Do you have enough money to pay for the move, security deposit and a few months rent, and your necessities until you find a job? And do you have a skill set that is needed in the new location? If so you just rent an apartment, pack your stuff, and go. If you don't have a nest egg it's harder and you need to find a job there first (and save up while you wait--moving is expensive, even if you get rid of lots of stuff and rent a U-Haul you still need boxes, the truck, and replacement stuff). And if you have kids or other dependents or a spouse who also needs to find a new job, it's even more complicated.