natural cycle IVF

[Anonymous]

I've heard it mentioned frequently on this forum that natural cycle IVF "brings the best egg forward" but I'm having trouble understanding this. What is the mechanism that would make this happen? Isn't it the same egg that would come forward in an IUI or a stimulated IVF? I know you have the effect of stims on eggs with traditional IVF, but why would natural cycle IVF be any better than IUI, especially if you are not someone who needs ICSI? There are some real believers in the advantages and potential success of natural cycle for DOR, and I want to better understand the science behind this.

[Anonymous]

Because the sperm doesn't always meet the egg and fertilize with IUI. ICSI was basically required with NC IVF.

[Anonymous]

You're body supposedly knows to send the best egg forward-the leading follicle. I've had 2 early miscarriages despite a good reserve so one RE said it could be that my body for whatever reason unfortunately sends forward the wrong eggs. Who knows? am doing medicated ivf now with Pgd to try and overcome this-but that is a whole difft philosophy since they bring all the eggs up (suppressing the leading follicle) so they can maximize harvest amount. In fact my lead egg was likely sacrificed as it got too big too fast and they wanted to let the lagging majority get bigger. I've read women, esp those who are ama or dor worry about doing this, as they might be sacrificing the quality for quantity. SG disputes this saying the highest ivf success rates correlate with the highest number of eggs retrieved, and that's why the success rate for natural ivf is therefore low (see their webpage on But dor/ama patients have said specialized clinics have recommended lower stims to emphasize quality, so that seems to be closer to the natural ivf strategy. Not an expert, this is mostly my conjecture. Hope that helps.

[Anonymous]

Anonymous wrote:You're body supposedly knows to send the best egg forward-the leading follicle. I've had 2 early miscarriages despite a good reserve so one RE said it could be that my body for whatever reason unfortunately sends forward the wrong eggs. Who knows? am doing medicated ivf now with Pgd to try and overcome this-but that is a whole difft philosophy since they bring all the eggs up (suppressing the leading follicle) so they can maximize harvest amount. In fact my lead egg was likely sacrificed as it got too big too fast and they wanted to let the lagging majority get bigger. I've read women, esp those who are ama or dor worry about doing this, as they might be sacrificing the quality for quantity. SG disputes this saying the highest ivf success rates correlate with the highest number of eggs retrieved, and that's why the success rate for natural ivf is therefore low (see their webpage on But dor/ama patients have said specialized clinics have recommended lower stims to emphasize quality, so that seems to be closer to the natural ivf strategy. Not an expert, this is mostly my conjecture. Hope that helps.

It's not SG, it's the current medical research that says that. However, it's true that lower dose protocols can be helpful for DOR/AMA, but not becaues they produce fewer and better eggs. I had more eggs on lower dose protocol than on high. The quality was marginally better.

[Anonymous]

Anonymous wrote:

Anonymous wrote:You're body supposedly knows to send the best egg forward-the leading follicle. I've had 2 early miscarriages despite a good reserve so one RE said it could be that my body for whatever reason unfortunately sends forward the wrong eggs. Who knows? am doing medicated ivf now with Pgd to try and overcome this-but that is a whole difft philosophy since they bring all the eggs up (suppressing the leading follicle) so they can maximize harvest amount. In fact my lead egg was likely sacrificed as it got too big too fast and they wanted to let the lagging majority get bigger. I've read women, esp those who are ama or dor worry about doing this, as they might be sacrificing the quality for quantity. SG disputes this saying the highest ivf success rates correlate with the highest number of eggs retrieved, and that's why the success rate for natural ivf is therefore low (see their webpage on But dor/ama patients have said specialized clinics have recommended lower stims to emphasize quality, so that seems to be closer to the natural ivf strategy. Not an expert, this is mostly my conjecture. Hope that helps.

It's not SG, it's the current medical research that says that. However, it's true that lower dose protocols can be helpful for DOR/AMA, but not becaues they produce fewer and better eggs. I had more eggs on lower dose protocol than on high. The quality was marginally better.

I also had more eggs on lower dosages. I went from 8-12 eggs on 225/Menopur and 450/Follistim versus 25 eggs on 75/Menopur and 150/Follistim (plus Clomid).

[Anonymous]

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:You're body supposedly knows to send the best egg forward-the leading follicle. I've had 2 early miscarriages despite a good reserve so one RE said it could be that my body for whatever reason unfortunately sends forward the wrong eggs. Who knows? am doing medicated ivf now with Pgd to try and overcome this-but that is a whole difft philosophy since they bring all the eggs up (suppressing the leading follicle) so they can maximize harvest amount. In fact my lead egg was likely sacrificed as it got too big too fast and they wanted to let the lagging majority get bigger. I've read women, esp those who are ama or dor worry about doing this, as they might be sacrificing the quality for quantity. SG disputes this saying the highest ivf success rates correlate with the highest number of eggs retrieved, and that's why the success rate for natural ivf is therefore low (see their webpage on But dor/ama patients have said specialized clinics have recommended lower stims to emphasize quality, so that seems to be closer to the natural ivf strategy. Not an expert, this is mostly my conjecture. Hope that helps.

It's not SG, it's the current medical research that says that. However, it's true that lower dose protocols can be helpful for DOR/AMA, but not becaues they produce fewer and better eggs. I had more eggs on lower dose protocol than on high. The quality was marginally better.

I also had more eggs on lower dosages. I went from 8-12 eggs on 225/Menopur and 450/Follistim versus 25 eggs on 75/Menopur and 150/Follistim (plus Clomid).

PP - when in the cycle did you take Clomid and what did you trigger with?

[Anonymous]

Do higher success rates correlate with higher number of eggs retrieved across the board, or only in women who aren't AMA/DOR? PP, you had more eggs on lower dose stims--was the quality any different?