Anonymous wrote:There's some misunderstanding of the reasons you shouldn't take ibuprofen.
You should not take ibuprofen during the 3rd trimester because that is when the heart chambers are closing. There is evidence that ibuprofen CAN (doesn't mean it always happens) keep the heart from closing properly, so the baby is born with a "hole in the heart" (inside the heart).
Ibuprofen does not increase the risk of miscarriage.
Many OBs will advise against ibuprofen during pregnancy so as not to confuse people, but if you are taking it in the first or second trimester, and as directed, it's fine.
Some evidence from 2008, not particularly strong, suggest asprin and non-steriod anti inflammatory drugs (ibuprofen for example) should be avoided during the first trimester:
Bibliographic details: Nakhai-Pour HR, Berard A. Major malformations after first-trimester exposure to aspirin and NSAIDs. Expert Review of Clinical Pharmacology 2008; 1(5): 605-616.
The authors concluded that exposure to aspirin or NSAIDs during the first trimester of pregnancy was associated with the risk of gastroschisis (aspirin), cardiac malformations (NSAIDs) and orofacial malformations (naproxen). The authors' conclusion reflected the evidence presented. However, due to a lack of validity assessment and reliance upon observational studies, the reliability of the authors conclusions is unclear. Full critical summary