The Synergistic Effects of APOE Genotype and Obesity on Alzheimer’s Disease Risk

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6337558/

The APOE gene has three common alleles—E2, E3, and E4, with APOE4 being the strongest genetic risk factor for developing Alzheimer’s Disease (AD). Obesity is a global epidemic and contributes to multiple metabolic problems. Obesity is also a risk factor for cognitive decline. Here, we review the effects of APOE4 and obesity on cognition and AD development, independently and together. We describe studies that have associated APOE4 with cognitive deficits and AD, as well as studies that have associated obesity to cognitive deficits and AD. We then describe studies that have examined the effects of obesity and APOE genotypes together, with a focus on APOE4 and high fat diets. Both human studies and rodent models have contributed to understanding the effects of obesity on the different APOE genotypes, and we outline possible underlying mechanisms associated with these effects. Data across approaches support a model in which APOE4 and obesity combine for greater detrimental effects on metabolism and cognition, in ways that are influenced by both age and sex.

I am convinced some of this has to be ApoE4 influence, especially if one is overweight since this allele original gave an evolutionary advantage. Better lipid retention and less infection what's not to like if life expectancy is < 50 years. Modern life pushes the same cohort into a dementia though.

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:From your post you are, in fact, CONSTANTLY sick. You are just used to being sick every day you think it’s normal. From your lack of sleep to your mental health. your diet and obesity is a significant contributing factor to your sleep and mental health issues. Your heart is likely working extremely overtime and will give out sooner than you hope.

skinny beeches always want this to be true to justify their lack of calories, and it's usually not.

My heart health was WAY worse when I was anorexic than it is now that I'm "obese", and my cholesterol is enviable.

Die mad and hungry.

Whatever makes you feel better in justifying your obesity...and your "enviable cholesterol"

NP. No one has to justify their weight to you. What an odd perspective.

Exactly!

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:From your post you are, in fact, CONSTANTLY sick. You are just used to being sick every day you think it’s normal. From your lack of sleep to your mental health. your diet and obesity is a significant contributing factor to your sleep and mental health issues. Your heart is likely working extremely overtime and will give out sooner than you hope.

skinny beeches always want this to be true to justify their lack of calories, and it's usually not.

My heart health was WAY worse when I was anorexic than it is now that I'm "obese", and my cholesterol is enviable.

Die mad and hungry.

Whatever makes you feel better in justifying your obesity...and your "enviable cholesterol"

Nobody has to justify their body, dipshit. Do you. Mind your own business. You'll live a longer, happier life that way!

Anonymous wrote:I am similar age and lifestyle and overweight. When I was in college I worked in daycares for a few years and got sick all the time and I would get really sick each time. After a couple years, I stopped getting sick and have never been that sick since. I swear all the exposure to all those germs built up some kind of immunity.

Yes -- this is what I am talking about (PP)

OP, I'm a lot like you but older. How long have you worked in an elementary school, and are you working as a teacher or someone with contact with kids? If so, do you recall your first five years of teaching?

Many elementary school and preschool teachers report getting sick a lot those first few years. There are a certain number of very common viruses out there. My numbers are completely hypothetical but say it's 150. As a child of course you got exposed to the normal amount that kids get, say 5 a year until they are 10 years old = 50. Then you won't get those anymore because you have already been exposed to them and your body reacts quickly to kill the infection, right?

So as a teen/college/adult you now maybe just get 1 or 2 a year whenever it happens to come into contact with you. Gradually building up exposure to the remaining 100.

Well, all that changes if you work with kids. They bring stuff to school, lots of different cold germs, and you will get them too. So new teachers might also get ill 10 times a year for a while. They just are exposed to a lot more, all at once.

After a while, though, it's like there's nothing those kids can throw at you that your body hasn't seen before. So it's not that you have some super immunity, you just have already been through it so your body recognizes it.

I’m borderline overweight, similarly lax about hand washing, etc. I was sick maybe once every five years before kids; now with toddlers maybe a couple times a year. Even when I get cold it’s only ever 1-5 days of feeling bad. I can’t remember the last time I had a fever. I think some people (us) just have heartier immune systems than others. And good luck. I thank my peasent ancestors for their hearty genetics and hope it continues; I’m not looking forward to being older and frailer and felled by colds as I’m sure will happen eventually.

I am similar age and lifestyle and overweight. When I was in college I worked in daycares for a few years and got sick all the time and I would get really sick each time. After a couple years, I stopped getting sick and have never been that sick since. I swear all the exposure to all those germs built up some kind of immunity.

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:From your post you are, in fact, CONSTANTLY sick. You are just used to being sick every day you think it’s normal. From your lack of sleep to your mental health. your diet and obesity is a significant contributing factor to your sleep and mental health issues. Your heart is likely working extremely overtime and will give out sooner than you hope.

skinny beeches always want this to be true to justify their lack of calories, and it's usually not.

My heart health was WAY worse when I was anorexic than it is now that I'm "obese", and my cholesterol is enviable.

Die mad and hungry.

Whatever makes you feel better in justifying your obesity...and your "enviable cholesterol"

NP. No one has to justify their weight to you. What an odd perspective.

Anonymous wrote:You may have Hypothyroidism. Immune system could be dysfunctional and in overdrive.

WTF?!!! Hypothyroidism slows your immune system down and you get sick more often. SMH. The crap people say on here that's totally incorrect!!!

Anonymous wrote:You are lucky. I catch everything. I barely leave the house and constantly get sick from either what the kids bring home or from the rare times I got out, which is mainly to the doctors.

Do you wash your hands? Is your house clean and disinfected often?

Anonymous wrote:Were you always like this? I think some people are just born with a robust immune system and some aren’t. I also think that working in a Petrie dish like elementary school (I do as well) helps build up immunity with micro exposures.

That's been proven false!