resources are. Are you paying OOP, and how many more cycles can you finance, if you don't get a normal out of just one more cycle? You'll have to draw the line somewhere.

We got one normal in July at age 42. Insurance was covering unlimited retrievals (but only 3 transfers), so I did 3 more retrieval attempts and did not get any more normals (but like PP had lots of eggs). Insurance ended in December, and while we've paid OOP a couple years ago (got one normal on that cycle and it did not implant), we are not in a position to continue doing that. So that's it and we are stuck with the one moving forward. It sucks having everything riding on the one, but it is just what we were able to get.

I think the live birth rate is 50-60% per euploid embryo, so the above PP is right that if you really want 2 kids, you might try to get 4 embryos total.