Anonymous wrote:https://nypost.com/2025/12/12/health/docs-call-for-glp-1-warning-label-due-to-very-dangerous-risk/

Apparently others are noticing this too...

If Americans can overdo something they will absolutely to the greatest degree possible.

https://nypost.com/2025/12/12/health/docs-call-for-glp-1-warning-label-due-to-very-dangerous-risk/

Apparently others are noticing this too...

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:I can't wait to see what the long term effects of GLP1s are. So far they say there are ongoing nausea, constipation, and diarrhea, gallbladder problems, pancreatitis, and thyroid issues. Some mentioned muscle wasting and neurological problems like anhedonia. Sound fun!

But the thing is these side effects need to be balanced against the well known negative effects on your body of obesity. It’s not appropriate for a normal weight celebrity or average person to be on weight loss drugs (but people are still doing it obviously). But for a person who is morbidly obese or just regular obese … the benefits of losing weight outweigh the risks of constipation/diarrhea, muscle wasting, and gallbladder issues that might pop up. Because obese people tend to struggle with those things more than normal weight people anyway so you might as well be normal weight while you have those problems.

Why are you bringing up obesity in a conversation about anorexia?

Because the conversation is about GLP1 medications, which are a treatment for obesity? Not PP, but that seems pretty obvious.

But they aren't only for obese people, they are a subset of people on the drugs.

A "subset"? GLP1 medications are approved to treat diabetes and to treat obesity. GLP1 weight loss meds treat obesity. This "they are a subset of people on the drugs" is nonsense. Are there people who take them who are not obese? Yes. Generally that is because they lie about their BMI on a telehealth call with one of these online providers that look the other way. If people are going to lie to obtain drugs, they are going to lie to obtain drugs. They ARE only for obese people, aside from the small number of people for whom they are prescribed for cardiovascular problems or liver disease. Wegovy is also approved for severe obstructive sleep apnea, but when i asked my sleep doc about it she says the only benefit to sleep apnea is from the weight loss.

Do you lobby for these drugs? I know a ton of people on them who would never qualify as obese. Why would I take your word for it?

You’re projecting, PP. Do you work for the insurance industry?

Has a member of your household ever been formally diagnosed as malnourished? I have, but it wasn't GLP1 related. It is scary. No fat was left in the temples, which I guess is the last place you'll find fat on someone.

My household member "recovered" a year ago, but he will NEVER have the same physical stamina, because of the muscle wasting experienced from that malnutrition.

What concerns me about GLP-1s is the normalization that seems to be happening around the malnourished look. We are expected to sit back and say nothing. As a society we care less and less about people.

Not everyone gets to that malnourished state, I understand that. However, we are quickly losing sight of what healthy looks in the other direction from fat.

Vitamin deficiencies, muscle wasting, etc. really need to be monitored.

Unfortunately, it's going to take a lot of deaths of people abusing the drug before anyone takes action. There is too much money to be made outside of people who genuinely have a need for these drugs.

Anonymous wrote:I can't wait to see what the long term effects of GLP1s are. So far they say there are ongoing nausea, constipation, and diarrhea, gallbladder problems, pancreatitis, and thyroid issues. Some mentioned muscle wasting and neurological problems like anhedonia. Sound fun!

Can you even take GLP1s if you have any of these conditions already? Or for example, if you do not have a gallbladder?

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:I can't wait to see what the long term effects of GLP1s are. So far they say there are ongoing nausea, constipation, and diarrhea, gallbladder problems, pancreatitis, and thyroid issues. Some mentioned muscle wasting and neurological problems like anhedonia. Sound fun!

But the thing is these side effects need to be balanced against the well known negative effects on your body of obesity. It’s not appropriate for a normal weight celebrity or average person to be on weight loss drugs (but people are still doing it obviously). But for a person who is morbidly obese or just regular obese … the benefits of losing weight outweigh the risks of constipation/diarrhea, muscle wasting, and gallbladder issues that might pop up. Because obese people tend to struggle with those things more than normal weight people anyway so you might as well be normal weight while you have those problems.

+1

With any medication the risks and benefits are both weighed. Always. Not sure why people are so beyond confused about this, aside from being blinded by hatred of people in larger bodies.

I think the point is that the massive media and marketing push behind these drugs is such that people aren’t weighing the risks and benefits. They are only focusing on the outcome they want and ignoring and freaking out at any suggestion that caution might be warranted.

Well, it's a good thing "these drugs" aren't OTC then.

Part of the problem is that for all intents and purposes, they are, but that’s another discussion.

Only if you're rich.

Without insurance GLPs are like $2,000 a month. With insurance PBMs are so stingy most plans force you to weigh in on a wifi-enabled scale connected to an app to keep your coverage and they won't even let you stay on for maintenance once you've hit a normal BMI.

It's a nonissue for the vast majority of people because they simply can't afford to abuse them.

You have not been paying attention.

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:I can't wait to see what the long term effects of GLP1s are. So far they say there are ongoing nausea, constipation, and diarrhea, gallbladder problems, pancreatitis, and thyroid issues. Some mentioned muscle wasting and neurological problems like anhedonia. Sound fun!

But the thing is these side effects need to be balanced against the well known negative effects on your body of obesity. It’s not appropriate for a normal weight celebrity or average person to be on weight loss drugs (but people are still doing it obviously). But for a person who is morbidly obese or just regular obese … the benefits of losing weight outweigh the risks of constipation/diarrhea, muscle wasting, and gallbladder issues that might pop up. Because obese people tend to struggle with those things more than normal weight people anyway so you might as well be normal weight while you have those problems.

+1

With any medication the risks and benefits are both weighed. Always. Not sure why people are so beyond confused about this, aside from being blinded by hatred of people in larger bodies.

I think the point is that the massive media and marketing push behind these drugs is such that people aren’t weighing the risks and benefits. They are only focusing on the outcome they want and ignoring and freaking out at any suggestion that caution might be warranted.

Well, it's a good thing "these drugs" aren't OTC then.

Part of the problem is that for all intents and purposes, they are, but that’s another discussion.

Only if you're rich.

Without insurance GLPs are like $2,000 a month. With insurance PBMs are so stingy most plans force you to weigh in on a wifi-enabled scale connected to an app to keep your coverage and they won't even let you stay on for maintenance once you've hit a normal BMI.

It's a nonissue for the vast majority of people because they simply can't afford to abuse them.

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:I can't wait to see what the long term effects of GLP1s are. So far they say there are ongoing nausea, constipation, and diarrhea, gallbladder problems, pancreatitis, and thyroid issues. Some mentioned muscle wasting and neurological problems like anhedonia. Sound fun!

But the thing is these side effects need to be balanced against the well known negative effects on your body of obesity. It’s not appropriate for a normal weight celebrity or average person to be on weight loss drugs (but people are still doing it obviously). But for a person who is morbidly obese or just regular obese … the benefits of losing weight outweigh the risks of constipation/diarrhea, muscle wasting, and gallbladder issues that might pop up. Because obese people tend to struggle with those things more than normal weight people anyway so you might as well be normal weight while you have those problems.

+1

With any medication the risks and benefits are both weighed. Always. Not sure why people are so beyond confused about this, aside from being blinded by hatred of people in larger bodies.

I think the point is that the massive media and marketing push behind these drugs is such that people aren’t weighing the risks and benefits. They are only focusing on the outcome they want and ignoring and freaking out at any suggestion that caution might be warranted.

Well, it's a good thing "these drugs" aren't OTC then.

Part of the problem is that for all intents and purposes, they are, but that’s another discussion.

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:I can't wait to see what the long term effects of GLP1s are. So far they say there are ongoing nausea, constipation, and diarrhea, gallbladder problems, pancreatitis, and thyroid issues. Some mentioned muscle wasting and neurological problems like anhedonia. Sound fun!

But the thing is these side effects need to be balanced against the well known negative effects on your body of obesity. It’s not appropriate for a normal weight celebrity or average person to be on weight loss drugs (but people are still doing it obviously). But for a person who is morbidly obese or just regular obese … the benefits of losing weight outweigh the risks of constipation/diarrhea, muscle wasting, and gallbladder issues that might pop up. Because obese people tend to struggle with those things more than normal weight people anyway so you might as well be normal weight while you have those problems.

Why are you bringing up obesity in a conversation about anorexia?

Because the conversation is about GLP1 medications, which are a treatment for obesity? Not PP, but that seems pretty obvious.

But they aren't only for obese people, they are a subset of people on the drugs.

A "subset"? GLP1 medications are approved to treat diabetes and to treat obesity. GLP1 weight loss meds treat obesity. This "they are a subset of people on the drugs" is nonsense. Are there people who take them who are not obese? Yes. Generally that is because they lie about their BMI on a telehealth call with one of these online providers that look the other way. If people are going to lie to obtain drugs, they are going to lie to obtain drugs. They ARE only for obese people, aside from the small number of people for whom they are prescribed for cardiovascular problems or liver disease. Wegovy is also approved for severe obstructive sleep apnea, but when i asked my sleep doc about it she says the only benefit to sleep apnea is from the weight loss.

Do you lobby for these drugs? I know a ton of people on them who would never qualify as obese. Why would I take your word for it?

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:I can't wait to see what the long term effects of GLP1s are. So far they say there are ongoing nausea, constipation, and diarrhea, gallbladder problems, pancreatitis, and thyroid issues. Some mentioned muscle wasting and neurological problems like anhedonia. Sound fun!

But the thing is these side effects need to be balanced against the well known negative effects on your body of obesity. It’s not appropriate for a normal weight celebrity or average person to be on weight loss drugs (but people are still doing it obviously). But for a person who is morbidly obese or just regular obese … the benefits of losing weight outweigh the risks of constipation/diarrhea, muscle wasting, and gallbladder issues that might pop up. Because obese people tend to struggle with those things more than normal weight people anyway so you might as well be normal weight while you have those problems.

Why are you bringing up obesity in a conversation about anorexia?

Because the conversation is about GLP1 medications, which are a treatment for obesity? Not PP, but that seems pretty obvious.

But they aren't only for obese people, they are a subset of people on the drugs.

A "subset"? GLP1 medications are approved to treat diabetes and to treat obesity. GLP1 weight loss meds treat obesity. This "they are a subset of people on the drugs" is nonsense. Are there people who take them who are not obese? Yes. Generally that is because they lie about their BMI on a telehealth call with one of these online providers that look the other way. If people are going to lie to obtain drugs, they are going to lie to obtain drugs. They ARE only for obese people, aside from the small number of people for whom they are prescribed for cardiovascular problems or liver disease. Wegovy is also approved for severe obstructive sleep apnea, but when i asked my sleep doc about it she says the only benefit to sleep apnea is from the weight loss.

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:I can't wait to see what the long term effects of GLP1s are. So far they say there are ongoing nausea, constipation, and diarrhea, gallbladder problems, pancreatitis, and thyroid issues. Some mentioned muscle wasting and neurological problems like anhedonia. Sound fun!

But the thing is these side effects need to be balanced against the well known negative effects on your body of obesity. It’s not appropriate for a normal weight celebrity or average person to be on weight loss drugs (but people are still doing it obviously). But for a person who is morbidly obese or just regular obese … the benefits of losing weight outweigh the risks of constipation/diarrhea, muscle wasting, and gallbladder issues that might pop up. Because obese people tend to struggle with those things more than normal weight people anyway so you might as well be normal weight while you have those problems.

+1

With any medication the risks and benefits are both weighed. Always. Not sure why people are so beyond confused about this, aside from being blinded by hatred of people in larger bodies.

I think the point is that the massive media and marketing push behind these drugs is such that people aren’t weighing the risks and benefits. They are only focusing on the outcome they want and ignoring and freaking out at any suggestion that caution might be warranted.

Well, it's a good thing "these drugs" aren't OTC then.

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:I can't wait to see what the long term effects of GLP1s are. So far they say there are ongoing nausea, constipation, and diarrhea, gallbladder problems, pancreatitis, and thyroid issues. Some mentioned muscle wasting and neurological problems like anhedonia. Sound fun!

But the thing is these side effects need to be balanced against the well known negative effects on your body of obesity. It’s not appropriate for a normal weight celebrity or average person to be on weight loss drugs (but people are still doing it obviously). But for a person who is morbidly obese or just regular obese … the benefits of losing weight outweigh the risks of constipation/diarrhea, muscle wasting, and gallbladder issues that might pop up. Because obese people tend to struggle with those things more than normal weight people anyway so you might as well be normal weight while you have those problems.

Why are you bringing up obesity in a conversation about anorexia?

Because the conversation is about GLP1 medications, which are a treatment for obesity? Not PP, but that seems pretty obvious.

But they aren't only for obese people, they are a subset of people on the drugs.

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:There are a number of people in my neighborhood and my office who started ozempic/mounjaro/etc. within the last few years. Here’s what I’ve observed:

The ones who were very overweight and older (50+) are now skeletal and saggy. It’s jarring to see someone lose 100+ pounds. I’ve observed others asking “what’s wrong” or if they have cancer, etc.

The ones who were not very overweight and were just a bit pudgy/flabby got skinny and tighter. They look healthy and just don’t eat much anymore.

I’ve observed most obsessing about their weight and complaining how they just can’t eat much anymore. They seem to struggle to eat half a sandwich.

Every time I go to the GYN the practice asks if I want a consult for a GLP1. I’m 5’9” and hover between 175-180. I’m a size 12/14. I gained 30 pounds when perimenopause started. While I’m tempted to take the magic shot, I can’t get past the feeling that it’s damaging to one’s health.

There's been research, study and testing on these drugs going back as far as the '80's. Trials mandated by the FDA to assess cardiovascular risk showed that the drugs actually have a protective effect against cardiovascular disease.

I'm not saying you should consider using a GLP 1 or not, but through science we already know that a healthy BMI reduces disease risk factors and that these drugs have a positive effect on cardiovascular health. Things like muscle loss can be counteracted with weight lifting, which is recommended for women as part of a healthy lifestyle anyway.

These studies haven’t been done in people without diabetes. What I think we will see is a good deal of osteoporosis, malnutrition and possibly some unexpected outcome regarding pancreatic function in those populations. I don’t have faith in a lot of people to have the discipline necessary to eat that much less and make sure their nutritional needs are being properly met. I hope I’m wrong but I’ve lived long enough and seen enough “miracles” be adopted quickly only to see lots of poor, unexpected and often deadly outcomes.

Are people with diabetes not susceptible to osteoporosis and malnutrition (which seems like an absurd claim)?

No one "claimed" that.

And the dosing is different -- any first year med or pharmacy student can tell you that the only difference between medicine and poison is dose.

The PP claimed exactly that - “ What I think we will see is a good deal of osteoporosis, malnutrition…”

As far as the dose - nice quip, but do you have any evidence that short term higher doses of these medications are poison? Or just vibes?

I wrote that post and I didn’t claim anything. I presented suppositions. If you don’t know the difference between a claim and a supposition that’s on you. Why is any comment other than “This is the best drug ever!” received by you as a personal attack?

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:I can't wait to see what the long term effects of GLP1s are. So far they say there are ongoing nausea, constipation, and diarrhea, gallbladder problems, pancreatitis, and thyroid issues. Some mentioned muscle wasting and neurological problems like anhedonia. Sound fun!

But the thing is these side effects need to be balanced against the well known negative effects on your body of obesity. It’s not appropriate for a normal weight celebrity or average person to be on weight loss drugs (but people are still doing it obviously). But for a person who is morbidly obese or just regular obese … the benefits of losing weight outweigh the risks of constipation/diarrhea, muscle wasting, and gallbladder issues that might pop up. Because obese people tend to struggle with those things more than normal weight people anyway so you might as well be normal weight while you have those problems.

+1

With any medication the risks and benefits are both weighed. Always. Not sure why people are so beyond confused about this, aside from being blinded by hatred of people in larger bodies.

I think the point is that the massive media and marketing push behind these drugs is such that people aren’t weighing the risks and benefits. They are only focusing on the outcome they want and ignoring and freaking out at any suggestion that caution might be warranted.

Anonymous wrote:Invest in biotech and drug companies that make treatments for osteoporosis, because it’s about to do its big one with all this extreme weight loss.

These medications, romosozumab, already exist.