"I am a geneticist myself (although prenatal screening is not my specialty) and at the time I did a ton of reading on PAPP-A, because I wanted to know why my values were so low when I had a normal baby. It turns out low PAPP-A can indicate problems other than Downs Syndrome, namely, it can be an indication of poor blood vessel development in the placenta. This can lead to slow growth in the third trimester and low birth weight. I discussed this with my OB, and she suggested that we do an ultrasound at the beginning of the third trimester to get an indication of the baby's size, and then follow-up ultrasounds every 2-3 weeks thereafter to track growth. In my case, baby's growth was fine, but I had very low amniotic fluid levels which led to an early C-section. Low fluid can also be caused by placenta problems. "
Same experience. I had severe PE twice and very low PAPP-A both times. My MFM said there is definetely a correlation but not strong enough on its own to be a screening test for PE issues.
|