FET success transferring 7 days past ovulation instead of 5?

[Anonymous]

I've had 3 FET's with PGS tested embryos that all failed to implant. Endometrial biopsy revealed no problems with my uterus so there's no clear explanation for why implantation isn't happening. I had decided to give up figuring that IVF just doesn't work for everyone but my doctor suggested one last try. He wants to transfer 7 days past ovulation instead of 5 days past as we had been doing. He said some patients with recurrent implantation failiure need to delay the ET for 2 additional days to allow for the implantation window to mature. Has anyone else tried this and if so, what was the outcome? Thanks!

[Anonymous]

Check the "ERA Biopsy" thread.

[Anonymous]

Thank you! I just read it, looks like I'll have to wait a bit longer to see what the outcome is. Hopefully seven days past ovulation is the answer for those posters and for me as well.

[Anonymous]

I would get the ERA biopsy done. I believe some women need an extra day of progesterone and some even need 2 extra days. I think I read that 25% of the ppl who have the test done come back as pre receptive (need more progesterone)

[Anonymous]

Have you had an HSG recently? Within the last 6 months? I agree that your implantation window could be off but checking to be sure you don't have any blockages in your tubes is important. Over time, things can change in there - speaking from experience with failed PGS embryos...and now a 28 week pregnancy on the way. I had not had a repeat HSG since having baby #1.

[Anonymous]

I would definitely get the implantation window biopsy (ERA or Yale EFT). I had 3 failures with CGH normal DE embryos on the standard estrogen / progesterone protocol. I thought the artificial estrogen / progesterone might be messing with my implantation. I did the EFT test based on a natural cycle: no estrogen and just progesterone suppositories. EFT was normal on the natural cycle, so we did my next transfer with a natural cycle protocol - transfer on day 5. I finally got a pregnancy that has stuck (so far to 20 weeks), but even then I seemed to be a late implanter. The urine FR response tests that had always been reliable in the past for me showed negatives. I didn't go in for my beta until late, but it was finally positive.

Also you should think about making sure your Vitamin D levels are normal, think about immune testing and treatment (at least prednisone), check for any clotting disorders, and make sure your TSH is below 1, and then re-check at the time of the beta as it can rise rapidly.

[Anonymous]

Also, as to PP, if she is transferring frozen embryos, it doesn't matter if her tubes are blocked -- unless she is doing a natural cycle. Though you might want to do a saline sono to make sure that you don't have any polyps in your uterus. That can change over time -- even within 6 months.

[Anonymous]

OP here. Thank you all for your replies. I had an HSG done that was normal but it was a while ago so maybe I need another one. I had a total thyroidectomy done in 2010 so I check my TSH regularly. Unfortunately, I learned how this can affect pregnancy too late. When I became pregnant naturally in 2013, my obgyn told me that I didn't need to change my synthroid dose for a while so I didn't have my levels checked until 8 weeks and by that time my TSH had spiked and we lost a heartbeat two weeks later. I started seeing a new endocrinologist when I began doing IVF and she keeps a close eye on my levels now. To the poster who mentioned natural cycle, I found it interesting that you supplemented with progesterone only, I asked about doing that but was told their protocol is to use both estrogen and progesterone. All along I have been doing "natural cycle" FET's, but once I ovulate, they said I had to take estrogen and progesterone until the beta. They're checking my E2 levels during monitoring and on the day of transfer so I guess they must feel I need the estradiol but I always hate taking it because it can bind to T4 (synthroid) and on my 2nd failed FET, my TSH went from 1 to 17 after just 10 days of estradiol. Now I have to increase my Synthroid as soon as I start taking it and check my TSH every week.