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Endometrial Biopsy - HELP!
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Anonymous
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After two failed NCIVFs and one failed stimulated IVF, I'm getting a bit concerned that I have a lining issue. All 4 embyos that have ever been put back have all been blasts and look good according to the embryologists. None have implanted. I'm 33 and healthy and so far, MF is our only "issue." We're using donor sperm and doing shared risk at SG.
I've been begging my RE at SG to do an endometrial biopsy on me but he says that the results are not predicative of success so he won't perform one for me. Has anyone had an endometrial biopsy done and did it help you figure out anything that could have been wrong with you? Should I push my RE to perform one or ask my OB to do one instead? I just don't know if its worth the fight to get one. Thanks for your help! |
Anonymous
| Cornell does the biopsy as part of a co-culture process that creats a petri dish medium for the embryos. I assume that if there was anything useful to gain by analyzing the tissue they'd analyze it, but they don't. I've also heard about people getting the biopsies done to improve implantation rates (I believe a study from israel showed this -- maybe you could find it on google). I realize this doesn't help much - sorry... |
Anonymous
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SG won't do it.
i asked my RE at SG for a biopsy, hysteroscopy and any other tests that could help figure out if there is a problem with my uterus after failed implantation of "perfect looking" 3-day and 5-day embryos. she only said she would do an hsg and if there was any indication that something is wrong, then she would do the hystero. i forget what she said about the endo biopsy (i had so many questions for her). |
Anonymous
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OP, we have nearly identical histories, same age and same reason for pursuing IVF. I had the endometrial biopsy done as part of my diagnostic testing at CCRM, it revealed that I lack beta integrin protein which is necessary for embryo implantation. The test is usually not covered by insurance, cost me $475. Don't know why most clinics don't suggest it to patients with multiple IVF failures. My doc at CCRM said that the vast majority of his patients who were in the same situation as us, (under 35, male factor,multiple IVF failures) were found to lack this protein and when he tweaked their protocol, they all went on to get and stay pregnant. The company who created the test is called E-tegrity, maybe you can check their website to find docs around here who do the test.
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Anonymous
| Strange that your doctor will not do endometrial biopsy after failed IVFs. Dr. Sharara did this test on me althouth I already had a pregnancy (that turned out to be a blighted ovum and I had to go through D&C) and I was not even considering an IVF at that point. I think it was totally useless for me (it came back fine) because our main issue is male factor (poor motility and morphology). I am going for natural IVF in July. |
Anonymous
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interesting post: http://www.infertilitydoctor.com/tag/uterine/
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Anonymous
interesting indeed, but one would think that the high negative result rate could also be attributable to the fact that the women who opt for this biopsy are usually those that experience multiple implantation failures. So, its not your typical population that is undergoing this test. |
Anonymous
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OP here...thank you all so much for your responses. As always, super helpful!
Poster 14;28...after you did the E-tegrity test, what exactly did your RE do to your protocol to "tweak" it so that it helped remedy the issues with the lack of beta integrin protein? TIA! |
Anonymous
After retrieval, they freeze embryos at blast stage on day 5. Starting with the first period after retrieval you do a shot of depo lupron, then the next month you do another shot of depo lupron. In the third month you go into CCRM's regular protocol for FET. You can use that time in between retrieval and embryo transfer to send the embryos out for genetic testing. |
Anonymous
| Poster 13:52...just so I understand your explanation correctly, to basically combat your issue with the beta integrin protein, you took two shots of Lupron (one shot each month prior to beginning your FET protocol)? Thank you for your help! |
Anonymous
correct, but this is not regular lupron. it's pretty heavy duty stuff, you might get hot flashes, headaches, insomina, night sweats, and no period for 2months. there is a another drug some clinics prescibe for the beta integrin called letrozole, but my doc at ccrm advised against it b/c he hasn't seen as good results. also, i searched around and didn't find very many positives for women who did the letrozole instead of depo lupron. good luck! |
Anonymous
| Thank you so much for the clarification poster 11:15! |