I did mounjaro for 9 months and lost 50 lbs. it was great, but 10mg stopped working. I gained it all back over 2 years. I tried again and drug didn’t work the second time, no help at all. I thought I could keep up the good habits, but when hunger and food noise came back I went back to my old ways.

Seriously, it's a miracle and my only regret is not starting compounded sooner. IMO, all insurance companies should be covering these drugs if they want to cut long-term health costs. I feel and look better than I have in years.

Anonymous wrote:So I’ve been on compounded ozempic for 4 months and have lost 15 pounds. I spent a month at .25 mg, a month at .5 mg and have been on 1 mg since. I’ve steadily lost about a pound a week. The most interesting thing to me is that we were on vacation for the past two weeks and I ate pretty much what I wanted, though didn’t overeat because I do get full, and lost a pound on vacation.

I love this too!

Anonymous wrote:I did not read through this thread so forgive me if this has already been posted, but has anyone been on semaglutide for over a year without having their hunger/cravings return?
I was on semaglutide for a few months and it worked great and then my cravings came back. I was on various semaglutide groups and this seems like the standard outcome.
I hear so many people say when first starting that they plan on doing this long term, but from what I can tell that's impossible. It seems like it losses effectiveness after 1-2 years at best.

I'm almost at the 2 years mark. Occasionally I have "breakthrough" hunger - but it's short and rare.
I cannot believe the difference it's made in my everyday life.

So I’ve been on compounded ozempic for 4 months and have lost 15 pounds. I spent a month at .25 mg, a month at .5 mg and have been on 1 mg since. I’ve steadily lost about a pound a week. The most interesting thing to me is that we were on vacation for the past two weeks and I ate pretty much what I wanted, though didn’t overeat because I do get full, and lost a pound on vacation.

I did not read through this thread so forgive me if this has already been posted, but has anyone been on semaglutide for over a year without having their hunger/cravings return?
I was on semaglutide for a few months and it worked great and then my cravings came back. I was on various semaglutide groups and this seems like the standard outcome.
I hear so many people say when first starting that they plan on doing this long term, but from what I can tell that's impossible. It seems like it losses effectiveness after 1-2 years at best.

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Anonymous wrote:All these people at 140 weren’t even fat. SMH.

140 is overweight for me at 5’1. 130 is the upper limit of my bmi.

You were barely overweight. If you'd lost 8 pounds you'd have been in the normal range. You couldn't lose 8 pounds through your own efforts?

NP- I am roughly this poster and it's very hard losing weight as a short, middle aged woman. GLP-1s make it finally seem fair: exercise and good nutrition actually pay off in real ways combined with the medication. I was active and ate well before, and every pound took a month and tremendous mental effort. It was discouraging to the point of being depressing.

I was thin my whole life and have gained 30 pounds in the last 5 years even though I increased my walking and decreased my carbs. I lost about 10 pounds last year through 8 months of really intense dieting but then had a month where I had a lot of work meetings and had to eat more like a normal person and gained it all back in one month of not dieting. So I haven’t really tried again. I am wondering if a small dose would help me. I am 5’4” and up to 155 now. I’m already on HRT and that doesn’t seem to help.

Are we now deciding that gaining 30 lbs in menopause (wiht no health problems) is not normal? This has been normal since time began for majority of women.

Might be typical but it isn’t a good thing

I gained 30 lbs during peri and through menipause (a lot in bust size much to my chagrin). I eat healthy, exercise regularly, have good muscle mass, and my actual weight is not in the overweight category. My blood tests are all perfectly within normal range, I wear a size 8. What is the problem?

30 pounds of fat that you keep on after perimenopause is 30 pounds of estrogen production, which can raise your risk of breast and other cancers that feed on estrogen (which is a lot). In women, fat tissue produces estrogen, and this estrogen production continues through perimenopause and menopause.

It will be interesting to see if GLPs cause a decrease in hormone positive cancer over the longer term. There is evidence on this for some cancers -- https://pubmed.ncbi.nlm.nih.gov/40839273/

Anonymous wrote:It's like meth or other weight loss drugs. Just because you dropped some weight doesn't mean you are healthy yet.

That's only part of it. If you are pre-diabetic at that weight, then you have to change your diet and activity levels.

Thanks for the PSA

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Anonymous wrote:All these people at 140 weren’t even fat. SMH.

140 is overweight for me at 5’1. 130 is the upper limit of my bmi.

You were barely overweight. If you'd lost 8 pounds you'd have been in the normal range. You couldn't lose 8 pounds through your own efforts?

No, and why should I? You sound jealous.

Not fat, not jealous.

Not being fat is not an advantage anymore.
You do sound rather jealous/ annoyed.

This. All of it. +1

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Anonymous wrote:

Anonymous wrote:All these people at 140 weren’t even fat. SMH.

140 is overweight for me at 5’1. 130 is the upper limit of my bmi.

You were barely overweight. If you'd lost 8 pounds you'd have been in the normal range. You couldn't lose 8 pounds through your own efforts?

No, and why should I? You sound jealous.

Not fat, not jealous.

Not being fat is not an advantage anymore.
You do sound rather jealous/ annoyed.

Anonymous wrote:144 is slightly overweight, how do you qualify for the prescription?

You can always have a doctor prescribe it off-label and pay out of pocket (rather than using insurance). Cash prices are a lot better than they used to be. Starter doses of Zepbound are only $300.

144 is slightly overweight, how do you qualify for the prescription?

I'm about to start compounded semaglutide, and will be interested to see what it does. Over a 10-year period I lost 80 lbs, getting to my lowest just when COVID started (dammit!). I've gained 15 lbs back slowly, to where I am near the top of the overweight category in my late 50s. I've used low carb, low fat, low eating and they've all worked, and really quieted the food noise for a long time. (also helps to be living solo) I don't ever really dream of being THIN, but even just getting back to where I was pre-COVID (which was only about 5 lbs above what I weighed in high school and the highest end of the "normal" category) would be amazing.

I am hoping that perhaps I can be one who can get by on a low dose. I'm not diabetic, cholesterol actually dropped this past year (though is still above normal), and my blood pressure is well controlled with just a diuretic. But it's easy for me to get lazy both in terms of eating and in terms of exercise, and then it's harder to just clean up my act for a bit and see a drop in weight enough to motivate me to keep pushing.

I guess I shall see.

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Anonymous wrote:It's like meth or other weight loss drugs. Just because you dropped some weight doesn't mean you are healthy yet.

That's only part of it. If you are pre-diabetic at that weight, then you have to change your diet and activity levels.

gee, thanks. this is the first time I'm hearing this. /s

Well it bears repeating, even if you already knew, as some might not realize that being healthy is more than just what the scale says you have lost.

Oh FFS. Do you go around pointing out the obvious to everyone you know? I'm guessing people do not like you.

Is irrational anger a side effect of the drug?

Pp is right, Captain Obvious.

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Anonymous wrote:It allowed me to get rid of the menopause weight that would not budge no matter what I did. My doctor was sort of judging the weight gain, told me I wasn’t exercising enough, etc. so I didn’t feel everything she said for a year and came back 8 pounds heavier. She gave me her blessing to go on it but didn’t prescribe it herself since my labs were ok.

The other thing besides food noise is that it completely quieted the alcohol noise. In my case that might actually be the culprit and I was struggling to control it. Turned it off like a light switch, and that’s worth the price. I am not a slave to the glass of wine anymore. Went to a big party the other night and I opted for a mocktail and it was great. I’m staying it on it in a maintenance dose for this reason alone.

What is your maintenance dose?

10 units, or .5 mg, sg through Willow. It affected me a lot so I lost weight quickly and to be honest too fast so I never made it anywhere near their suggested full dose. 10 seems to be enough and may reduce further.