Urologist for DNA fragmentation test in DC

[Anonymous]

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:GW Fertility poo pooed DNA fragmentation, but after 3 failed cycles with them, we want to get fragmentation checked at least. Looking for recommendations for a urologist in DC that will test for DNA fragmentation. MFI is 1% morph and post-wash count ranges from 1-5 million usually, though we did ICSI for IVF.

We went around and around and around with GW about this. We ended up doing the DNA frag test on our own after 5 failed rounds of IVF (4 at GW) and the results came back showing high frag and GW still will not listen to our concerns about it being male factor. It’s incredibly frustrating. Bottom line, you’ll probably need to move to a different clinic for help with this.

Wow this is so frustrating! Can I ask what your results looked like? Low fertilization rates? Or normal fertilization rates and failed transfers? Something else? We have only one failed round at gw but they aren’t recommending further testing for my husband which I don’t understand. I think our fertilization rate with ICSI was low (60%), but they say it’s fine.

Lots of eggs, good fert rate, but most of the embryos arrested around Day 3. We managed to get 6 blasts over the 4 cycles, but all were PGS abnormal.

Wow this was is too except we didn’t do pgs. When it happened with donor eggs too we did a frag test and it was normal. Unfortunately, we decided to stop because it seemed like there is unexplained me factor and we were getting older than we wanted to be for having a baby. P

[Anonymous]

Anonymous wrote:Dr. Dean. Also, I think my situation is different than yours. All my embryos over multiple cycles at different centers arrested after day 3, which is very different than six blasts over four cycles. Also, to be fair, none of the centers I've been to, have been able to Diagnose anything other than mf, but I have a lot of failures. The advice is to just keep doing icsi. I don't know if tese will make a difference, but it's something new instead of same old failures.

But it was 6 blasts over 4 cycles where I retrieved 60 eggs and had about 50 embryos. GW told me the same thing - that if it was a MF issue then ALL would have failed around Day 3 and I would not have gotten the 6 blasts. That just doesn’t make sense to me. It’s not all or nothing. Is it EVER all or nothing in IVG?

[Anonymous]

I have the same issue. Currently completed egg retrieval at CCRM. 33 retrieved, 19 mature, 12 fertilized with ICSI, 4 embryos, the last one only made it to blast on day 7. All were going strong on day 3. So far we are unexplained but my husband's morphology is 2%. Looking for a urologist who will order DNA fragmentation. Can we order it ourselves? I've read the zymot chip may help but it's still so new, not sure if any doctor will consider it. We are both 33, about to turn 34.

I hate that doctors are reluctant to even consider male factor when CCRM Colorado own research supports that DNA frag can definitely impact blast rates.

[Anonymous]

I would like to keep this conversation going. We did two cycles at CCRM - we had very good maturation rates, mediocre fertilization rates (first round about 50%, second round about 65%) and then no blasts both rounds. The first round it was clear on day 3 that none were going to make it. Our second round we got closer to blasts... we had 3 that were looking better on day 5, but did not end up making it. We're trying another round at SGF right now while simultaneously looking into fragmentation and MF issues.

[Anonymous]

Please keep us updated with your results at shady grove? Was ccrm open to testing dna fragmentation? I switched from shady grove because I read that ccrm had a better lab. I’m not sure if this is true for nova or only the flagship clinic in Colorado.

[Anonymous]

Anonymous wrote:I would like to keep this conversation going. We did two cycles at CCRM - we had very good maturation rates, mediocre fertilization rates (first round about 50%, second round about 65%) and then no blasts both rounds. The first round it was clear on day 3 that none were going to make it. Our second round we got closer to blasts... we had 3 that were looking better on day 5, but did not end up making it. We're trying another round at SGF right now while simultaneously looking into fragmentation and MF issues.

Okay we heard back from Shady Grove this weekend. Happy to share that we have 3 blasts. I’ll give our history, in case it helps. I’m 30 and husband is 38. He has some lower numbers, but nothing shocking so on paper we should have had a fairly straightforward case.

Spring 2019: CCRM Round 1- 11 retrieved, 10 matured, 5 fertilized, 0 blasts.
Summer 2019: husband has varicoceles repaired
Fall 2019: CCRM round 2- 18 retrieved, 17 matured, 8 fertilized, 0 blast

We had some concerns w the organization of CCRM with a few instances of mistakes happening (a nurse told me the wrong medicine amount and I questioned it and I was correct, for example). Our doc at CCRM also pushed for donor sperm after the first cycle which we felt was premature. We decided to try shady grove and saw Dr Widra at K St.

Winter 2020 at Shady Grove - 20 retrieved, 13 matured, 8 fertilized, 3 blasts.

Fingers crossed for normal embryos but even making a blastocyst has been the biggest motivator. Some rare good news we’ve heard in our ivf journey.

[Anonymous]

Anonymous wrote:

Anonymous wrote:I would like to keep this conversation going. We did two cycles at CCRM - we had very good maturation rates, mediocre fertilization rates (first round about 50%, second round about 65%) and then no blasts both rounds. The first round it was clear on day 3 that none were going to make it. Our second round we got closer to blasts... we had 3 that were looking better on day 5, but did not end up making it. We're trying another round at SGF right now while simultaneously looking into fragmentation and MF issues.

Okay we heard back from Shady Grove this weekend. Happy to share that we have 3 blasts. I’ll give our history, in case it helps. I’m 30 and husband is 38. He has some lower numbers, but nothing shocking so on paper we should have had a fairly straightforward case.

Spring 2019: CCRM Round 1- 11 retrieved, 10 matured, 5 fertilized, 0 blasts.
Summer 2019: husband has varicoceles repaired
Fall 2019: CCRM round 2- 18 retrieved, 17 matured, 12 fertilized, 0 blast (we had 12 fertilized here...i typed this wrong originally)

We had some concerns w the organization of CCRM with a few instances of mistakes happening (a nurse told me the wrong medicine amount and I questioned it and I was correct, for example). Our doc at CCRM also pushed for donor sperm after the first cycle which we felt was premature. We decided to try shady grove and saw Dr Widra at K St.

Winter 2020 at Shady Grove - 20 retrieved, 13 matured, 8 fertilized, 3 blasts.

Fingers crossed for normal embryos but even making a blastocyst has been the biggest motivator. Some rare good news we’ve heard in our ivf journey.