It may not happen as much/at all when your friend is home, but it probably happens at least somewhat. Cats do this to express their feelings, and most cats have big feelings about changes in their environment. Withdrawing food will only agitate them more, and could cause actual GI problems (not just attitude problems).
Are they leaving their offerings/protests in a regular location? That can sometimes be a clue as to what they're upset about. It's probably not a medical issue. If the cats are eating, and the litterbox is filling, I'd blame 'tude. They're used to having someone home more often, and you're only there (to serve them) for a couple brief visits. Their Majesties are demanding attention. It sounds weird, but on the first visit when she's away, try playing with them (laser, catnip, the good stuff) and talking to them about how she's gone and you'll be around.
As long as they're staying hydrated and still have an appetite, I wouldn't worry much about it.
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