Anonymous wrote:

Anonymous wrote:

Anonymous wrote:The trouble is that you might end up having a child with one of those fair to poor embryos. And that child might have significant mental/physical/emotional challenges. If your desire to have a child is greater than your fear of raising a severely disabled one, then go ahead. Because it's not just the idea that it won't take that you have to consider, it's the fact that perhaps the reason they are poor embryos is because they won't make very great persons. The clinic won't tell you this because obviously any baby is a good baby for them - but for you, it's potentially the next sixty years of your life caring for someone who doesn't function well.

No.
There is no correlation between embryo quality and whether or not that embryo is genetically normal. Of my 7 "excellent" day 5 blasts, only 3 of them were PGS normal. Likewise, I know quite a few people with lower quality embryos that resulted in successful pregnancies.

There is absolutely correlation between embryo grades and PGS normal embryos. Here is a nice table from Fertility and Sterility. https://www.fertstert.org/article/S0015-0282(15)01380-1/pdf

Of course, individual lower graded embryos can be PGS normal and perfect AA embryo can be abnormal. But broadly, higher graded embryos are more likely to be PGS normal.

this is not the relevant question. Of course there is a correlation between the grade and normality - that’s why hey do the grading. However the question is if poor looking and great looking embryos made it to a live baby is a poor grades one more likely to have a genetic defect. The answer to that is no.

Op you sound pretty fertile. Go ahead and try. Sooner rather than later.

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:I have the same numbers as you but I'm 40 with a 4 year old child who I got pregnant with right away when I was 35. I have been ttc a sibling for 3 years and no luck but I was told I have mold not severe dor. My afc is 10 maybe that's why

i have a starting AFC of 2-3. For some reason two weeks of estrogen priming before stimming really gets things going for me and I end up with a pretty good haul (For my AMH). it is a LONG protocol though. I usually stim for 14-18 days after two weeks of priming.

What protocol did you use? That's a ton of eggs for those AFCs.

OP Here. Still haven't done anything - all 5 still frozen. DD is almost 3 and I think it's soon or never.

to the protocol question - we did low and slow estrogen priming protocol - 21 days of estrace, (starting day after confirmed ovulation in previous cycle) and started medium does stims on day 5-7 of cycle. I ended up stimming like 20-22 days each cycle ($$$$$$$$) and usually would have to start ganerlix as soon as I had a folicle at 10 or so as my body LOVES to ovulate early. I found that by day 8ish of stims I would magically have tons of follies.

Anonymous wrote:

Anonymous wrote:I have the same numbers as you but I'm 40 with a 4 year old child who I got pregnant with right away when I was 35. I have been ttc a sibling for 3 years and no luck but I was told I have mold not severe dor. My afc is 10 maybe that's why

i have a starting AFC of 2-3. For some reason two weeks of estrogen priming before stimming really gets things going for me and I end up with a pretty good haul (For my AMH). it is a LONG protocol though. I usually stim for 14-18 days after two weeks of priming.

What protocol did you use? That's a ton of eggs for those AFCs.

Anonymous wrote:Dr. Doyle is really nice but he really promotes blast transfer. I don't think he will do a day three transfer-at least with me Plenty of my day 3 transfers didn't work, but i personally would rather go with a chance of a pregnancy as opposed to nothing to transfer. My DS is a day three transfer. I know gw does day three. I'm not sure about the other clinics in the area.

I would look for a 2nd opinion from a doc who wont do a day 3 transfer. When I started doing IVF I could never get pregnant from blast transfers. On round 4 I finally got pregnant from a day 3 transfer when I only had small number of eggs fertilize.

When I went for #2, same problem. They eventually did an ERA that showed my implantation window was a day later than normal (but that was not an option when I started). I think the day 3 transfer worked bc it allowed the blast to develop with my body's timeline. Most of my blasts developed on day 6 and the ERA showed I needed to transfer on day 6.

Dr. Doyle is really nice but he really promotes blast transfer. I don't think he will do a day three transfer-at least with me Plenty of my day 3 transfers didn't work, but i personally would rather go with a chance of a pregnancy as opposed to nothing to transfer. My DS is a day three transfer. I know gw does day three. I'm not sure about the other clinics in the area.

Hi OP.
What did you end up doing? Did you transfer the "fair to poor quality embryos"?
An update would be appreciated, if you are OK talking about it.

I am currently 36 years old, PCOS diagnosis... had 2 egg retrievals last year and made tons of eggs that never made it to blast.
I was wondering which fertility you were attending at the time and also the name of your RE?
I am currently at Shady Grove with Dr. Doyle... I like him a lot but he is not aggressive with decision-making... I wish someone could give me options regarding transferring 3-day embryos..

My past ERs... we waited till day 7 for them to become blasts but they never made it
I have currently started my new cycle and I think they are planning on doing the same.

I would transfer all three at once.

Anonymous wrote:I have the same numbers as you but I'm 40 with a 4 year old child who I got pregnant with right away when I was 35. I have been ttc a sibling for 3 years and no luck but I was told I have mold not severe dor. My afc is 10 maybe that's why

i have a starting AFC of 2-3. For some reason two weeks of estrogen priming before stimming really gets things going for me and I end up with a pretty good haul (For my AMH). it is a LONG protocol though. I usually stim for 14-18 days after two weeks of priming.

I have the same numbers as you but I'm 40 with a 4 year old child who I got pregnant with right away when I was 35. I have been ttc a sibling for 3 years and no luck but I was told I have mold not severe dor. My afc is 10 maybe that's why

Anonymous wrote:How many cells are the day 3 frozens?

. All 10 were between 7-9, most of them 8’s. I have three 8’s and two 7’s left but they all have 15-25 frag. All my zero frag 8 cells were already transferred and zilch.

Anonymous wrote:Why are you considered severe DOR? Because of your AMH?

Yes.

I ovulate like clockwork but clearly my Amh is awful. Was .45 at 34 years old.

How many cells are the day 3 frozens?

Why are you considered severe DOR? Because of your AMH?

Anonymous wrote:And there is a 5% chance of destroying a normal embryo doing PGS testing

There is also a chance they won't defrost. Or they won't implant despite of being PGS normal. The whole process is a bit of a crap shoot, but it does have non-zero chances of success.