Anonymous wrote:

Anonymous wrote:Not necessarily but a hill I will die on is that prescribed 800 mg of Ibuprofen (single pill) is more effective than 4 200 mg of OTC Advil.

I am a dentist, and at a continuing ed class we learned this is true. The 800mg pill is more effective than 4 200’s. No need to die on the hill. You’ve won. 😂

Omg!!! You’ve made my entire week & I’m tempted to print this wallet size and whip it out as proof. Hahaha

Anonymous wrote:Not necessarily but a hill I will die on is that prescribed 800 mg of Ibuprofen (single pill) is more effective than 4 200 mg of OTC Advil.

I am a dentist, and at a continuing ed class we learned this is true. The 800mg pill is more effective than 4 200’s. No need to die on the hill. You’ve won. 😂

YES, there can be important differences between generics and brand names:

1. Inactive ingredients and coating may interact differently with a group of patients and may be less well tolerated by them. The studies done to compare generics and brands are not well funded enough to go into such detail.

2. Generics for daily meds may allow for greater variability in the active ingredient, thus not giving as reliably accurate a daily dose as the brand.

A few years ago in Europe, the manufacturer of a generic thyroid medication, levothyrox, decided to change its inactive ingredients, causing a number of patients to have unwanted side effects. The American brand name Synthroid is not sold in most European countries, and these patients started lawsuits to get the generic formula changed back.

For that same medication, it is well known that Synthroid is more accurately dosed and has less variability between each pill, than its generic.

I never noticed this until a few years ago then my generic Tylenol worked but instead of 6-8 hours would last only 3-5 now the name brand will last 6-8. Either this is how my body is processing it now in my 40's or they are different but I can 10000% tell the generic doesn't last at long.

Anonymous wrote:I know with my sumatriptan for migraines that various generics work differently. Some are twice the size so obviously contain more filler. When I have a migraine I don't digest as well so yes, certain brands behave differently. I'm not saying the active ingredient isn't the same but the way it enters the bloodstream is not identical.

Loose standard

Anonymous wrote:They do what’s called bioequivalence studies to show that the genetic works the same as the brand. So no, it doesnt work better or faster.

Bioequivalence is a lose standard, and more stable polymorphs can arise over time that degrade a factory's output quality.

Anonymous wrote:

Anonymous wrote:They do what’s called bioequivalence studies to show that the genetic works the same as the brand. So no, it doesnt work better or faster.

Yes, on the active ingredient, not on the casing and other ingredients. That was the point of the podcast.

There's no reason why the brand name would be better. Their patent is on the active ingredient.

-*real

Rea Advil works better for me than generic ibuprofen. My gynecologist told me she has found that as well.

No same for Advil and Tylenol for me.