Anonymous wrote:I'm so shocked to see all the 29 and early 30's women posting on here...

Not what I expected.

Yep, we have fertility issues too.

IVF #1, age 40
4 eggs
2 mature at retrieval, 2 matured 12 hours later
1 fertilized (plus 1 fertilized abnormally, 1 fertilized but seized before Day 3, 1 failed to fertilize)
1 "beautiful" 8-cell embryo transferred on Day 3
BFN
womp womp

I've had 2 missed miscarriages, which suggests to me that I'm really good at sustaining pregnancies and really crap at producing decent eggs, so I assume that this embryo was probably genetically abnormal.

Gearing up for IVF #2

Anonymous wrote:

Anonymous wrote:IVF #1 age 28 (Long protocol)
12 eggs
9 matured
7 fertilized
4 blasts (5 days) frozen
3 FET all BFN

IVF #2 age 30 (short protocol)
ER tomorrow

14 eggs
9 matured
6 fertilized
6 (3 day 7-8 cells)
all failed growing at day 5

Hi, I also failed to get any blasts with a short (antagonist) protocol. We just finished a second cycle (four months later) using long agonist and the results were much better at every stage. I have high AFC and AMH so quantity is not a problem. Even the first time I had 12 mature eggs. But none made it to blast. my second cycle worked and I had blasts to freeze. I concluded that the short protocol was the problem.

41 years old 6 eggs, 2 transfered 1 frozen ?I

Anonymous wrote:IVF #1 age 28 (Long protocol)
12 eggs
9 matured
7 fertilized
4 blasts (5 days) frozen
3 FET all BFN

IVF #2 age 30 (short protocol)
ER tomorrow

14 eggs
9 matured
6 fertilized
6 (3 day 7-8 cells)
all failed growing at day 5

IVF #1 age 28
12 eggs
9 matured
7 fertilized
4 blasts (5 days) frozen
3 FET all BFN

IVF #2 age 30
ER tomorrow

I was 43 at the time of my final cycle, which was done at my doctor's urging because he underestimated the implantation potential of the embryos I had already banked.

I did estrogen priming with a higher dose of stims than I had done before. Also used HGH for a few days at start of stims and triggered with Lupron. I had more than 20 eggs retrieved, but the physical quality was significantly worse than it was in the cycles I did at 40 and 41. Most embryos arrested in the dish before day five. Three were tested on day five, and one was normal. I never ended up transferring it because we ended up completing our family with a 100% success rate doing transfers from banking cycles I did at 40 and 41.

I realize I was lucky to get a normal at 43, and I have no idea if the higher doses and HGH helped or hurt. I do know that in the cycles where I used the lowest doses with a natural day one start, I had fewer eggs retrieved but a bigger percentage of genetically normal, highly-graded day five blasts. In the cycles where I was put on higher doses of meds, I had more eggs retrieved and more blasts, but fewer normal and more middling grades. Doctor thinks it was just the normal variation that occurs in egg quality from month to month.

35
13 Eggs
9 Mature
4 Fertilized
4 Made it to day 5 blasts

13:45 PP: I'm the PP with all the questions. Thanks for all of the details on your protocol. I'm so sorry for your loss! I've had a loss at 11 weeks and it is very tough (none are easy, though). I hope you are able to pursue a path that feels right.

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:IVF 1 (41 y.o.)
retrieved 12 eggs, 4 mature, 4 fertilized (ICSI), 2 early blasts transferred, 0 frozen, BFN.

IVF 2 (41 y.o.)
retrieved 13 eggs, 8 mature, 8 fertilized (ICSI), 2 early blasts transferred, 0 frozen, BFN.

IVF 3 (42 y.o.)
retrieved 14 eggs, 8 mature, 8 fertilized (ICSI), 4 early morulas transferred on day 3 (with AH), 0 frozen, BFN.

IVF 4 (42 y.o.)
retrieved 12 eggs, 7 mature, 5 fertilized (ICSI), 5 transferred on day 3 (with AH), 0 frozen, BFN.

IVF 5 (42 y.o.)
retrieved 25 eggs, 20 mature, 19 fertilized (ICSI), 3 blasts transferred (untested), 3 frozen and PGS'd, all abnormal, BFP from the fresh untested transfer.

How did you get so many more eggs retrieved in your last IVF? 25 vs. 12 is a lot!

I have AMH of over 3 and some PSOS symptoms but no cysts on ovaries and always had regular periods & ovulation. First cycle for example 25 eggs were growing but they retrieved only 12. Each cycle was a different protocol, until i found what worked: letrozole, metformin, prednisolone, lovenox, omnitrope, neupogen. Everything and the kitchen sink pretty much. This would not be applicable to someone with DOR though...

I am like you with an AMH over 3 at age 42. I have regular periods and ovulation, no cysts. What is PSOS? I just had the basic glucose/insulin tests and everything came back fine, so no metformin for me. Where are you and who are you working with that seems to understand immune issues (Neupogen) and is willing to prescribe Omnitrope? I'm curious about your protocol--was it Letrozole on just five days or all the way through? Did you do any Gonal F or Menopur with that? Sorry for so many questions!

I am the quoted PP. Meant PCOS but made a typo
Both Neupogen and Omnitrop were prescribed by my clinic overseas, I could not find anyone locally who would do these for IVF and was unable to pay out of pocket for Sher or other big name RI clinics. I have to point out though, that I did Omnitrop in one of the earlier cycles too and it made absolutely no difference. Purely based on my gut feeling I think the difference was due to metformin for 3 months prior to the stims and during (i have slightly elevated glucose and also PAI-1 clotting mutation), letrozole and possibly Neupogen. The latter was used more empirically for repeat implantation failure, although I do have some wonky antibodies to scleroderma/polyomyositis. You have to be monitored on it because your blood counts go a bit crazy and also I ended up with OHSS in that cycle. I used neupogen for 16 days only starting from day 2 after retrieval, no extended use in the first trimester. To answer your question about the protocol, it was no suppression, no estrogen priming, plain antagonist with letrozole on days 3-7, follistim days 5-12, menopur days 10-12, cetrotide days 10-13. Hope this is helpful. I am not on yahoo or FB, most of my research was on pubmed for studies and thebump and babycenter for anecdotal evidence. Sadly, my BFP ended up in miscarriage at 11 weeks of a genetically normal embryo, so if we ever do another IVF (which DH is currently against doing), then I guess I'll find out if the good result on this regimen was a fluke or not.

I would also really love to know who to go to to get Omnitrope prescribed. I am a NP (sort of) and I am on both immune groups.

I'm the PP who is 42, AMH over 3 who has so many questions for similar PP: Are you on either the Yahoo or FB groups for immune issues? I would love to connect and could put out a general announcement at either of those places to find you and have a more private exchange if you wish.

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:IVF 1 (41 y.o.)
retrieved 12 eggs, 4 mature, 4 fertilized (ICSI), 2 early blasts transferred, 0 frozen, BFN.

IVF 2 (41 y.o.)
retrieved 13 eggs, 8 mature, 8 fertilized (ICSI), 2 early blasts transferred, 0 frozen, BFN.

IVF 3 (42 y.o.)
retrieved 14 eggs, 8 mature, 8 fertilized (ICSI), 4 early morulas transferred on day 3 (with AH), 0 frozen, BFN.

IVF 4 (42 y.o.)
retrieved 12 eggs, 7 mature, 5 fertilized (ICSI), 5 transferred on day 3 (with AH), 0 frozen, BFN.

IVF 5 (42 y.o.)
retrieved 25 eggs, 20 mature, 19 fertilized (ICSI), 3 blasts transferred (untested), 3 frozen and PGS'd, all abnormal, BFP from the fresh untested transfer.

How did you get so many more eggs retrieved in your last IVF? 25 vs. 12 is a lot!

I have AMH of over 3 and some PSOS symptoms but no cysts on ovaries and always had regular periods & ovulation. First cycle for example 25 eggs were growing but they retrieved only 12. Each cycle was a different protocol, until i found what worked: letrozole, metformin, prednisolone, lovenox, omnitrope, neupogen. Everything and the kitchen sink pretty much. This would not be applicable to someone with DOR though...

I am like you with an AMH over 3 at age 42. I have regular periods and ovulation, no cysts. What is PSOS? I just had the basic glucose/insulin tests and everything came back fine, so no metformin for me. Where are you and who are you working with that seems to understand immune issues (Neupogen) and is willing to prescribe Omnitrope? I'm curious about your protocol--was it Letrozole on just five days or all the way through? Did you do any Gonal F or Menopur with that? Sorry for so many questions!

38 years old -
14 eggs retrieved
13 fully mature one borderline mature
8 inseminated today (VALENTINE'S DAY CONCEPTION!! Woo!)
froze 6 remaining eggs,
Waiting to see how many make it to Day 3 using ICSI

good luck to you all!!

Anonymous wrote:

Anonymous wrote:IVF 1 (41 y.o.)
retrieved 12 eggs, 4 mature, 4 fertilized (ICSI), 2 early blasts transferred, 0 frozen, BFN.

IVF 2 (41 y.o.)
retrieved 13 eggs, 8 mature, 8 fertilized (ICSI), 2 early blasts transferred, 0 frozen, BFN.

IVF 3 (42 y.o.)
retrieved 14 eggs, 8 mature, 8 fertilized (ICSI), 4 early morulas transferred on day 3 (with AH), 0 frozen, BFN.

IVF 4 (42 y.o.)
retrieved 12 eggs, 7 mature, 5 fertilized (ICSI), 5 transferred on day 3 (with AH), 0 frozen, BFN.

IVF 5 (42 y.o.)
retrieved 25 eggs, 20 mature, 19 fertilized (ICSI), 3 blasts transferred (untested), 3 frozen and PGS'd, all abnormal, BFP from the fresh untested transfer.

How did you get so many more eggs retrieved in your last IVF? 25 vs. 12 is a lot!

I have AMH of over 3 and some PSOS symptoms but no cysts on ovaries and always had regular periods & ovulation. First cycle for example 25 eggs were growing but they retrieved only 12. Each cycle was a different protocol, until i found what worked: letrozole, metformin, prednisolone, lovenox, omnitrope, neupogen. Everything and the kitchen sink pretty much. This would not be applicable to someone with DOR though...