Anonymous wrote:

Anonymous wrote:My fairly healthy 40ish year old relative took Paxlovid and was fine. No side effects, it made him feel better for a few days and then the disease came back (like Biden), but on the whole it was helpful. I think your kid will be fine either way, but why not take it if she has it.

God I hate responses like this. You have NO idea how he would have fared without it. So you just can't say either way.

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:Slightly off topic- could the rebound we see in Paxlovid be similar to quitting antibiotics early-> infection comes back -> antibiotic resistance & super bugs? Maybe they need to adjust the time one takes Paxlovid?

Never hear anyone discussing this so maybe I'm wrong, but I would avoid taking it unless I'm seriously ill for that reason alone.

That is an excellent question, and a lot of scientists are discussing it. We are not seeing resistance to Paxlovid or significant mutations of the viral genome during the rebound phenomenon, so that's good. No super bugs there. It is unclear whether the rebound is due to the natural progression of Covid itself, a course of Paxlovid that is too short, a direct effect of Paxlovid, or a combination. These are all being looked at as possibilities.

It is expected that the virus will eventually be resistant to Paxlovid due to evolutionary pressure, and we will have to develop other therapeutics. Hopefully this won't happen for some time.

One thing that is important to know: Paxlovid is a medication that works when taken EARLY in the course, before serious illness, to prevent that serious illness. If it is given too late it will not work, so it is entirely appropriate to take it in the 1st 5 days of illness if you qualify, even if your symptoms are very mild.

I took Paxlovid day 1. I got Paxlovid rebound after feeling very well. And then out of nowhere, I could not breathe. If you ask me, it was due to Paxlovid rebound.

Anonymous wrote:No way would I ever take this unless I was an 80yo high-risk patient on their deathbed. The rebound is not worth it.

Anonymous wrote:

Anonymous wrote:Slightly off topic- could the rebound we see in Paxlovid be similar to quitting antibiotics early-> infection comes back -> antibiotic resistance & super bugs? Maybe they need to adjust the time one takes Paxlovid?

Never hear anyone discussing this so maybe I'm wrong, but I would avoid taking it unless I'm seriously ill for that reason alone.

That is an excellent question, and a lot of scientists are discussing it. We are not seeing resistance to Paxlovid or significant mutations of the viral genome during the rebound phenomenon, so that's good. No super bugs there. It is unclear whether the rebound is due to the natural progression of Covid itself, a course of Paxlovid that is too short, a direct effect of Paxlovid, or a combination. These are all being looked at as possibilities.

It is expected that the virus will eventually be resistant to Paxlovid due to evolutionary pressure, and we will have to develop other therapeutics. Hopefully this won't happen for some time.

One thing that is important to know: Paxlovid is a medication that works when taken EARLY in the course, before serious illness, to prevent that serious illness. If it is given too late it will not work, so it is entirely appropriate to take it in the 1st 5 days of illness if you qualify, even if your symptoms are very mild.