FET Protocol

[Anonymous]

When I did IVF with Columbia I had vaginal suppositories. My new clinic has me on daily intramuscular injected progesterone Ill report back if there is a difference.

[Anonymous]

Anonymous wrote:When I did IVF with Columbia I had vaginal suppositories. My new clinic has me on daily intramuscular injected progesterone Ill report back if there is a difference.

If there is a difference in pregnancy success outcome you won't know whether it's due to PIO. Even if you do nothing else different and had PGS tested embryos, those can still fail. Also, progesterone from suppositories isn't measured in the blood. Regardless, I hope you find success this time!

[Anonymous]

Thanks for good wishes. Of course I wont know its the exact reason. At Columbia we put back PGS normal embryo but it didnt take. I know its only 2/3 chance and those are the breaks.

That said I am please to know these results. I am a bit scared to do the daily intramuscular shots. Throughout this process I have paid to have a nurse administer the HCG shots but that is cost prohibited with daily shots. Now that I know these results ill be motivated plow ahead and administer myself. I have a dr friend lined up to help/teach me the first few days.

[Anonymous]

Anonymous wrote:

Anonymous wrote:When I did IVF with Columbia I had vaginal suppositories. My new clinic has me on daily intramuscular injected progesterone Ill report back if there is a difference.

If there is a difference in pregnancy success outcome you won't know whether it's due to PIO. Even if you do nothing else different and had PGS tested embryos, those can still fail. Also, progesterone from suppositories isn't measured in the blood. Regardless, I hope you find success this time!

For my fresh cycle, I used endometrin a vaginal suppository. For my FET, my RE said PIO has a slightly higher percentage rate of success than suppositories. If I were to insist on suppositories, he would have been fine with it, but of course I continue using PIO as I want to maximize my chances of success.

[Anonymous]

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:When I did IVF with Columbia I had vaginal suppositories. My new clinic has me on daily intramuscular injected progesterone Ill report back if there is a difference.

If there is a difference in pregnancy success outcome you won't know whether it's due to PIO. Even if you do nothing else different and had PGS tested embryos, those can still fail. Also, progesterone from suppositories isn't measured in the blood. Regardless, I hope you find success this time!

For my fresh cycle, I used endometrin a vaginal suppository. For my FET, my RE said PIO has a slightly higher percentage rate of success than suppositories. If I were to insist on suppositories, he would have been fine with it, but of course I continue using PIO as I want to maximize my chances of success.

I got similar advice but was the told PIO was about 25% higher.

[Anonymous]

Anonymous wrote:I know that the rationale behind PIO over Crinone or other vaginal progesterone is that PIO is the only way that it can be measured in the bloodwork. But what about the injectable estrogen? It seems like when I've been on oral Estrace for estrogen priming, they say they can measure it in my blood.

I'm wondering about this. Why does SG use Delestrogen shots?

[Anonymous]

I'm with GW. I had my first FET with GW in 2015 and I was on BC for a while, 3 weeks I believe. This FET, no BC.

20 units of Lupron for 10 days
Monitoring next business day
Decrease Lupron to 5 units and begin 1 patch every other day
Monitoring in 1 wk from start of patches
Start progesterone inserts
Transfer 5 days following

[Anonymous]

Anonymous wrote:I'm with GW. I had my first FET with GW in 2015 and I was on BC for a while, 3 weeks I believe. This FET, no BC.

20 units of Lupron for 10 days
Monitoring next business day
Decrease Lupron to 5 units and begin 1 patch every other day
Monitoring in 1 wk from start of patches
Start progesterone inserts
Transfer 5 days following

I am on this exact protocol now. Was your transfer 5 days after the second monitoring appointment? I am doing local monitoring so trying to figure out my travel schedule! My second monitoring appointment is Thursday.

[Anonymous]

Anonymous wrote:

Anonymous wrote:I'm with GW. I had my first FET with GW in 2015 and I was on BC for a while, 3 weeks I believe. This FET, no BC.

20 units of Lupron for 10 days
Monitoring next business day
Decrease Lupron to 5 units and begin 1 patch every other day
Monitoring in 1 wk from start of patches
Start progesterone inserts
Transfer 5 days following

I am on this exact protocol now. Was your transfer 5 days after the second monitoring appointment? I am doing local monitoring so trying to figure out my travel schedule! My second monitoring appointment is Thursday.

Yes, for a 5day blast it was.

[Anonymous]

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:I'm with GW. I had my first FET with GW in 2015 and I was on BC for a while, 3 weeks I believe. This FET, no BC.

20 units of Lupron for 10 days
Monitoring next business day
Decrease Lupron to 5 units and begin 1 patch every other day
Monitoring in 1 wk from start of patches
Start progesterone inserts
Transfer 5 days following

I am on this exact protocol now. Was your transfer 5 days after the second monitoring appointment? I am doing local monitoring so trying to figure out my travel schedule! My second monitoring appointment is Thursday.

Yes, for a 5day blast it was.

Oh wow - ok! Well I guess my transfer may be earlier than I had been anticipating!

[Anonymous]

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:I'm with GW. I had my first FET with GW in 2015 and I was on BC for a while, 3 weeks I believe. This FET, no BC.

20 units of Lupron for 10 days
Monitoring next business day
Decrease Lupron to 5 units and begin 1 patch every other day
Monitoring in 1 wk from start of patches
Start progesterone inserts
Transfer 5 days following

I am on this exact protocol now. Was your transfer 5 days after the second monitoring appointment? I am doing local monitoring so trying to figure out my travel schedule! My second monitoring appointment is Thursday.

Yes, for a 5day blast it was.

Oh wow - ok! Well I guess my transfer may be earlier than I had been anticipating!

As a heads up, I think it's less about number of calendar days passed and more about uterine lining and hormone levels.

[Anonymous]

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:I'm with GW. I had my first FET with GW in 2015 and I was on BC for a while, 3 weeks I believe. This FET, no BC.

20 units of Lupron for 10 days
Monitoring next business day
Decrease Lupron to 5 units and begin 1 patch every other day
Monitoring in 1 wk from start of patches
Start progesterone inserts
Transfer 5 days following

I am on this exact protocol now. Was your transfer 5 days after the second monitoring appointment? I am doing local monitoring so trying to figure out my travel schedule! My second monitoring appointment is Thursday.

Yes, for a 5day blast it was.

Oh wow - ok! Well I guess my transfer may be earlier than I had been anticipating!

As a heads up, I think it's less about number of calendar days passed and more about uterine lining and hormone levels.

Yes - with my first FET (also in 2015) I did get pushed 10 days because of thin lining, so I am fully anticipating not having a transfer next week.

[Anonymous]

Anonymous wrote:I am at GW. I can't recall my exact protocol for my first FET in 2015 that resulted in DD. I know on that cycle I did use birth control pills for a few weeks but this cycle I have not. I am currently in an FET cycle that looks like this:

-Cycle day 10, start monitoring for ovulation using OPK's
-4 days after ovulation occurs, start 20 units of Lupron injections (what I am doing now)
-9 days after starting Lupron - bloodwork and sono
-If all looks good, start estrogen patches and stay on lupron
-10 days later, blood work and sono
-If all looks good, stay on estrogen and start progesterone inserts
-Week later --> transfer

It's basically this calendar, although there appear to be fewer monitoring/blood work appointments in my cycle than indicated on the calendar:

http://www.advancedfertility.com/frozen-embryo-transfer.htm

Anonymous wrote:NP and I am GW. No BC, No Lupron for me.
1. Go in for baseline blood work on sono on Day2 of my menstrual cycle.
2. Start oral estrace on Day3, 3 times/day.
3. Go in for another blood work about 14 days after start of estrace to check for the desired hormone level & lining.
4. Start vaginal progesterone as instructed
5. Go in for the transfer either 2/3/4/5 days (depends on the stage of your embryo) after your progesterone start date.
6. Beta check after 2 weeks?

Anonymous wrote:I'm with GW. I had my first FET with GW in 2015 and I was on BC for a while, 3 weeks I believe. This FET, no BC.

20 units of Lupron for 10 days
Monitoring next business day
Decrease Lupron to 5 units and begin 1 patch every other day
Monitoring in 1 wk from start of patches
Start progesterone inserts
Transfer 5 days following

Anyone care to update w/ results?

[Anonymous]

Anonymous wrote:

Anonymous wrote:I am at GW. I can't recall my exact protocol for my first FET in 2015 that resulted in DD. I know on that cycle I did use birth control pills for a few weeks but this cycle I have not. I am currently in an FET cycle that looks like this:

-Cycle day 10, start monitoring for ovulation using OPK's
-4 days after ovulation occurs, start 20 units of Lupron injections (what I am doing now)
-9 days after starting Lupron - bloodwork and sono
-If all looks good, start estrogen patches and stay on lupron
-10 days later, blood work and sono
-If all looks good, stay on estrogen and start progesterone inserts
-Week later --> transfer

It's basically this calendar, although there appear to be fewer monitoring/blood work appointments in my cycle than indicated on the calendar:

http://www.advancedfertility.com/frozen-embryo-transfer.htm

Anonymous wrote:NP and I am GW. No BC, No Lupron for me.
1. Go in for baseline blood work on sono on Day2 of my menstrual cycle.
2. Start oral estrace on Day3, 3 times/day.
3. Go in for another blood work about 14 days after start of estrace to check for the desired hormone level & lining.
4. Start vaginal progesterone as instructed
5. Go in for the transfer either 2/3/4/5 days (depends on the stage of your embryo) after your progesterone start date.
6. Beta check after 2 weeks?

Anonymous wrote:I'm with GW. I had my first FET with GW in 2015 and I was on BC for a while, 3 weeks I believe. This FET, no BC.

20 units of Lupron for 10 days
Monitoring next business day
Decrease Lupron to 5 units and begin 1 patch every other day
Monitoring in 1 wk from start of patches
Start progesterone inserts
Transfer 5 days following

Anyone care to update w/ results?

I am the first poster above. Had a transfer in early October at GW and currently pregnant. First sono is later this afternoon. Fingers crossed!

[Anonymous]

My understanding is that PIO gets a higher pregnancy rate but suppositories have, ultimately, similar live birth rates (or at least the gap narrows). Curious phenomenon! I'd like to see the numbers.