Anonymous wrote:
Anonymous wrote:I am an adult who takes Prozac to manage my anxiety symptoms. Why does it make you nervous?
Because it increases dwell time of serotonin and perhaps other neurotransmitters, in the synapse of the neurons. This causes overexcitement in the brain and anxiety. However over time it will dull the response and damage the neurons, so it then can cause slower brain activity.
Changing the dosage or medication type of SSRI will often cause a reboot of this activity and more neural activity, until the drug does more harm again and settles the neural activity.
Do you have some evidence or cite for the claim that SSRI’s overtime, dull a response and damage, neurons and cause slower brain activity?
The things you say don’t necessarily go together. Increased seratonin in the synapse does not automatically cause “overexcitement in the brain” nor anxiety. Some people who take SSRIs experience an increased level of agitation or anxiety, but these symptoms often go away after a few weeks, and, in fact, are FDA-approved for treating generalized anxiety disorder, panic disorder, OCD, and social anxiety disorder. FDA approved means that clinical trials have shown a meaningful improvement in anxiety for people with these diagnoses.
It is true that SSRI’s can increase or decrease activity in certain brain regions. A decrease in certain brain regions may actually be helpful for someone who is depressed and who is ruminating which can be a reflection of too much brain activity. Continued use of antidepressants leads to new cell growth(by 20-40%) in an area of the brain known to suffer cell death and atrophy as a result of depression and stress. (I see the December 15 article in the journal of neuroscience by Ronald Newman.). Similar cell growth was seen after 14 to 28 days of administration of antidepressants.