In general, no. I have lots of friends (real and facebook) and people seem to like me. I make new friends easily and it's more typical for me to meet cool women at a bar or party than to meet cool men. But I do have a stronger personality, and that means that I can usually list one or two people - usually women - who I know don't like me. I can think of two right now.

If I know the reason and feel like I need to clear something up, I will do so. Not because I can't stand to have someone dislike me- I'm totally fine with that - but because if I've offended someone, I would want to address that, either by apologizing or explaining myself further.
Chances are, if you've ever expressed an opinion that was even slightly controversial, or if you've ever done anything assertively or with confidence, someone probably doesn't like you.
For the record, I don't consider myself beautiful, but I do think I'm at least of average attractiveness. I have a good figure mainly because I work out all the time, but I don't have big boobs or a small butt or anything resembling a model figure, so women aren't likely to be jealous of me for anything looks-related.
There are a few women I actively dislike. I will be polite if I see them in public, but I will generally try to avoid spending any actual time with them. I have some super-hot friends, so that doesn't figure in for me. Most of my friends are smart and quite a few of them are more successful than me, and most have partners while I'm still single. None of those things bother me. For me, if a person is insecure and channels that into being nasty to or about other people, that is my "I don't like her" factor. If someone is constantly attention-seeking, that'll turn me off. If someone gets drunk and out-of-control every time they go out, I will probably hold that against them. I also don't like women who are 90% about the guy and 10% about their friends. Because they'll sell you out for the guy, even if the guy won't be around in 3 months.