^ I also don’t want to have to take something the rest of my life

Anonymous wrote:Is anyone afraid of the inevitable news report that they are found to cause x,y,z? This is what keeps me from trying them out.

I always wait a long time to see.

I waited years before trying Botox. I only get it twice a year.

I’ve seen some bad outcomes on glp-1 on some women that weren’t heavy prior to starting it. They look like they have wasting disease (brittle, toothpick legs, look older- we are in our 50s). I have been reading about studies if new drugs where they don’t waste the muscle as much.

I’m fit - been an athlete, weight lifter etc my whole life. I gained a little weight (5-8 pounds) in my early 50s but for now was able to take it off by adding an hour walk at the end of the day (in addition to whatever workout I did earlier in the day) and eating more protein. I find a tablespoon of psyllium husk in a glass of water also makes me feel full and less likely to snack too much.

I’m not opposed to glp-1 if I ever were gaining rapidly and not being able to lose it the usual ways. It is a lot of work to maintain weight- but it’s also healthy activities for the body that build strength and reduce risk of disease—the lifestyle choice of always moving and eating good things.

Anonymous wrote:Is anyone afraid of the inevitable news report that they are found to cause x,y,z? This is what keeps me from trying them out.

No. It’s a new class of drugs that have been found to have very little side effects. There are even newer drugs in development now that solve some of the problems these drugs have - for example, there are drugs being developed for the maintenance of weight loss, and drugs being developed that reduce the frequency you have to take them. From 1x a week to 1x a month. Also drugs that are being developed orally instead of injectables

There will be an explosion of people taking them because they’re so well tolerated. The health risks of being overweight and obese are significant enough where it’s easy choice to take GLP-1’s.

Anonymous wrote:How do these medications work? Do people still need to diet or does it do the work for you?

Yes, you still have to diet (or otherwise eat less). It's just easier because you don't feel as ravenous all the time.

Is anyone afraid of the inevitable news report that they are found to cause x,y,z? This is what keeps me from trying them out.

How do these medications work? Do people still need to diet or does it do the work for you?

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Anonymous wrote:I’ve heard horror stories about it causing major digestive issues—either severe constipation or the opposite—and that gives me pause every time I think about trying it. I’ve been fighting to loose an extra 15 pounds of menopause weight for while now.

Zepbound doesn’t seem to cause the same kind of side effects that the first GLP meds did. I tried Wegovy and was always nauseous and constipated. I did lose weight but I was tired of feeling bad. Now I’m on a low dose of Zepbound to maintain my weight and I’ve had zero side effects. Maybe a little bit tired the first 2-3 weeks but now I feel great, it keeps my appetite down, and no digestive issues.

Zero side effects here as well. I feel perfectly normal.

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Anonymous wrote:DH was at first mortified when I took it to lose 15 lbs (ended up losing 25, now at my high school weight and feel great), so after going off on me he got if for himself and lost 20. Both micro dosing indefinitely now. It feels so nice to no longer be consumed by thoughts of food, and to run fast without carrying extra weight. I do kinda think people who need to lose weight and are judging instead of trying it are kinda suckers.

At this point, if I have sit next to a fat person in an airplane and that person is taking a seat and half, I’m going to be angry. There is no excuse to be fat anymore. Take the GLP and stop inflicting your fatness on others.

+1. Fat people are gross, and even 15 pounds overweight looks disgusting these days. Agree that there is no excuse to be overweight. If your doctor doesn’t prescribe, get a new doctor.

Found the MAGA-always rude and you and your words are disgusting inside and out.

Anonymous wrote:I’ve just started on it and I’m hoping to lose 15 pounds. A few people have mentioned microdosing. How much is that typically? My dose is already pretty low. I’m getting mine through Noom.

I've lost just over 20 lbs on Zepbound (went from 145 lbs at 5'7 to 124 lbs in about three months) and am now taking 1 mg per week for maintenance. I think I will never stop. I tried to taper back to 1 mg every two weeks but went back to my binge eating ways by the end of the 2 weeks. Those hunger pangs drive me mad and always have. I mourn the years of my life that I suffered with a cycle of binging and restricting and hating myself. Zepbound quiets the food obsession and dulls the hunger; it is wonderful and feels miraculous. I eat a normal sized meal and feel comfortably full for hours. I am so happy I started the med because for the first time in my entire adult life, I feel I can be slim effortlessly.

I think it's great that your friends are honest about taking it. I tell not a soul. I am on compounded.

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Anonymous wrote:DH was at first mortified when I took it to lose 15 lbs (ended up losing 25, now at my high school weight and feel great), so after going off on me he got if for himself and lost 20. Both micro dosing indefinitely now. It feels so nice to no longer be consumed by thoughts of food, and to run fast without carrying extra weight. I do kinda think people who need to lose weight and are judging instead of trying it are kinda suckers.

Anybody passing judgement has a personality defect - including you. I could easily say you are a sucker for spending money on a drug to alter your biochemistry without having a full picture of the long term consequences. And you are still going to get destroyed by anybody in a running event that didn’t need drugs to be lean, so we have that.

You sound like an idiot. No one is altering their biochemistry, but nice try. And the long term consequences of these drugs have been studied for years so no surprise there.

compounded drugs have not been studied for years.

Are you seriously a moron? Compounded drugs have been available for decades. Compounded semulglutide is no different.

Ignorant is a bliss.

https://www.fda.gov/drugs/postmarket-drug-safety-information-patients-and-providers/fdas-concerns-unapproved-glp-1-drugs-used-weight-loss

Not ignorant of this at all but again nice try. Many reputable pharmacies will provide compounded semulglutide just like that have provided compounded drugs for decades. If you have a good primary care and trust your pharmacy there is absolutely zero problem. You know that but want just be a fear monger out of some weird jealously. It’s like you don’t want deserving people to have access to this drug. The US healthcare system is f’d and absolutely zero reason these name brand drugs should be so expensive. They are not this expensive in Canada or other countries. Pharmaceutical companies are simply taking advantage of our f’d up system to charge more So yea, I’ll get the same drug “ compounded” by a reputable pharmacy and pay half the amount. It works for me and millions of others so stop spreading fear.

I've been on it for a for a year for diabetes. I'm still fighting to lose the last 5 lbs, but my A1C is better.

Everyone with money is on it. If you don't want to be be on it, good for you. Don't judge. One day we will all be dead. Hopefully skinny and happy.

Anonymous wrote:As a scientist with experience in drug regulation I wouldn’t used any of these compounded GLP. These drugs are not regulated at all. Most people using compounded GLP are not even aware of this fact.

If you can afford approved GLP then go for it.

I have been on compound for 2 years. My doctor is the one who told me about compounding and started me on it. She also taught me about the FDA drug regulation process and how it is a joke.

She is the best.

I am not obese but need to lose 20 pounds to be my optimal weight. Where do I get a prescription? Will a medical weight loss place just prescribes it to anyone?

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Anonymous wrote:Go for it but watch your hair! I experienced hair loss and no it wasn’t from rapid weight loss.

This was temporary for me (zepbound). My hair is the same now as when I started.

+1