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preimplantation genetic diagnosis
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Anonymous
| Anyone use it? Why? How did it work? Have had 4 miscarriages so am considering it (not for a designer baby or a particular gender). Any *positive* info appreciated. Any judgemental posters should not cast the first stone or at least should walk a mile in my shoes first. |
Anonymous
|
I usually refer people to IVFconnections, but unfortunately no new members can join. My understanding is that pgd works well if you do the more advanced (newer) processes (one is called microarray - I can't remember the other right now) that looks at all the chromosomes. The older processes that only look at certain chromosomes don't seem to diminish the chance of miscarriage unless the couple has a particular genetic issue that it can spot.
There might be some discussion on SIRM's haveababy.com boards - they offer the advanced testing. Good luck - I'm sorry for your losses. |
Anonymous
|
Sorry for your losses. I also had several miscarriages interspersed w/3 healthy kids (#2&3 were twins).
Do you know why you're miscarrying? Have you had tissue tested to confirm chromosomal issues and not a clotting or other problem? In my case, each loss was due to chrom probs, but different ones each time. My approach was to use acupuncture, start working out and basically get as healthy as possible to give my body the best chance at properly dividing its old eggs. We were planning to do PGD, but got lucky w/an IUI (which was required by insurance before they'd pay for IVF) that yielded twins. Sending you hope ... |
Anonymous
| Do you know if the m/c's were caused by chronosomal problems? Another clinic that is very advanced with chromosomal testing of embryos is CCRM in Colorado, but they are very expensive. |
Anonymous
| OP here. I do know that #1 and #2 were due to chromosonal problems, Am waiting to hear about #3 and #4. Last two were conceived w/ IUIs. |
Anonymous
| OP again. Chromo problems were different each time. We had genetic testing done and nothing showed up. |
Anonymous
| Poster 12:16 - I am not the OP, but do want to know what dietary changes you made and how much/what exercise you were doing before you got pregnant. i was told to cut back on workouts when i started ttc and have gained weight. and, i just had a m/c 6 weeks and do want to do what i can to be healthier before cycling again. |
Anonymous
| OP here - According to some, dietary changes need to begin 3 months before conception, as your egg is "called up" in line at that point. You may want to check and see if you ahve any unknown allergies or food sensitivities. I found out a month into my pregnancy that I had a strong sensitivity to eggs, and I had been eating 2 hard boiled eggs for breakfast every morning. Thomas Jefferson hospital in Philly did a study that showed that women w/ food allergies/senesitivites are 4 times more likely to have miscarriages, though they don't know why yet. Wish I had known before, and maybe my last pregnancy would have succeeded. On exercise - was told to do only low impact stuff. Overheating is a problem w/ TTC. |
Anonymous
| Question - this is interesting. Where can I get the allergy testing done? |
Anonymous
|
I'm sorry for your losses. We went through IVF 9 times to conceive our kids and did PGD on most of those cycles b/c my DH has a chromosome abnormality which causes among other things a 50% chance of a Trisomy 13 or 14 baby. We went to Shady Grove Fertility and at the time we did it (several years ago) it was about 95% accurate so we also did a CVS. We looked at chromosomes 13, 14, 18, 21 and the sex chromosome although I believe SGF now has the ability to look at all of the chromosomes.
I have mixed feelings about PGD. My first child was conceived by using it. The good thing about it is I felt like we were getting information about what was going on with my embryos. I would have beautiful 8 cell embryos on Day 3 that weren't chromosomally normal but cruddy 5 cell embryos were. After doing so many cycles we at least started to get some answers about what was going on with our embryos, etc. For us - I think PGD was too hard on our embryos. They pulled the cell off for biopsy on Day 3 - and would transfer on Day 5. We would transfer beautiful 5 day normal blasts and still miscarry. Nothing worse than going through IVF and still miscarrying. So on our last cycle we decided to forgo PGD and just put back the remaining 3 embryos that we had on Day 3 and thankfully that resulted in our twins. I believe SGF now does PGD later in the cycle hoping the embryo is stronger so it won't be as traumatic to have the cell removed. So I think there are pro's and con's to PGD. It might provide answers as to what is going on - why you are miscarrying but it might not. Just don't go into it thinking that it will be the silver bullet to getting pregnant. I was a bit and naive and thought as long as we had some normal ones to transfer we'd be golden and I think I still miscarried on 3 of my IVF cycles if I remember correctly. Good luck! |
Anonymous
| That was really helpful - thank you for sharing. |
Anonymous
12:16 here. Just seeing this now. Didn't make drastic changes other than added some red meat/beef broth to a formerly vegetarian diet. This was a suggestion of the acupuncturist. Otherwise just tried to eat less crap and more fresh, whole foods. I have always tended to be a little heavy, so lost about 5 lbs. Started running, but again, nothing extreme. 3 miles or so a few times a week. Good luck to you. |
Anonymous
| CCRM can do testing on the genetic makeup of the egg without disturbing the actual embryo. I'm not sure of the details though. Might be worth a phone consult with them if you think you might consider going out to Colorado. |
Anonymous
| Genetics & IVF in Fairfax, VA can do PGD. I used to supervise a genetics lab and believe they have an excellent lab! |
Anonymous
| Anyone know about success rates for IVF using PGD for women over 40? (am 41) |