Anonymous
11/12/2025 20:34
Subject: FDA removed black box warning for HRT
Anonymous wrote:Anonymous wrote:HRT (estradiol patches and oral progesterone) has been transformative for me. I have yet to see evidence of it causing strokes. When you put that on the internet, you are spreading more misinformation and it's not helpful. I wish another, much more credible administration had made this decision but I also don't disagree with it.
Congrats to all those who have shared that they have gotten through perimenopause/menopause with few problems. Sounds lovely but your experience is pretty irrelevant to anyone else's experience. Also, there is no prize for avoiding night sweats/mood swings/frozen shoulder/joint pain (etc) and acting smug about it.
If you don’t know about the stroke risk your doctor didn’t educate you well.
https://www.ahajournals.org/doi/10.1161/STROKEAHA.121.038659
And estrogen PATCH is not ORAL estrogen, so the risk for stroke doesn't exist. It doesn't pass thru your liver the way oral estrogen does.
So please educate yourself before typing
Anonymous
11/12/2025 20:32
Subject: FDA removed black box warning for HRT
Anonymous wrote:Anonymous wrote:Anonymous wrote:Anonymous wrote:I don’t trust anything RFK jr or trump says. This FDA is currently SUS so I’m seeing this as a red flag. If they promote it, I should not consider it.
If it was legitimately safe, Melania should have made the announcement. Woman to women.
I’ll wait until we have actual medical experts back in the FDA before I trust their advice.
Wow - you would have given it more credence out of Melania’s mouth? That’s moronic.
HRT has enabled me to sleep through the night regularly for the first time in a year. Game changer.
And has increased your risk of stroke and cancer.
Not stroke, bc presumably she’s not taking oral estrogen. Maybe a tiny absolute increase in breast cancer risk, which depending on family history is likely outweighed by a decrease in risk of heart disease, diabetes, and all-cause mortality.
+1
It's all about risks for everything. If you have a few drinks a week, you likely have a higher risk of Breast cancer from that than using HRT. If you eat crap, you have a much higher risk of heart attack/stroke/other health issues than someone who exercises and eats healthy.
However, the HRT protects our heart and our bones and diabetes and other things that also matter.
Be informed, make your CHOICES. But for most (without a family history or their own history of Breast cancer/cancer) the risk is likely very minimal versus the overall benefits to your body and quality of life
Anonymous
11/12/2025 20:30
Subject: Re:FDA removed black box warning for HRT
Anonymous wrote:Anonymous wrote:Let’s get some education backed discussion going.
The original capital HRT was… conjugated equine estrogens (CEE), often sold under the brand name Premarin®.
For women who still had their uterus, a progestin was added to the estrogen to prevent endometrial cancer. The standard combination was CEE plus medroxyprogesterone acetate (MPA), the active ingredient in Provera®, which was often prescribed together as the combined pill Prempro.
It was a high dose, pill form, in women around 60.
Now being offered … 17β-estradiol, which has the same chemical structure as the primary estrogen produced by the human ovaries (making it "bioidentical"), rather than animal-derived or synthetic estrogens. This is available in various forms, including pills (e.g., Estrace, Gynodiol), patches (e.g., Vivelle-Dot, Minivelle), gels, and sprays.
What we really need is more money towards women research .. research that was cancelled last Spring.
Exactly! The key is the new HRT is bioidentical---better suited for most women.
And yes, we need more research. If men went thru menopause, we would have tens of excellent choices decades ago (just look at all the forms of viagra readily available)
Bioidentical has been around for years. There's actually nothing better about it. It's a marketing term only. You are not safer on this than any other hormone.
Anonymous
11/12/2025 20:30
Subject: FDA removed black box warning for HRT
Anonymous wrote:HRT (estradiol patches and oral progesterone) has been transformative for me. I have yet to see evidence of it causing strokes. When you put that on the internet, you are spreading more misinformation and it's not helpful. I wish another, much more credible administration had made this decision but I also don't disagree with it.
Congrats to all those who have shared that they have gotten through perimenopause/menopause with few problems. Sounds lovely but your experience is pretty irrelevant to anyone else's experience. Also, there is no prize for avoiding night sweats/mood swings/frozen shoulder/joint pain (etc) and acting smug about it.
Because they don't. It's oral estrogen that can cause strokes/blood clots (probably a similar risk as taking BC pills from your teens until you hit menopause like some people do). Most of us thought nothing of using BC pill and dealing with the risks (it's not pretty if it happens to you---I was 23 and my mentor had it happen, she was 29 and in the hospital for over a week and another 2 weeks+ to recover before returning to an office job). But you can use the oral progesterone and a patch estrogen and eliminate the stroke/blood clot risks
Anonymous
11/12/2025 20:29
Subject: FDA removed black box warning for HRT
This is still a very dangerous move- it still needs a warning. There are women who now believe that HRT has no connection whatsoever with cancer, that bioidentical hormones are actually a new thing- that they are better than "older synthetic" hormones and that everything is just perfectly safe, but actually it's just a marketing term. And that just isn't true! Hormones are still a risk/ benefit medication and there's a lot of nuance regarding this.
Women are working longer, living longer, and want to remain relevant longer. That's all good. But menopause happens earlier than everyone expects and we all know it ages us.Everyone has piled on this as if older women were lied to. They weren't. They are still hormones.
HRT is huge industry. It's not a panacea.
Women are working longer, living longer, and want to remain relevant longer. That's all good. But menopause happens earlier than everyone expects and we all know it ages us.Everyone has piled on this as if older women were lied to. They weren't. They are still hormones.
HRT is huge industry. It's not a panacea.
Anonymous
11/12/2025 20:27
Subject: Re:FDA removed black box warning for HRT
Anonymous wrote:Let’s get some education backed discussion going.
The original capital HRT was… conjugated equine estrogens (CEE), often sold under the brand name Premarin®.
For women who still had their uterus, a progestin was added to the estrogen to prevent endometrial cancer. The standard combination was CEE plus medroxyprogesterone acetate (MPA), the active ingredient in Provera®, which was often prescribed together as the combined pill Prempro.
It was a high dose, pill form, in women around 60.
Now being offered … 17β-estradiol, which has the same chemical structure as the primary estrogen produced by the human ovaries (making it "bioidentical"), rather than animal-derived or synthetic estrogens. This is available in various forms, including pills (e.g., Estrace, Gynodiol), patches (e.g., Vivelle-Dot, Minivelle), gels, and sprays.
What we really need is more money towards women research .. research that was cancelled last Spring.
Exactly! The key is the new HRT is bioidentical---better suited for most women.
And yes, we need more research. If men went thru menopause, we would have tens of excellent choices decades ago (just look at all the forms of viagra readily available)
Anonymous
11/12/2025 20:26
Subject: FDA removed black box warning for HRT
Anonymous wrote:Anonymous wrote:Anonymous wrote:Anonymous wrote:Anonymous wrote:Anonymous wrote:I don’t trust anything RFK jr or trump says. This FDA is currently SUS so I’m seeing this as a red flag. If they promote it, I should not consider it.
If it was legitimately safe, Melania should have made the announcement. Woman to women.
I’ll wait until we have actual medical experts back in the FDA before I trust their advice.
Wow - you would have given it more credence out of Melania’s mouth? That’s moronic.
HRT has enabled me to sleep through the night regularly for the first time in a year. Game changer.
And has increased your risk of stroke and cancer.
Well, my thyroid stopped working in my 20s and I need thyroid replacement hormone for the rest of my life to function because my body doesn’t make thyroid hormone anymore. Does that raise my risk of stroke and cancer? I don’t know, maybe. But I’d rather die than live half dead. I don’t see how it’s different with progesterone and estrogen.
You don’t see how thyroid hormones and estrogen/progesterone are different? Ok.
They are both hormones our bodies need (as females). Women are 3-4 times "healthier" and at less risk for serious issues that typically kill men (think heart attack/stroke/etc), until we go thru menopause. Then our rates skyrocket and we become "very unhealthy" because the lack of hormones. Get on the proper hormones and you can be happier and healthier in many ways.
I don't want to live from early 50s until 85/90 without those hormones. With them, I'll take the risks that might come (of which apparently they are minimal). Most of you take way more risks with drinking and eating crap and not exercising, yet don't care to change that
Are you under the impression you will take HRT until you are 95?
Anonymous
11/12/2025 20:25
Subject: FDA removed black box warning for HRT
Anonymous wrote:Anonymous wrote:Anonymous wrote:Anonymous wrote:Anonymous wrote:I don’t trust anything RFK jr or trump says. This FDA is currently SUS so I’m seeing this as a red flag. If they promote it, I should not consider it.
If it was legitimately safe, Melania should have made the announcement. Woman to women.
I’ll wait until we have actual medical experts back in the FDA before I trust their advice.
Wow - you would have given it more credence out of Melania’s mouth? That’s moronic.
HRT has enabled me to sleep through the night regularly for the first time in a year. Game changer.
And has increased your risk of stroke and cancer.
Well, my thyroid stopped working in my 20s and I need thyroid replacement hormone for the rest of my life to function because my body doesn’t make thyroid hormone anymore. Does that raise my risk of stroke and cancer? I don’t know, maybe. But I’d rather die than live half dead. I don’t see how it’s different with progesterone and estrogen.
You don’t see how thyroid hormones and estrogen/progesterone are different? Ok.
They are both hormones our bodies need (as females). Women are 3-4 times "healthier" and at less risk for serious issues that typically kill men (think heart attack/stroke/etc), until we go thru menopause. Then our rates skyrocket and we become "very unhealthy" because the lack of hormones. Get on the proper hormones and you can be happier and healthier in many ways.
I don't want to live from early 50s until 85/90 without those hormones. With them, I'll take the risks that might come (of which apparently they are minimal). Most of you take way more risks with drinking and eating crap and not exercising, yet don't care to change that
Anonymous
11/12/2025 20:22
Subject: FDA removed black box warning for HRT
Anonymous wrote:Anonymous wrote:Anonymous wrote:Anonymous wrote:I don’t trust anything RFK jr or trump says. This FDA is currently SUS so I’m seeing this as a red flag. If they promote it, I should not consider it.
If it was legitimately safe, Melania should have made the announcement. Woman to women.
I’ll wait until we have actual medical experts back in the FDA before I trust their advice.
Wow - you would have given it more credence out of Melania’s mouth? That’s moronic.
HRT has enabled me to sleep through the night regularly for the first time in a year. Game changer.
And has increased your risk of stroke and cancer.
Well, my thyroid stopped working in my 20s and I need thyroid replacement hormone for the rest of my life to function because my body doesn’t make thyroid hormone anymore. Does that raise my risk of stroke and cancer? I don’t know, maybe. But I’d rather die than live half dead. I don’t see how it’s different with progesterone and estrogen.
+1000
I also have a few drinks each week (sometimes more, sometimes less). It's a risk I'm willing to take. Figure I eat clean, tons of fruits and veggies, avoid most carbs except in fruits and veggies (so no empty calories), exercise (walk most places, rarely drive), have always been normal weight (except post pregnancy for 12-15 months), the HRT allows me to actually sleep 7-8 hours without being wide awake for 2 hours at 2am, I Breastfeed for total of 5 years (across 2 kids), had first kid at 30, 2nd at 34. So I've got a lot of "good things" going for me. But the progesterone (orally) and estrogen patch are a lifesaver and I'm now a person who is happy to live (Oh and I get the thyroid issues---I have them and was able to manage with food most of the time, but man when you get a flare, it's a nasty few days sometimes)
So yeah, it's about quality of life.
Anonymous
11/12/2025 20:17
Subject: FDA removed black box warning for HRT
Anonymous wrote:Anonymous wrote:I also don’t trust this administration on health advice but other countries do seem to agree (for example: https://www.nhs.uk/medicines/hormone-replacement-therapy-hrt/)
But I’m still hesitant. My mother had a history of blood clots. And I’m ok with my menopause symptoms so far (I’ve had a bit of weight gain and hot flashes/insomnia but it’s not terrible). I also run a lot and think my muscle tone and bone density is pretty good.
Every time I get annoyed by hot flashes and consider HRT, I reflect on how much worse a stroke would be, then go back to my normal self care exercise and meditation routine.
You can use an estrogen patch and there is no risk of a stroke (that's with the oral estradiol), and find a provider who will prescribe bioidentical progesterone as well. Take both and you will help yourself and not have stroke risks
Anonymous
11/12/2025 18:19
Subject: FDA removed black box warning for HRT
Anonymous wrote:Anonymous wrote:Anonymous wrote:Anonymous wrote:Anonymous wrote:Anonymous wrote:Anonymous wrote:Anonymous wrote:Anonymous wrote:I don’t trust anything RFK jr or trump says. This FDA is currently SUS so I’m seeing this as a red flag. If they promote it, I should not consider it.
If it was legitimately safe, Melania should have made the announcement. Woman to women.
I’ll wait until we have actual medical experts back in the FDA before I trust their advice.
Wow - you would have given it more credence out of Melania’s mouth? That’s moronic.
HRT has enabled me to sleep through the night regularly for the first time in a year. Game changer.
And has increased your risk of stroke and cancer.
Well, my thyroid stopped working in my 20s and I need thyroid replacement hormone for the rest of my life to function because my body doesn’t make thyroid hormone anymore. Does that raise my risk of stroke and cancer? I don’t know, maybe. But I’d rather die than live half dead. I don’t see how it’s different with progesterone and estrogen.
You don’t see how thyroid hormones and estrogen/progesterone are different? Ok.
Why are estrogen/progesterone sacrosanct? One hormone is okay but not the other?
I had intense throwing up level menstrual cramps as a teen. BC was the miracle solution. Yet, those cramps were natural. Should I have just suffered?
Ffs. Nobody said any hormone is “sacrosanct.” The point is that your thyroid failing in your 20s is totally different from menopause in your 50s. To compare the two is nonsensical.
I don’t think anyone is suggesting that people go on HRT for the rest of their lives. Often it’s for a specific time span until your symptoms subside. If you don’t have bothersome symptoms, don’t take it.
Again … missing the point. I’m not saying anything about the length of time. I’m saying they are totally different parts of your body and totally different medically. It only makes sense to compare them if you somehow believe that all “hormones” are the same. Which would be very dumb.
Yes, they are totally different parts of the body and totally different medically. One would take them, or not, after consulting with their doctor and assessing their specific symptoms and risk profile.
Anonymous
11/12/2025 17:08
Subject: FDA removed black box warning for HRT
Anonymous wrote:Anonymous wrote:Anonymous wrote:Anonymous wrote:Anonymous wrote:Anonymous wrote:Anonymous wrote:Anonymous wrote:I don’t trust anything RFK jr or trump says. This FDA is currently SUS so I’m seeing this as a red flag. If they promote it, I should not consider it.
If it was legitimately safe, Melania should have made the announcement. Woman to women.
I’ll wait until we have actual medical experts back in the FDA before I trust their advice.
Wow - you would have given it more credence out of Melania’s mouth? That’s moronic.
HRT has enabled me to sleep through the night regularly for the first time in a year. Game changer.
And has increased your risk of stroke and cancer.
Well, my thyroid stopped working in my 20s and I need thyroid replacement hormone for the rest of my life to function because my body doesn’t make thyroid hormone anymore. Does that raise my risk of stroke and cancer? I don’t know, maybe. But I’d rather die than live half dead. I don’t see how it’s different with progesterone and estrogen.
You don’t see how thyroid hormones and estrogen/progesterone are different? Ok.
Why are estrogen/progesterone sacrosanct? One hormone is okay but not the other?
I had intense throwing up level menstrual cramps as a teen. BC was the miracle solution. Yet, those cramps were natural. Should I have just suffered?
Ffs. Nobody said any hormone is “sacrosanct.” The point is that your thyroid failing in your 20s is totally different from menopause in your 50s. To compare the two is nonsensical.
Is it more nonsensical than posting cherry-picked facts about potential risks while deliberately ignoring the data that suggest HRT lowers all-cause mortality?
All medical societies say that there are risks.
Anonymous
11/12/2025 17:07
Subject: FDA removed black box warning for HRT
Anonymous wrote:Anonymous wrote:Anonymous wrote:Anonymous wrote:Anonymous wrote:Anonymous wrote:Anonymous wrote:Anonymous wrote:I don’t trust anything RFK jr or trump says. This FDA is currently SUS so I’m seeing this as a red flag. If they promote it, I should not consider it.
If it was legitimately safe, Melania should have made the announcement. Woman to women.
I’ll wait until we have actual medical experts back in the FDA before I trust their advice.
Wow - you would have given it more credence out of Melania’s mouth? That’s moronic.
HRT has enabled me to sleep through the night regularly for the first time in a year. Game changer.
And has increased your risk of stroke and cancer.
Well, my thyroid stopped working in my 20s and I need thyroid replacement hormone for the rest of my life to function because my body doesn’t make thyroid hormone anymore. Does that raise my risk of stroke and cancer? I don’t know, maybe. But I’d rather die than live half dead. I don’t see how it’s different with progesterone and estrogen.
You don’t see how thyroid hormones and estrogen/progesterone are different? Ok.
Why are estrogen/progesterone sacrosanct? One hormone is okay but not the other?
I had intense throwing up level menstrual cramps as a teen. BC was the miracle solution. Yet, those cramps were natural. Should I have just suffered?
Ffs. Nobody said any hormone is “sacrosanct.” The point is that your thyroid failing in your 20s is totally different from menopause in your 50s. To compare the two is nonsensical.
I don’t think anyone is suggesting that people go on HRT for the rest of their lives. Often it’s for a specific time span until your symptoms subside. If you don’t have bothersome symptoms, don’t take it.
Again … missing the point. I’m not saying anything about the length of time. I’m saying they are totally different parts of your body and totally different medically. It only makes sense to compare them if you somehow believe that all “hormones” are the same. Which would be very dumb.
Anonymous
11/12/2025 14:25
Subject: FDA removed black box warning for HRT
Anonymous wrote:Anonymous wrote:Anonymous wrote:Anonymous wrote:Anonymous wrote:Anonymous wrote:Anonymous wrote:I don’t trust anything RFK jr or trump says. This FDA is currently SUS so I’m seeing this as a red flag. If they promote it, I should not consider it.
If it was legitimately safe, Melania should have made the announcement. Woman to women.
I’ll wait until we have actual medical experts back in the FDA before I trust their advice.
Wow - you would have given it more credence out of Melania’s mouth? That’s moronic.
HRT has enabled me to sleep through the night regularly for the first time in a year. Game changer.
And has increased your risk of stroke and cancer.
Well, my thyroid stopped working in my 20s and I need thyroid replacement hormone for the rest of my life to function because my body doesn’t make thyroid hormone anymore. Does that raise my risk of stroke and cancer? I don’t know, maybe. But I’d rather die than live half dead. I don’t see how it’s different with progesterone and estrogen.
You don’t see how thyroid hormones and estrogen/progesterone are different? Ok.
Why are estrogen/progesterone sacrosanct? One hormone is okay but not the other?
I had intense throwing up level menstrual cramps as a teen. BC was the miracle solution. Yet, those cramps were natural. Should I have just suffered?
Ffs. Nobody said any hormone is “sacrosanct.” The point is that your thyroid failing in your 20s is totally different from menopause in your 50s. To compare the two is nonsensical.
Is it more nonsensical than posting cherry-picked facts about potential risks while deliberately ignoring the data that suggest HRT lowers all-cause mortality?
Anonymous
11/12/2025 12:28
Subject: FDA removed black box warning for HRT
Anonymous wrote:Anonymous wrote:Anonymous wrote:Anonymous wrote:Anonymous wrote:Anonymous wrote:Anonymous wrote:I don’t trust anything RFK jr or trump says. This FDA is currently SUS so I’m seeing this as a red flag. If they promote it, I should not consider it.
If it was legitimately safe, Melania should have made the announcement. Woman to women.
I’ll wait until we have actual medical experts back in the FDA before I trust their advice.
Wow - you would have given it more credence out of Melania’s mouth? That’s moronic.
HRT has enabled me to sleep through the night regularly for the first time in a year. Game changer.
And has increased your risk of stroke and cancer.
Well, my thyroid stopped working in my 20s and I need thyroid replacement hormone for the rest of my life to function because my body doesn’t make thyroid hormone anymore. Does that raise my risk of stroke and cancer? I don’t know, maybe. But I’d rather die than live half dead. I don’t see how it’s different with progesterone and estrogen.
You don’t see how thyroid hormones and estrogen/progesterone are different? Ok.
Why are estrogen/progesterone sacrosanct? One hormone is okay but not the other?
I had intense throwing up level menstrual cramps as a teen. BC was the miracle solution. Yet, those cramps were natural. Should I have just suffered?
Ffs. Nobody said any hormone is “sacrosanct.” The point is that your thyroid failing in your 20s is totally different from menopause in your 50s. To compare the two is nonsensical.
I don’t think anyone is suggesting that people go on HRT for the rest of their lives. Often it’s for a specific time span until your symptoms subside. If you don’t have bothersome symptoms, don’t take it.