Anonymous wrote:I think OP is a bit off, though. "So smiley" is really what folinic acid / folic acid does.

Maybe the kid likes summer vacation.

That's exactly what its supposed to do. Folinic acid helps people with cerebral folate insufficiency by restoring folate levels in the brain, which are critical for producing neurotransmitters like serotonin, dopamine, and norepinephrine—chemicals that regulate mood and emotional responses. As these neurotransmitter systems begin to function more normally, individuals may experience a greater range of emotional sensitivity, including both happiness and sadness. This emotional "awakening" can feel intense at first, especially in those who previously had blunted or flat affect due to low brain folate. It has to be started slowly because of the new, intense feelings

I think OP is a bit off, though. "So smiley" is really what folinic acid / folic acid does.

Maybe the kid likes summer vacation.

Anonymous wrote:

Anonymous wrote:Another troll trying to take advantage of patents of SN children.

It an over the counter vitamin. What's the angle?

DP. Not debating any "angle". FYI:

OTC folinic acid dose is 0.5mg

Prescription leucovorin dose is over 10mg.


Technically you coud self-hypermedicate on OTC doses, but could be risky

It's an active area of research.

Definitive tests for cerebral folate deficiency
involve a spinal tap, but it is easy to get a speculative prescription based on observation.

https://tacanow.org/family-resources/cerebral-folate-deficiency/

I am so happy for you.

This is an amazing study in pendantry and negativity.
The SUNY professor notes a similiar figure at 12:20 https://youtu.be/3DruLBCFxFE?si=NFgzc5FYTw1rtwXC
I guess he's part of the plot? Lol

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:Another troll trying to take advantage of patents of SN children.

DP. Doesn’t sound like a troll to me. Look at the research links.

What's trolly about it is the huge claim "75% of autistic people" with no cite. Best I can tell, there is a study that found 75% of the 93 study participants had it, and a minority of them had some improvement during the treatment.

The NIH study linked here said ONE-THIRD of the 93 children treated with leucovorin showed MODERATE to MUCH IMPROVEMENT.

“ Compared with controls, significantly higher improvement ratings were observed in treated children over a mean period of 4 months in verbal communication, receptive and expressive language, attention and stereotypical behavior. Approximately one-third of treated children demonstrated moderate to much improvement. The incidence of adverse effects was low. This study suggests that FRAs may be important in ASD and that FRA-positive children with ASD may benefit from leucovorin calcium treatment”

Right but someone else provided that, not OP. OP made an assertion with no cite. And in the study you reference, there weren't 93 children treated. It says "In all, 44 children (age mean=6 years 10 months; s.d.=2 years 8 months; range 2 years 11 months to 15 years 0 months) of the 70 FRA-positive (either blocking or binding autoantibody or both) children were treated..." So it's not a very big study and not a very big treatment group. That doesn't make it un-interesting or un-important. But it doesn't support OP's much, much broader assertion that 75% of all individuals with ASD have an underlying immune condition related to folate. Maybe OP has some other study to point to.

Anonymous wrote:Another troll trying to take advantage of patents of SN children.

It an over the counter vitamin. What's the angle?