Anonymous wrote:

Anonymous wrote:I know this is a thread from April of this year but what cause miscarriage typically in a PGS tested embryo? I know they say 60% chance of success but once it's successfully implanted, what could go wrong?

Immune issues maybe?

Must be other stuff too. A lot has to happen for a baby to develop, e.g. the person who had a blighted ovum. I mean if you think about it, even young folks (who likely have genetically normal embryos) who don't do IVF have miscarriages, blighted ovum, ectopic, etc.

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:I know this is a thread from April of this year but what cause miscarriage typically in a PGS tested embryo? I know they say 60% chance of success but once it's successfully implanted, what could go wrong?

Immune issues maybe?

I'm not OP btw but just feeling so devastated about this. How do I know if I have immune issues? My fresh cycle was successful in that I have a DD who is 21 months old.

You have to get testing. There is a basic Recurrent Pregnancy Loss panel that most REs will do, but sometimes not if you've only had one loss. This will pick up on some basic things, like some clotting factor issues. There is more extensive immunological testing, and the only local RE doing it is Dr. Abbasi at CFA. She mentioned that she talked one of her partners into also taking on immunological stuff, but I'm not sure which one.

Anonymous wrote:

Anonymous wrote:I know this is a thread from April of this year but what cause miscarriage typically in a PGS tested embryo? I know they say 60% chance of success but once it's successfully implanted, what could go wrong?

Immune issues maybe?

I'm not OP btw but just feeling so devastated about this. How do I know if I have immune issues? My fresh cycle was successful in that I have a DD who is 21 months old.

Hi OP,

I'm so sorry this happened to you. I had a different situation in which the products of miscarriage were tested afterward and the embryo was found to be chromosomal normal (also after heartbeat, and I also needed a D&C because no signs of miscarrying on my own), so not the same level of expectation and heartbreak, but still so stressful not knowing what caused it. My RE actually did not think that this necessarily meant anything definitive in terms of my ability to carry a healthy pregnancy to term. She said that there were also morphological issues that can occur that the genetic testing does not catch. I had 4 embryos on ice (untested) and went on to have a successful pregnancy and healthy baby at age 42. So try not to despair at this point. I am hoping the best for you!

Anonymous wrote:I know this is a thread from April of this year but what cause miscarriage typically in a PGS tested embryo? I know they say 60% chance of success but once it's successfully implanted, what could go wrong?

Immune issues maybe?

I know this is a thread from April of this year but what cause miscarriage typically in a PGS tested embryo? I know they say 60% chance of success but once it's successfully implanted, what could go wrong?

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:But PGS can pick up mosaics - I just had it done - it's called Next Generation Sequencing- and it picked up one of my 3 abnormals as a mosaic.

Now they can. The microarray PGS that was done a couple of years ago did not detect mosaics.

Correct: but op presumably used the newer technology?

This is OP - thanks everyone. My embryo was frozen May 2016 at SG, and I don't believe they had the Next Gen technology. Now I am concerned about my 2 other "normals" as they are from the same batch.

I have the same worry. We froze 2 embryos tested with the old PGS in May 2015, and are about to embark on FET.

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:But PGS can pick up mosaics - I just had it done - it's called Next Generation Sequencing- and it picked up one of my 3 abnormals as a mosaic.

Now they can. The microarray PGS that was done a couple of years ago did not detect mosaics.

Correct: but op presumably used the newer technology?

This is OP - thanks everyone. My embryo was frozen May 2016 at SG, and I don't believe they had the Next Gen technology. Now I am concerned about my 2 other "normals" as they are from the same batch.

Anonymous wrote:

Anonymous wrote:But PGS can pick up mosaics - I just had it done - it's called Next Generation Sequencing- and it picked up one of my 3 abnormals as a mosaic.

Now they can. The microarray PGS that was done a couple of years ago did not detect mosaics.

Correct: but op presumably used the newer technology?

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:I'm 38 and had a healthy pregnancy - but my IVF doctor told me at my age (37 at the time) about 25% of naturally occurring pregnancies result in miscarriage and about 4% of PGS tested embryos. Sorry for your loss OP.

This information is incorrect. A pgs tested embryo has a 60% chance of live birth. My RE (SG) showed me the stats. That's at any age. Once an embryo is tested, age is no longer a factor. REs should be sharing this info with patients so they can make informed decisions.

I recently had PGS testing done and my RE at SG was clear that your age does affect whether the embryo is normal even if "PGS normal". An older patient is more likely to have an embryo with mosaicism or a microdeletion that the test cannot pick up

I had success with a PGS normal. It is the best we have right now. But it is not perfect as others have said.

Right, older patients have fewer normals. But once you get that normal, the odds are 60% for a live birth--regardless of age.

Anonymous wrote:But PGS can pick up mosaics - I just had it done - it's called Next Generation Sequencing- and it picked up one of my 3 abnormals as a mosaic.

Now they can. The microarray PGS that was done a couple of years ago did not detect mosaics.

But PGS can pick up mosaics - I just had it done - it's called Next Generation Sequencing- and it picked up one of my 3 abnormals as a mosaic.

Anonymous wrote:

Anonymous wrote:I'm 38 and had a healthy pregnancy - but my IVF doctor told me at my age (37 at the time) about 25% of naturally occurring pregnancies result in miscarriage and about 4% of PGS tested embryos. Sorry for your loss OP.

This information is incorrect. A pgs tested embryo has a 60% chance of live birth. My RE (SG) showed me the stats. That's at any age. Once an embryo is tested, age is no longer a factor. REs should be sharing this info with patients so they can make informed decisions.

I recently had PGS testing done and my RE at SG was clear that your age does affect whether the embryo is normal even if "PGS normal". An older patient is more likely to have an embryo with mosaicism or a microdeletion that the test cannot pick up

I had success with a PGS normal. It is the best we have right now. But it is not perfect as others have said.

Anonymous wrote:I'm 38 and had a healthy pregnancy - but my IVF doctor told me at my age (37 at the time) about 25% of naturally occurring pregnancies result in miscarriage and about 4% of PGS tested embryos. Sorry for your loss OP.

This information is incorrect. A pgs tested embryo has a 60% chance of live birth. My RE (SG) showed me the stats. That's at any age. Once an embryo is tested, age is no longer a factor. REs should be sharing this info with patients so they can make informed decisions.

Pp here who mentioned 4%...obviously I don't know what happened to OP, just that unfortunately PGS testing is not a guarantee