For someone who is significantly overweight, I would get a doctor's sign-off and then start using the arc trainers at the gym, and the bikes. Both are efficient calorie burners, and have less impact on the joints than running. (and possibly walking.) Start at a low incline and resistance level and gradually up it. Then once you've lost some weight and your lungs are used to the exertion, get on the treadmill or sidewalk/road/trail/track and start walking, and then move on to a walk/jog combo. Gradually increase the Jog:walk ratio until you're mostly running. And don't give up! It will seem hard at first, but just keep pushing a little more at a time. (also hydrate, eat to fuel your activity and get fitted for good shoes.)
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