OP here, so logistically this is how it goes. First you and your partner do the one day work up (this is only scheduled after you do the phone consultation). The one day work up has to be done at a particular point in your cycle so there is a timing issue. The one day work up is really all day and they take a crazy amount of blood - it was 11 vials for me. It wasn't too onerous though compared to a cycle so we made a long weekend out of it and went to Aspen.
Once all the tests are done they send you your protocol. I have DOR so each cycle consisted of one month of priming (testosterone gel and progesterone) and then one month for the actual IVF cycle. I did all my cycles back to back so three cycles would be six months. So I had my one day in June and my first cycle in September (priming in August), so it was really about six weeks from the one day work up to the start of priming.
As for local monitoring, a local clinic does the first two monitoring sessions. The first is the baseline like a day or two after your cycle starts (the ivf cycle not during priming obviously) and then another one about a week in. Based on that second monitoring CCRM will tell you what to do. But every time I went to Denver two days after that. But my cycles all progressed relatively quickly. I spent about a week on average in Denver. The first day they do their own baseline monitoring to confirm where you really are in follicle development. I found almost every time that CCRM did a more thorough job on monitoring than the local clinic. Based on that first ultrasound you keep coming in until the retrieval. Each time my husband would come out to Denver a day and a half before retrieval. That way he would definitely be there to provide a fresh sample. But you could also freeze samples on another visit or get one sent (but we never did that because it is difficult to do). It was important to have him there to take me to the retrieval (because you're under anesthesia) and he usually gave me the trigger shot. On several of my cycles I used a nurse to help me with my shots. I had trouble giving myself the shots for a while, a mental thing, so having the nurse come to the hotel room was really helpful. CCRM can give you the names of nurses who will come to your hotel. Also, you're doing blood work the whole time locally and in Denver. I did mine at Labcorp at home and that part was pretty easy.
As you can gather, this is a tremendous undertaking. All of the unpredictability with the cycles means you are always taking last minute flights to Denver and you never know exactly when you are coming back. Planning anything in your life is really hard. You can do stuff during the priming cycle pretty easily though.
I've been thinking about trying again (since I have no frozen embryos left) but frankly the amount of work it takes is the major stumbling block for me. It takes a lot of energy to go through. You also can't discount the effects of the altitude. I had altitude sickness on one of my visits, and coupled with how run down the cycle made me, I felt just awful. Some cycles I felt ok and managed to do stuff in Denver but the dryness and altitude really messed with me in a way I didn't anticipate.
Just know this will eat your life and is tremendously expensive (just the travel is crazy) but if you're really committed, it could be worth it. And if you can get through it, it makes having an infant seem not so hard