Any fellow DOR/low AMH/high FSH/ AMA
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Anonymous
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Seems I qualify for all the above labels ... Anybody else share these labels? If yes, what protocol have you tried? So far I tried two antagonist protocols with BFN ... second cycle needed higher dose of meds .. stimmed longer... I'm afraid how this third cycle is going to be... Haven't had my baseline yet ... |
Anonymous
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I had all of these labels except AMA. Tried 5 cycles of IVF with different protocols, all involving very high doses of Follistim/Gonal-F. I never got more than one egg at retrieval. A few chemical pregnancies and one miscarriage at 6 weeks that was a blighted ovum.
I did DE IVF and got pregnant twice on the first try. I am about to deliver baby #2. With this diagnosis, I would recommend moving to DE sooner rather than later if you are open to it. I wish I had done it sooner. |
Anonymous
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All of those, but normal FSH. Microflare lupron worked at 38 but didn't work at 40.
I agree with REs that a protocol serves only to get you to retrieval, and ideally, they will get something out of each follicle. The rest has little to do with protocol. For AMAs, it's mostly the quality issue (<10% of our eggs are good enough to begin with, and those only have about 40% implantation rate). |
Anonymous
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I am all of those as well. I've done estrogen priming with gonal f, menopur, ganirlex, (high stims). I've done cycles with lupron-all the same outcome-one egg. I have tried natural cycle IVF and also got one egg, although it ended up being the best quality I've ever had. Unfortunately, did not work, but if you haven't tried it yet (Natural IVF), I'd give it a chance.
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Anonymous
| Check out this forum for ladies with high FSH, it may be helpful to you: http://www.network54.com/Forum/53068/ |
Anonymous
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AMH of <.01 and 5 follicles at my AFC. I did NC IVF which worked on the first try.
With my first, 3 years earlier, I had AMH of .30, and had 3 failed IUIs. Got pregnant naturally while waiting to start IVF. |
Anonymous
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I'm all of those. I don't remember the protocols I used on my 2 OE IVF. But I got 2 eggs on the first cycle, both 3dt--BFN. The next cycle I got 3 eggs, but none made it to transfer.
Moved on to Shared Risk DE-wish I had moved on sooner! |
Anonymous
| I would move away from antagonist protocols. The high dose of meds "fries" the eggs and results in poor quality. Look into natural cycle IVF or estrogen priming protocol. |
Anonymous
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Op here. Thank you for all your responses. I'm not ready for DE just yet. I'm not ready mentally/emotionally and I haven't explored financially but i know it would be pricey. I'm trying locally, although I have considered going to the big out of state clinics. This third IVF will be EPP, antagonist protocol seemed to get bad really quickly (second ivf was longer, stronger dose), also AMH decreased considerably, so RE suggested the EPP. It seems a it's a very very long protocol.... I have read that stims can take long (12 days or more) but eggs are 'protected' so they don't fry. so here's to hoping! Best of luck to fellow DOR's. |
Anonymous
| I had all of these too. Go see Dr Davis at Cornell. Seriously he is the best for DOR. |
Anonymous
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I totally understand not being ready for DE. Most of us also had to try everything before being ready. And once you are over that hump, you can't believe you waited so long.
Just make sure you have enough money left over from IVF to move on to DE or Adoption. Shady Grove Shared Risk DE 3:1 $29,000 2:1 or frozen eggs $39,000 1:1 $49,000 But meds are super cheap (like $300 per cycle) |
Anonymous
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All of the above. Used diet and acupuncture to lower my FSH and got pregnant spontaneously 3 times. Final time resulted in my 14 week old. several failed IUIs and NC IVF. My last NC had a beautiful AA embryo but BFN.
Good luck! It is a tough diagnosis to swallow. If you continue to also try the old fashioned way, do not skip a month- even when, especially when sex feels like a chore. |
Anonymous
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I am all of the above. Plus I have a very low AFC.
I did microdose flare for my first cycle. Was cancelled on day 10 of stims due to poor response (one lead follicle and only two other small ones). I am on my second cycle now and currently on day 12 of stims (follistim, menopur and cetrotide). Doing EPP antagonist protocol. I grew quickly the ten days and have nine follicles. But by yesterday things started to slow down. My doctor increased the dose of both follistim and menopur to "try to get a boost" but I am quite worried that the high doses have really sacrificed quality. I will likely trigger tomorrow for Saturday retrieval. I have already met with a new doctor and will be switching from my currently clinic to another when this cycle is over. The new RE will be doing a totally different protocol (he was very surprised I was doing the two that I am). |
Anonymous
Can you share your protocol? I'll be doing EPP but haven't started yet, so I do not know my protocol, except that would include follitism and cetrotide (no menopur). What other protocol was suggested by your new ER? Isn't EPP indicated for DOR? I don't understand why new RE was so surprised. |
Anonymous
He never does microdose Lupron as he said in his experience it a) doesn't always prevent ovulation and b) the flare effect isn't high enough to get a benefit. He does use EPP but with a longer estridol priming period than I did with my current RE. He also doesn't use Menopur and a much lower dose of Follistim. And he uses the antagonist throughout the cycle, not just when the follicles reach a certain size. |