FET protocol at SG

[Anonymous]

In contrast, the live birth rate for frozen embryo transfers supported only by vaginal endometrin administration was 40 percent lower than that of cycles including IMP (28.6 percent live birth for endometrin only versus 47.3 percent live birth for daily IMP or IMP once every three days plus daily endometrin). I think the author of this article is a little confused about math. It should have said 20%. We also do not know if there were other confounding factors that lead to the results. I did not find the actual study publication, because the study is ongoing, so once it is completed, SG might come out with a different outcome and recommendations. Regardless, I would not take a chance, and just stick with whatever they recommend, PIO is true and tested and every 3 days of PIO is not that bad.

[Anonymous]

Beta test tomorrow after first fresh transfer. I hadn't asked only because I have a million other questions every time I meet w/ clinical team at SG, but if it is negative, what is the typical timeline for FET? Wait for period, BC, shots?

Thank you!

[Anonymous]

Anonymous wrote:Beta test tomorrow after first fresh transfer. I hadn't asked only because I have a million other questions every time I meet w/ clinical team at SG, but if it is negative, what is the typical timeline for FET? Wait for period, BC, shots?

Thank you!

Wait for period. 3 weeks of BC. Then, for me, it was nearly 2 weeks of estrace, a lining check, add progesterone (crinone) for 5 days, then transfer (injectionless protocol). I've done two FETs with the same protocol. First was a BFP and successful pregnancy. Second was a BFP later determined to be ectopic.

[Anonymous]

Anonymous wrote:In contrast, the live birth rate for frozen embryo transfers supported only by vaginal endometrin administration was 40 percent lower than that of cycles including IMP (28.6 percent live birth for endometrin only versus 47.3 percent live birth for daily IMP or IMP once every three days plus daily endometrin). I think the author of this article is a little confused about math. It should have said 20%. We also do not know if there were other confounding factors that lead to the results. I did not find the actual study publication, because the study is ongoing, so once it is completed, SG might come out with a different outcome and recommendations. Regardless, I would not take a chance, and just stick with whatever they recommend, PIO is true and tested and every 3 days of PIO is not that bad.

Um, no. Not bad math, 47.3% vs. 28.6% is an 18.7 percentage point difference, which is 40% of 47.3 percentage points. Pretty sure they double checked that. So you are 40% less likely to have a live birth in COMPARISON. Your overall live birth rate is 20% less.

[Anonymous]

If yo do medicated FET, do you need to keep getting the PIO shots even after you get a BFP? If you do a natural FET, I’m guessing you don’t need any additional shots after BFP?

[Anonymous]

PIO shots really aren’t that bad. It looks much worse than it actually is. If you can handle a pin prick on your finger, you can handle PIO shot. (And often, you don’t feel anything)
I will take (and did take) a tiny pin prick to increase my chance of success almost 20%.

[Anonymous]

Just went through medicated FET at SG. I was given PIO shots once every three days with suppositories the other two days. I elected to just do the PIO shots every day so that I didn't have to deal with the mess of suppositories. The PIO shots are not terrible despite the size of the needle. I was so anxious, but honestly it was not terrible. you will need to take them through week 10.

[Anonymous]

Natural FETs are usually supported by progesterone, too. You just do the transfer without hormonal cycle prep to set the transfer date. The timing isn't as predictable for Natural cycle FET as it's timed based on LH surge, which you track yourself with OPK or you go in and get blood tests to detect your LH surge timing. More room for error.

PIO is best for FET and in any case you take progesterone through 10 weeks.

For reference, CCRM and other REs that have very high rates of success use PIO every day and suppositories. And they don't recommend natural cycle FETs.