Anonymous wrote:

Anonymous wrote:I'm surprised that Cornell hasn't made changes to your protocol. Who are you working with?

My DW worked with Dr. Davis at Cornell. She got pregnant twice with day 3 fresh transfer with co-culture, but miscarried both.

She then went on to bring in Dr. Braverman for immune issues and had success at Cornell with an FET with a 2pn embryo (transferred two, one stuck).

Why isn't Cornell doing a fresh day 3 transfer for you?

Can you please tell me about immune issues?

Exploring immune issues can certainly be a rabbit hole, but when you're at the end of your rope and wanting to make sure you've exhausted all options, this is the route to take. We knew that we wouldn't be satisfied moving on until we tried the "kitchen sink approach" (enter Dr. Braverman summer 2016). My wife had issues with MTHFR and also some clotting issues that required lovenox. Their practice often recommends a lap for silent endo - she did that too. They did find some endo on her ovaries and a few other places. She also took metformin and neupogen, both of which are supposed to help with egg quality.

My opinion is that if every woman who had even a little trouble getting pregnant ran an immune panel, something would come back as being "wrong" for pretty much everyone. The question that remains unanswered for us is how much should we attribute her success to immune drugs vs. working at an amazing facility (Cornell) vs. just pure luck and it was our time.

Op here. I had few consults at different places. No one seems to know what the exact problem is (egg or sperm). I tested for immune at abbasi. They found some clotting and minor immune issues, enough to treat, but not enough to explain the problems. I'm still not sure what to do. We both started taking a whole cocktail of supplements and are waiting for 3 months and then we will probably do one cycle with immune treatment. After that, I don't know. Since we don't know the problem, we don't even know that donor egg is going to fix it. And because I'm still young, no doctor is recommending donor.

Anonymous wrote:I'm surprised that Cornell hasn't made changes to your protocol. Who are you working with?

My DW worked with Dr. Davis at Cornell. She got pregnant twice with day 3 fresh transfer with co-culture, but miscarried both.

She then went on to bring in Dr. Braverman for immune issues and had success at Cornell with an FET with a 2pn embryo (transferred two, one stuck).

Why isn't Cornell doing a fresh day 3 transfer for you?

Can you please tell me about immune issues?

Hi OP.

I am in the same boat as you are in (poor quality embryos never making blasts, multiple cycles), except I never had miscarriages because I never got pregnant/made to transfer.

I was "discharged" from SGF with recommendations to go to CCRM because they have a different lab and maybe our embryos would reach blast over there.

I have a pending new-patient appointment at CCRM later this month.

What did you decide to do?

my vote: move on to donor egg. 10 IVF cycles (and through different clinics) is a lot. Once your pregnant, I highly doubt you'll regret going the DE route. Good luck!

I don't know that they are bad quality. They were never tested. Most of my cycles were done in my late 20s and early 30s, so they shouldn't have been terrible. It's that they usually arrest in a lab at day 4 and never really make it to blast. No one knows why except for some vague sometimes embryos don't grow in a lab. I've usually done low dose antagonist. Last bunch of cycles I added clomid in the beginning. I usually transfer day 3. I have had a couple miscarriages on the protocol with clomid but mostly bfn.