High dose Adderall (30mg or more) associated with psychosis

Anonymous
New study

https://psychiatryonline.org/doi/10.1176/appi.ajp.20230329

"A dose-response relationship was observed; high doses of amphetamines (>30 mg dextroamphetamine equivalents) were associated with 5.28-fold increased odds of psychosis or mania."
Anonymous
Not surprising to me at all based on our experience. But I remain grateful this medicine works wonders for others.
Anonymous
I know that several doctors have said that the Genesight testing is not helpful/evidence based at this point. But could the Genesight testing screen for this potential side-effect (psychosis) at all?
Anonymous
Ugh. Has anyone read the whole study? I’m wondering if this is an issue for kids that have been on the medicine long term without issues or more of an issue for kids that have adverse side effects with it?
Anonymous
There is no free lunch.
Anonymous
That seems like a really high dose? My kid takes a different med, but the dose is much lower.
Anonymous
Anonymous wrote:That seems like a really high dose? My kid takes a different med, but the dose is much lower.


I don't think so. It's been years since DS was on this med, but i think starting dose is 10mg for kids in K.
Anonymous
People with psychosis or mania need a higher dose. How is this surprising?
Anonymous
Its interesting they found methylphenidate didn't have the same association.
Anonymous
Anonymous wrote:That seems like a really high dose? My kid takes a different med, but the dose is much lower.


Its on the high end; 5mg is typically the starting titration in children, 20mg is the "typical" adult dose. 40mg is the FDA's suggested maximum. Its dosed at up to 60mg for severe ADHD and narcolepsy.
Anonymous
Anonymous wrote:People with psychosis or mania need a higher dose. How is this surprising?


This.
Anonymous
Anonymous wrote:People with psychosis or mania need a higher dose. How is this surprising?


huh? adderall is not a treatment for psychosis.
Anonymous
Anonymous wrote:People with psychosis or mania need a higher dose. How is this surprising?


But they only saw this impact on the hospital patients taking adderall, not concerta.
Anonymous
Anonymous wrote:New study

https://psychiatryonline.org/doi/10.1176/appi.ajp.20230329

"A dose-response relationship was observed; high doses of amphetamines (>30 mg dextroamphetamine equivalents) were associated with 5.28-fold increased odds of psychosis or mania."


I mean … duh?

—someone who has, unfortunately, struggled with a condition that causes mania

Anonymous
Anonymous wrote:I know that several doctors have said that the Genesight testing is not helpful/evidence based at this point. But could the Genesight testing screen for this potential side-effect (psychosis) at all?


No
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