Weight Regain After Stopping Zepbound

[Anonymous]

Is it true that you regain most or all of the weight after stopping Zepbound — or even end up gaining more than you lost? For anyone who has stopped Zepbound, can you share what your experience was like once you came off the medication?

[Anonymous]

Not Zepbound but I took another rGLP1 and yes, you will regain the weight when you stop. If you were unable to control your hunger and cravings before taking the medication you will also struggle after. Everyone thinks losing weight is the hard part, but maintaining weight loss is more difficult.

Now are there some people who are successful in maintaining, sure, but they are the exception, not the norm and research backs this up. I think the ones who maintain are people who never really struggled with their weight, but rather gained a few extra pounds due to things like pregnancy or an injury so had ok eating habits to begin with.

[Anonymous]

Internist who prescribed for me said the same. If you are someone who is a healthy eater and has maintained a healthy weight for a long time but then gained 15-25 pounds because of menopause or illness/injury, you have a higher success rate for keeping the weight off if using Zep/GLP for short term weight loss.

If you are someone who has always struggled with weight does not have healthy eating habits and/or has genetic predisposition toward obesity, this is a lifelong drug. It suppresses your appetite while you are on it but unless you radically change your eating habits and relationship with food, you will go right back to where you were before. The threads about people delaying their dose because they wanted to gorge at Thanksgiving were a telling indication of this mindset that leads to people regaining weight.

[Anonymous]

Anonymous wrote:Internist who prescribed for me said the same. If you are someone who is a healthy eater and has maintained a healthy weight for a long time but then gained 15-25 pounds because of menopause or illness/injury, you have a higher success rate for keeping the weight off if using Zep/GLP for short term weight loss.

If you are someone who has always struggled with weight does not have healthy eating habits and/or has genetic predisposition toward obesity, this is a lifelong drug. It suppresses your appetite while you are on it but unless you radically change your eating habits and relationship with food, you will go right back to where you were before. The threads about people delaying their dose because they wanted to gorge at Thanksgiving were a telling indication of this mindset that leads to people regaining weight.

[Anonymous]

Anonymous wrote:Not Zepbound but I took another rGLP1 and yes, you will regain the weight when you stop. If you were unable to control your hunger and cravings before taking the medication you will also struggle after. Everyone thinks losing weight is the hard part, but maintaining weight loss is more difficult.

Now are there some people who are successful in maintaining, sure, but they are the exception, not the norm and research backs this up. I think the ones who maintain are people who never really struggled with their weight, but rather gained a few extra pounds due to things like pregnancy or an injury so had ok eating habits to begin with.

This really is key. People with actual health conditions that steered them to GLP-1’s like insulin resistance, PCOS, pre diabetic issues, etc. have a much harder time coming off of the meds than the many people who jumped on for vanity purposes.

[Anonymous]

Yes, you must change your eating habits and be in a calorie deficit forever. The only weight loss regiment is gastric bypass that is long term.

[Anonymous]

If all you did was take a shot and sit on the couch, then yes the weight is going to come back. If you used to shot as a tool and made lifestyle changes while you were on it, you may be ok

[Anonymous]

any harm if taking the meds to drop 20lb in 3 mo and then gain it all back next 10 years and then get back on it again to lose 20 once more? sounds like a good tradeoff to enjoy life more freely for 10 years then pause and regroup for 3 months and then enjoy another 10 years of happy live?

[Anonymous]

Anonymous wrote:If all you did was take a shot and sit on the couch, then yes the weight is going to come back. If you used to shot as a tool and made lifestyle changes while you were on it, you may be ok

If the “lifestyle changes” are eating less — which is what most women in their 40s and 50s need to do to lose weight — that becomes a lot harder to do when you’re hungry again.

I am a person who does a ton of strength training and eats healthy food already. But I’m eating too much of it to lose weight. If a GLP1 makes me less hungry, I will eat less and lose weight. But if I go off and the hunger comes back, I likely won’t be able to maintain.

[Anonymous]

I would say to not go on and plan to get off. I had done that with semaglutide and regained. It's hard because I am a normally healthy eater, don't drink, exercise...So basically just need to eat less to lose, and maintain as an older woman. I'm on tirzepatide now and my plan is to always be on it but low dose.

[Anonymous]

Anonymous wrote:any harm if taking the meds to drop 20lb in 3 mo and then gain it all back next 10 years and then get back on it again to lose 20 once more? sounds like a good tradeoff to enjoy life more freely for 10 years then pause and regroup for 3 months and then enjoy another 10 years of happy live?

It’ll come back in a year.

[Anonymous]

Anonymous wrote:

Anonymous wrote:any harm if taking the meds to drop 20lb in 3 mo and then gain it all back next 10 years and then get back on it again to lose 20 once more? sounds like a good tradeoff to enjoy life more freely for 10 years then pause and regroup for 3 months and then enjoy another 10 years of happy live?

It’ll come back in a year.

doubt it - took me 10 years to gain 20

[Anonymous]

Instead of asking the mommies here who have no idea what they are talking about, take a look at the Reddit GLPgrad sub to hear real stories. A lot of people who learn good habits and maintain them can, in fact, maintain their weight loss. Even people who lost 100+ pounds. But the key is learning and maintaining good habits. The DCUMommies are using GLP-1 as an appetite suppressant and still eating the same foods and drinking the same drinks and they will gain those pounds right back.

[Anonymous]

Calories in, calories out. GLP1s help control your appetite.

If you don't change your habits, you will regain the weight.

Change your habits and work on your discipline, and you can keep the weight off.

[Anonymous]

Anonymous wrote:

Anonymous wrote:If all you did was take a shot and sit on the couch, then yes the weight is going to come back. If you used to shot as a tool and made lifestyle changes while you were on it, you may be ok

If the “lifestyle changes” are eating less — which is what most women in their 40s and 50s need to do to lose weight — that becomes a lot harder to do when you’re hungry again.

I am a person who does a ton of strength training and eats healthy food already. But I’m eating too much of it to lose weight. If a GLP1 makes me less hungry, I will eat less and lose weight. But if I go off and the hunger comes back, I likely won’t be able to maintain.

This has been exactly my experience - I strength train and eat healthily, but start to gain weight from quantity. I have been able to stretch the doses though to maintain my weight loss. I start to get ravenously hungry around week 3-4 after an injection, and that’s around when I take it again for a single dose. If I have to inject myself once a month for the rest of my life I’m ok with that. The benefits to my health are worth it.