Transfer 1 or 2 PGS normal at41?

[Anonymous]

I just cycled with CCRM and had to make the same decision.

I left it up to Dr. Schoolcraft, and he recommended transferring 2 because we had Day 6 blasts.

The were both CCS normal, and we took his recommendation.

We are currently 20 weeks pregnant with twins.

Even though we knew the risk, it is still a shock. I worry about our health (I had pre-eclampsia with my daughter), but am taking it one day at a time.

Good luck to you!

[Anonymous]

Anonymous wrote:No advice on this, but I'm curious if there was anything special that allowed you to achieve 4 PGS normals at age 41. And it sounds like you had more than one PGS normal recently with CFA. To get even one PGS normal at 41 is extremely fortunate. What was your protocol at both places?

I'm PP here, also wondering if CFA tested you for immune issues. Sounds like you had more than one unsuccessful FET of PGS normal embryos there.

[Anonymous]

Anonymous wrote:The stats are better for two (~55% vs 85%)
I had the same situation at 41 & transferred one however per my RE's recommendation
He was giving me the same stats as someone younger and we both agreed that I wasn't a good candidate for twins given my age and other factors
And it worked out but I knew I was decreasing my likelihood of success
This is very personal decision OP and I would push your RE to give you a success rate with one versus two

Is that the case for PGS tested embryos? (Not a math whiz.)

[Anonymous]

To answer PP....Yes, the stats are for PGS tested normal embryos. You should ask your RE because it varies by person.

[Anonymous]

Anonymous wrote:

Anonymous wrote:No advice on this, but I'm curious if there was anything special that allowed you to achieve 4 PGS normals at age 41. And it sounds like you had more than one PGS normal recently with CFA. To get even one PGS normal at 41 is extremely fortunate. What was your protocol at both places?

I'm PP here, also wondering if CFA tested you for immune issues. Sounds like you had more than one unsuccessful FET of PGS normal embryos there.

OP here. So sorry to the PP on losing her twins. I can't even imagine what she's been through.

Someone asked about my protocol at CCRM. It was the first time I've done an estrogen priming protocol. I stimmed with menopur & follistim. My 2 fresh cycles at CFA were at ages 33 & 36 and neither produced as many eggs or embryos as the CCRM cycle at age 41. I didn't do PGS testing at CFA. At CFA my fresh transfers were successful but then each time only 1 or 2 made it to blast to freeze and the FETs from these were always negative. Dr. schoolcraft doesn't think it's an immune issue so much as those embryos probably would not have tested normal. I stimmed for longer & at lower doses at CCRM. Not sure if it's that, the estrogen priming or the CCRM lab that has made the biggest difference this cycle?

Thanks for everyone's advice on transferring 1 vs 2. I am going to go with 1.

[Anonymous]

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:No advice on this, but I'm curious if there was anything special that allowed you to achieve 4 PGS normals at age 41. And it sounds like you had more than one PGS normal recently with CFA. To get even one PGS normal at 41 is extremely fortunate. What was your protocol at both places?

I'm PP here, also wondering if CFA tested you for immune issues. Sounds like you had more than one unsuccessful FET of PGS normal embryos there.

OP here. So sorry to the PP on losing her twins. I can't even imagine what she's been through.

Someone asked about my protocol at CCRM. It was the first time I've done an estrogen priming protocol. I stimmed with menopur & follistim. My 2 fresh cycles at CFA were at ages 33 & 36 and neither produced as many eggs or embryos as the CCRM cycle at age 41. I didn't do PGS testing at CFA. At CFA my fresh transfers were successful but then each time only 1 or 2 made it to blast to freeze and the FETs from these were always negative. Dr. schoolcraft doesn't think it's an immune issue so much as those embryos probably would not have tested normal. I stimmed for longer & at lower doses at CCRM. Not sure if it's that, the estrogen priming or the CCRM lab that has made the biggest difference this cycle?

Thanks for everyone's advice on transferring 1 vs 2. I am going to go with 1.

I wondered if the lab was part of my problem and switched from a small clinic to Shady Grove and did not see improvement in embryos making it to blast. Maybe it was estrogen priming and lower dose. Were you on any supplements for any period beforehand? Glad you've made a decision you feel good about.

[Anonymous]

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:No advice on this, but I'm curious if there was anything special that allowed you to achieve 4 PGS normals at age 41. And it sounds like you had more than one PGS normal recently with CFA. To get even one PGS normal at 41 is extremely fortunate. What was your protocol at both places?

I'm PP here, also wondering if CFA tested you for immune issues. Sounds like you had more than one unsuccessful FET of PGS normal embryos there.

OP here. So sorry to the PP on losing her twins. I can't even imagine what she's been through.

Someone asked about my protocol at CCRM. It was the first time I've done an estrogen priming protocol. I stimmed with menopur & follistim. My 2 fresh cycles at CFA were at ages 33 & 36 and neither produced as many eggs or embryos as the CCRM cycle at age 41. I didn't do PGS testing at CFA. At CFA my fresh transfers were successful but then each time only 1 or 2 made it to blast to freeze and the FETs from these were always negative. Dr. schoolcraft doesn't think it's an immune issue so much as those embryos probably would not have tested normal. I stimmed for longer & at lower doses at CCRM. Not sure if it's that, the estrogen priming or the CCRM lab that has made the biggest difference this cycle?

Thanks for everyone's advice on transferring 1 vs 2. I am going to go with 1.

I wondered if the lab was part of my problem and switched from a small clinic to Shady Grove and did not see improvement in embryos making it to blast. Maybe it was estrogen priming and lower dose. Were you on any supplements for any period beforehand? Glad you've made a decision you feel good about.

I really do think CCRM's lab is drastically better. Look at their donor egg stats! I was on one supplement that I purchased there as part of a clinical trial for acai. It is supposed to improve egg quality.

[Anonymous]

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:No advice on this, but I'm curious if there was anything special that allowed you to achieve 4 PGS normals at age 41. And it sounds like you had more than one PGS normal recently with CFA. To get even one PGS normal at 41 is extremely fortunate. What was your protocol at both places?

I'm PP here, also wondering if CFA tested you for immune issues. Sounds like you had more than one unsuccessful FET of PGS normal embryos there.

OP here. So sorry to the PP on losing her twins. I can't even imagine what she's been through.

Someone asked about my protocol at CCRM. It was the first time I've done an estrogen priming protocol. I stimmed with menopur & follistim. My 2 fresh cycles at CFA were at ages 33 & 36 and neither produced as many eggs or embryos as the CCRM cycle at age 41. I didn't do PGS testing at CFA. At CFA my fresh transfers were successful but then each time only 1 or 2 made it to blast to freeze and the FETs from these were always negative. Dr. schoolcraft doesn't think it's an immune issue so much as those embryos probably would not have tested normal. I stimmed for longer & at lower doses at CCRM. Not sure if it's that, the estrogen priming or the CCRM lab that has made the biggest difference this cycle?

Thanks for everyone's advice on transferring 1 vs 2. I am going to go with 1.

I wondered if the lab was part of my problem and switched from a small clinic to Shady Grove and did not see improvement in embryos making it to blast. Maybe it was estrogen priming and lower dose. Were you on any supplements for any period beforehand? Glad you've made a decision you feel good about.

I really do think CCRM's lab is drastically better. Look at their donor egg stats! I was on one supplement that I purchased there as part of a clinical trial for acai. It is supposed to improve egg quality.

Just curious--I looked at taking acai a while back but could never figure out how much to take. Do you know how much acai was in your supplement?

[Anonymous]

Good luck OP. I hope you get to share good news with us in a few weeks!

[Anonymous]

Any updates OP? What happened? I'm faced with your exact choice right now and trying to decide what to do.

[Anonymous]

1

[Anonymous]

Anonymous wrote:Any updates OP? What happened? I'm faced with your exact choice right now and trying to decide what to do.

The chances of twins are VERY high with two PGS-tested embryos. Depends if you want to risk twins. If not, just do one at a time. Especially if it's your first pregnancy.

[Anonymous]

Anonymous wrote:

Anonymous wrote:Any updates OP? What happened? I'm faced with your exact choice right now and trying to decide what to do.

The chances of twins are VERY high with two PGS-tested embryos. Depends if you want to risk twins. If not, just do one at a time. Especially if it's your first pregnancy.

Not if you have issues with implantation.

[Anonymous]

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:Any updates OP? What happened? I'm faced with your exact choice right now and trying to decide what to do.

The chances of twins are VERY high with two PGS-tested embryos. Depends if you want to risk twins. If not, just do one at a time. Especially if it's your first pregnancy.

Not if you have issues with implantation.

This is true but presumably your RE is addressing those in concert with testing the embryos.

[Anonymous]

I would do 1. Obviously this is a personal choice, but I have seen too many sets of twins that were born prematurely, and a number of them have resulting health issues or developmental delays. However, you should go with your gut in this instance.