So smiley!

[Anonymous]

Just sharing a win!
Ds (level1) has been on leucovorin for about 3 months now.
We've noticed so many small improvements in engagement, mood, conversation but the best one has to be the smiles!
Today he came to show us something and had completely normall eye contact and the biggest, most beautiful smile the whole time! My heart is FULL!!!

[Anonymous]

Can you share which practice prescribed this for him?

[Anonymous]

Congrats, OP!

[Anonymous]

Why is he on it?

[Anonymous]

Anonymous wrote:Why is he on it?

They have found that 75% of autistic people have an underlying immune condition where their bodies mistakenly create antibodies thatbattack the folate receptors. This results in a folaye deficiency in the brain. * The brain needs folate to function properly.
Since a huge majority of autistic people have this underlying condition, every autistic person should be tested for this.

* please note that a regular serum folate tesr does NOT show folate deficiency because this is not caused by lack of ingesting enough folate. The problem occurs when the body tries to transport that folate across the blood- brain barrier. Those specific folate receptors are comprised and can't do their job. So blood test is fine but if you did a spinal tap you would find low levels of folate in the spinal fluid. Obviously they dont want to do such an invasive procedure, so Dr Quadros devised a test to look for and measure the auto antibodies. If the antibodies exist you can reasonably assume there is a lack of folate in the nervous system/brain

[Anonymous]

Anonymous wrote:Can you share which practice prescribed this for him?

Neurologists should be familiar with this because Cerebral Folate Deficiency is a neurological condition.
Alot of parents are sending the research to their pediatricians who are learning about it and ordering the tests. It is very straightforward for them to understand how to treat this. The dosing is 1-2 mg per kg of body weight and its brought up slowly.
The pediatricians need to do as much and more effort than we are into understanding how to help what turns out to be a very common autoimmune condition ans subsequent anemia in some children so I recommend you start with your pediatrician and push them to understand it. They should be recommending the test for all of their autistic patients.

[Anonymous]

Sounds like an advertisement.

[Anonymous]

Anonymous wrote:Sounds like an advertisement.

Probably Russian bots trying to mind control you. You can actually go straight to the internet and help yourself to the information. My experience has been that people are so exhausted by the years of "its gluten! Its mom's age! Its the jab!" That they're worn down and hesitating not following up in something very important. There is alot of good i didn't say about it because it does sound incredulous and people's response has been almost comically cold to an actual, scientific breakthrough. But its also not a cure for autism z and if won't help everyone, unfortunately.

[Anonymous]

Anonymous wrote:Sounds like an advertisement.

Advertisements use spell check

[Anonymous]

Anonymous wrote:

Anonymous wrote:Sounds like an advertisement.

Probably Russian bots trying to mind control you. You can actually go straight to the internet and help yourself to the information. My experience has been that people are so exhausted by the years of "its gluten! Its mom's age! Its the jab!" That they're worn down and hesitating not following up in something very important. There is alot of good i didn't say about it because it does sound incredulous and people's response has been almost comically cold to an actual, scientific breakthrough. But its also not a cure for autism z and if won't help everyone, unfortunately.

We don't call it the jab here. Are you a foreign bot?

You write like spam even though you don't mean to.

[Anonymous]

Anonymous wrote:

Anonymous wrote:Why is he on it?

They have found that 75% of autistic people have an underlying immune condition where their bodies mistakenly create antibodies thatbattack the folate receptors. This results in a folaye deficiency in the brain. * The brain needs folate to function properly.
Since a huge majority of autistic people have this underlying condition, every autistic person should be tested for this.

* please note that a regular serum folate tesr does NOT show folate deficiency because this is not caused by lack of ingesting enough folate. The problem occurs when the body tries to transport that folate across the blood- brain barrier. Those specific folate receptors are comprised and can't do their job. So blood test is fine but if you did a spinal tap you would find low levels of folate in the spinal fluid. Obviously they dont want to do such an invasive procedure, so Dr Quadros devised a test to look for and measure the auto antibodies. If the antibodies exist you can reasonably assume there is a lack of folate in the nervous system/brain

Please share a citation and explain who "they" are.

[Anonymous]

You write like a spammer and you aren't providing the information people actually need. That's why people ignore you. It's not because they're burned out (though they are). It's because you aren't persuasive. You sound like you're trying to sell essential oils.

For anyone who would actually like to read real studies:

https://pmc.ncbi.nlm.nih.gov/articles/PMC7477301/

https://www.nejm.org/doi/full/10.1056/NEJMoa043160

https://pmc.ncbi.nlm.nih.gov/articles/PMC3578948/

[Anonymous]

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:Why is he on it?

They have found that 75% of autistic people have an underlying immune condition where their bodies mistakenly create antibodies thatbattack the folate receptors. This results in a folaye deficiency in the brain. * The brain needs folate to function properly.
Since a huge majority of autistic people have this underlying condition, every autistic person should be tested for this.

* please note that a regular serum folate tesr does NOT show folate deficiency because this is not caused by lack of ingesting enough folate. The problem occurs when the body tries to transport that folate across the blood- brain barrier. Those specific folate receptors are comprised and can't do their job. So blood test is fine but if you did a spinal tap you would find low levels of folate in the spinal fluid. Obviously they dont want to do such an invasive procedure, so Dr Quadros devised a test to look for and measure the auto antibodies. If the antibodies exist you can reasonably assume there is a lack of folate in the nervous system/brain

Please share a citation and explain who "they" are.

Why are people like you so awful? Its obvious "they" are the researchers that op wrote about. And there were numerous descriptions of where to find more information if you would like citations.

[Anonymous]

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:Why is he on it?

They have found that 75% of autistic people have an underlying immune condition where their bodies mistakenly create antibodies thatbattack the folate receptors. This results in a folaye deficiency in the brain. * The brain needs folate to function properly.
Since a huge majority of autistic people have this underlying condition, every autistic person should be tested for this.

* please note that a regular serum folate tesr does NOT show folate deficiency because this is not caused by lack of ingesting enough folate. The problem occurs when the body tries to transport that folate across the blood- brain barrier. Those specific folate receptors are comprised and can't do their job. So blood test is fine but if you did a spinal tap you would find low levels of folate in the spinal fluid. Obviously they dont want to do such an invasive procedure, so Dr Quadros devised a test to look for and measure the auto antibodies. If the antibodies exist you can reasonably assume there is a lack of folate in the nervous system/brain

Please share a citation and explain who "they" are.

Why are people like you so awful? Its obvious "they" are the researchers that op wrote about. And there were numerous descriptions of where to find more information if you would like citations.

Oh where were these numerous descriptions? OP name-checked one researcher, that's it, so I found some stuff by googling.

OP complained that people don't follow up. But they don't follow up because OP isn't providing the information and OP's tone is spammy, like she's trying to draw attention before making a sales pitch.

[Anonymous]

Anonymous wrote:You write like a spammer and you aren't providing the information people actually need. That's why people ignore you. It's not because they're burned out (though they are). It's because you aren't persuasive. You sound like you're trying to sell essential oils.

For anyone who would actually like to read real studies:

https://pmc.ncbi.nlm.nih.gov/articles/PMC7477301/

https://www.nejm.org/doi/full/10.1056/NEJMoa043160

https://pmc.ncbi.nlm.nih.gov/articles/PMC3578948/

Pound sand. Pp. It was a parent sharing a success which is much more readable than a bunch of link drops that have zero relationship with actual autism parenting. But thanks a sh!t ton for "Cerebral folate deficiency (CFD) syndrome is a recently described neurometabolic disorder characterized by low concentrations of 5-methyltetrahydrofolate (5MTHF) in the cerebrospinal fluid (CSF), despite normal systemic folate levels. CFD is believed to be caused by the impaired transport of folates across the blood–brain barrier. The first reported cases of CFD manifested severe neurodevelopmental symptoms including spastic paraplegia, cerebellar ataxia, dyskinesia, seizures, acquired microcephaly and developmental regression, which occurred as early as 4 months of age.1, 2 Central visual disturbances (optic atrophy and blindness) and hearing loss occurred after age 3 and 6 years, respectively, in some cases.2"


Et, al! Lmao