Help me with my appointment with Dr. Davis at Cornell today

[Anonymous]

Anonymous wrote:I don't get the point of freezing 2 day....what's the advantage? Just because they are fertilized?

They are just as strong and have as good these rates as blasts. In cleavage stage (ie day 3) there’s a tendency for more fragmentation/loss upon thaw. So for someone like me who doesn’t easily make blasts, freezing at 2pn allows me the chance to do an FET and to freeze something for later. The main downside is you can’t determine anything regarding quality in the way you can with a blast.

[Anonymous]

Anonymous wrote:

Anonymous wrote:I don't get the point of freezing 2 day....what's the advantage? Just because they are fertilized?

They are just as strong and have as good thaw rates as blasts. In cleavage stage (ie day 3) there’s a tendency for more fragmentation/loss upon thaw. So for someone like me who doesn’t easily make blasts, freezing at 2pn allows me the chance to do an FET and to freeze something for later. The main downside is you can’t determine anything regarding quality in the way you can with a blast.

[Anonymous]

I am the same PP from 9:21 and above... here are some sources:

https://www.ncbi.nlm.nih.gov/pubmed/20101847

https://www.ncbi.nlm.nih.gov/pubmed/26255088

Obviously there will be more successful pregnancies using blasts - since by the time embryos make it to blast, the weaker ones have generally died off. But if you can't make it to blast, or simply want more embryos in the bank, I think freezing at 2pn is a very solid choice (also because I do think - and Dr. Davis supports this - that perfectly healthy embryos die off on the way to blast when in vitro).