Does PGS detect translocations?

[julesalter]

Can you have a PGS normal embryo with undetected translocation issues ? I have had 5 blasts failed to implant. We have one last and the doctor suggests surrogacy. I am wondering if PGS testing will test for aneuploidy yet can miss chromosomal translocations that may cause failed implantations? Will doing karyotyping give some answers if it really is a uterine issue or something not right with the embryos?

[Anonymous]

julesalter wrote: Can you have a PGS normal embryo with undetected translocation issues ? I have had 5 blasts failed to implant. We have one last and the doctor suggests surrogacy. I am wondering if PGS testing will test for aneuploidy yet can miss chromosomal translocations that may cause failed implantations? Will doing karyotyping give some answers if it really is a uterine issue or something not right with the embryos?

When you did PGS testing they had to have had you discuss these issues with a genetic counselor. Can you get your nurse to get you in touch with those people again? PGS is not foolproof.

[Anonymous]

julesalter wrote: Can you have a PGS normal embryo with undetected translocation issues ? I have had 5 blasts failed to implant. We have one last and the doctor suggests surrogacy. I am wondering if PGS testing will test for aneuploidy yet can miss chromosomal translocations that may cause failed implantations? Will doing karyotyping give some answers if it really is a uterine issue or something not right with the embryos?

I am pretty sure they need a special probe for translocations and they are not typically caught by PGT-A. Have you and your partner been tested for them? I think that would be the first step.

[Anonymous]

I think PGT-M does.

[Anonymous]

Anonymous wrote:I think PGT-M does.

PGT-A can miss balanced translocations if I'm understanding correctly.