If you're talking Bay Area you will take a huge hit in quality of life. Things are so costly there and many, many families are rolling around in tech money (founders, Angels, iPo companies, VCs, bankers). Good luck, do the math on cost of living.
If not Bay Area, enjoy the adventure!
I'm also in a pretty specialized field looking at jobs around the country similar to being a professor. Dh is willing to be a trailing spouse if he can work some part of his job remotely, which we think will be possible. I pulled out of a job process in silicon valley area, however, because we realized that the COL, with 2 kids, and our incomes would just not work. We are considering a move to a smaller town in Mass, where DH could easily get back to DC as needed. So, if I were you, I would consider all factors--not just your own job (important) buta lso the overall picture.
and I LOVE the bay area. But there's no way we would have loved the life we had there.