Fwiw, I have an amazing healthy girl that I had a 39. I also lost two pregnancies at 12/13 weeks to T21 (TFMR.) I've since done four rounds of IVF, retrieved well over 70 eggs, gotten over 30 to Day 3 -- and only 3 to blast. All three were abnormal.

At 42, I'm moving on to DE. I can't stomach the idea of another chromosomally abnormal pregnancy.

Anonymous wrote:

Anonymous wrote:Since DE are off the table, I'd be happy with your one and only and get on with life.

Yes, I agree with this. I tried IVF 41-42 and gave up. One year later, I went back for DE. I tried to be "one and done," but it wasn't what I/we wanted. The chances of IVF working at our age is extremely slim.

The chances of it working with DE are pretty good aren't they?

I'm confused by your post.

Egg quality at this age, most likely. Only you can answer the question if the small chance of conceiving a healthy child is worth the risk of another couple of early (or late) miscarriages; what if it's a trisomy that doesn't end in miscarriage?

Anonymous wrote:

Anonymous wrote:There are some immune issues that can cause you to miscarry female embryos. So, the miscarriages might all have been females, and the males were the ones you would be able to carry to term.

not to be a buzzkill, but at 44, the likelihood is egg quality not immunity issues.

+1

...and if your RE isn't already talking to you about DEs (even though you are not interested), I'd change REs.

I would keep going.

OP here. I asked my mom about the age when she entered menopause. She did not remember the exact age but she believes it was somewhere between 54~56.

OP how old was your mother when she entered menopause

Anonymous wrote:There are some immune issues that can cause you to miscarry female embryos. So, the miscarriages might all have been females, and the males were the ones you would be able to carry to term.

not to be a buzzkill, but at 44, the likelihood is egg quality not immunity issues.

There are some immune issues that can cause you to miscarry female embryos. So, the miscarriages might all have been females, and the males were the ones you would be able to carry to term.

I'd do it, but I'd try a different RE.

We had the same results over and over again until we switched REs and went to CCRM. We transferred our 6 vials (MF here also) and conceived there

OP back. Thank you, ladies. I am still between the two ideas but for a start, I need to see RE to discuss my recent MC. To the PP who suggested immune blood work if first is a male, why is that? In fact, our first is male and the PGS normal was also male. Any femal blastocyst I had from PGS came back with multiple abnormalities back then.
Having first born male, does that change my body's reaction to any fetus? I guess this would have to be discussed with RE, too. Any other topics I should raise with RE? I've tested all clear on Tyroid, etc.