Anonymous wrote:OP see a RE. Three MC takes a lot out of you. Hopefully they can help you with your 4th. Best to you.

Thanks so much. This is the OP. I have an apt with Dr. Humm at GW in two weeks. I've heard some rave reviews about her and even the receptionist made me feel supported and informed.

I'm definitely feeling more shaken than I initially did, and am feeling pretty wary of the road ahead.

As I mentioned earlier, I've already tested negative for all the basic things (never thought I'd be so disappointed to have normal thyroid function and no clotting disorder), but I really appreciate some of the suggestions on here for testing that I hadn't heard of before. I feel like I have a list of questions to bring to my first appointment now.

OP see a RE. Three MC takes a lot out of you. Hopefully they can help you with your 4th. Best to you.

Anonymous wrote:My doc told me to take a baby aspirin every day in case it was a blood clotting issue. Also progesterone suppositories as soon as you get a positive. I’m sorry and wish you luck.

This. I’m so sorry.

Go see Dr Abbasi, she will request many of the tests on the list here. https://www.rosalindfranklin.edu/research/researchers/research-facilities/clinical-immunology-lab/ if you scroll down to "Diagnostic Test Menu".

I had 8 losses followed by 3 successful pregnancies once I was on the proper immune protocols.

What exactly should I ask my clinic for regarding immune testing? I've had 4 miscarriages and was on aspirin and progesterone evey time. We've done all the standard testing, and also DNA fragmentation and karyotype testing and all is normal. I'm 41 so that might be the problem.

you may also want to get karyotyping done for you and your spouse. the standard gene testing doesn't catch translocations.

get checked for antiphospholipid antibodies. (this has to do with "thick blood"...if you have it, it's a simple fix, of baby aspirin during some parts of your pregnancy--but not all, aspirin can be dangerous at some parts of the pregancy.) Also know that this condition can come and go. I had it (and miscarried) then when I got pregnant again, it was gone.

Anonymous wrote:MTHFR.

Yes, get checked for this. I had many early miscarriages and this is thought to be a factor. Now have four healthy biological children and
one adopted. Probably 6-8 miscarriages between ages 27-37, I lost track of the exact number.

This was me at 36 and 37. Three miscarriages at 11 weeks, 8 weeks, and 6 weeks. All testing came back fine. I ended up getting pregnant naturally at 38 and that one stuck, I'm now pregnant again at 40 (7 months along). Doctor's couldn't figure out what was wrong but did put me on baby aspirin for the fourth and now fifth pregnancy. That seemed to have done the trick. Like you I had no problem getting pregnant naturally, it was just getting the baby to stick. I say keep trying (include baby aspirin if you haven't already) but keep trying.

To do before next TTC cycle:

1. Blood clotting factor testing; if you pop positive for any simply taking baby aspirin each day can typically help to sustain a pregnancy

2. Ask for Rx for progesterone suppositories or IM injections from date of potential conception until cleared at 10-week mark; they really can and do support early pregnancy

3. Get immune / killer cells testing. It can be tricky to find a lab and provider who can do this, so give yourself plenty of time for your doctor to help with a referral. Treatments could include a dose of antibiotics or immune globulin IV treatment prior to start of TTC / ART cycle


The good news is that you do not have a problem getting pregnant. That is half the battle. Wishing you lots of luck.

Agree with others who have suggested it's time to introduce an immune protocol at this point.

Anonymous wrote:You need to pursue immune testing.

Someone close to me found out after years of fertility treatments that her and her spouse have alloimmunity. It only takes a blood test but not all docs believe in it.

MTHFR.

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:You need to pursue immune testing.

+1 and clotting. I also had 3 miscarriages in a year (after a normal successful pregnancy) and turned out to have both immune and clotting issues. With treatment for both, I carried my next pregnancy to term.

I saw Dr. Abbasi at CFA.

I am PP and also used Dr. Abbasi after trying Shady Grove (6 unsuccessful IUIs with them). Highly recommend.

+1000

I went to Dr. Abbasi and she prescribed progesterone suppositories (even upped the dosage after the first scan). Currently 33 weeks pregnant. Cannot recommend her highly enough.

You probably don’t need IVF. There’s a lot of other things to try first. Even progesterone can help you keep a pregnancy. I’d run your numbers first. It could be age. Miscarriages increase with age. I’m dealing with it myself at 34 too.