Although you can't officially diagnose until 3, you can start to see behavior that may be of concern. In this case, however, the situation may seem worse than it is simply b/c his sister is ahead, which is not at all uncommon with boys/girls. So the boy may be delayed in certain things (e.g., eye contact, following your finger, etc.), but the girl may be ahead and that makes it seem worse. Do you attend the well child visits with the family? Are these the only kids?
When our youngest was born, we had some developmental concerns, and we raised them with our dr and he gave us a list of things to watch out for and to keep notes. I would mention this to your MB, not as a concern, but in a "I know that girls/boys develop at different stages, but I've noticed that boy does x, y, z. Have you noticed that?" Our nanny mentions stuff all the time. She's with our kids 8 hours a day during waking hours and she might be the first person to see something come up. Candidly, if my nanny didn't say something to me, I'd be annoyed.