Anonymous wrote:My DD is on amoxicillin, and on day 7 developed a leg rash. She had the same issue twice as a toddler. Online it suggests that amoxicillin rashes happen once in a lifetime and you’re ok the next time you take it. Does anyone have experience with amoxicillin rashes every time it’s taken?

Know several adult relatives that have had major hives rash with anything penicillin related so they do not always grow out of it.

I second going to an allergist. My son developed hives from amoxicillin when he was very young and was marked with penicillin allergy after that. When he turned 18 I took him to an allergist and did the skin and the oral test and he passed so no he is no longer marked as allergic.

Anonymous wrote:

Anonymous wrote:Can you test for this?

Yes, go see an allergist. This thread and the multiple calls for "It's an allergy!" are exactly why you don't get your diagnosis from an anonymous forum.

And the allergist will literally give it to you in the office and see if you react. That's the test.

My son had the rash, then we went to the allergist. They first did a general prick test, then we came back for just the amoxicillin oral challenge.

I understand you're worried that this keeps happening. Again, go to the allergist. It's so worth it knowing either way! (To not contribute to the problem of antibiotic resistance and to not be prescribed a stronger antibiotic when something more basic would do the job - antibiotics can kill healthy gut bacteria too, so might as well stick to the least strong one that works.)

My kids got hives from amoxicillin and one also vomited. They both failed the challenge in the allergist's office. Marked as an allergy for both of them, four years apart. Go get tested.

It is serum sickness.

We avoid amoxicillin because of it. Tested for allergy but no allergy.

Anonymous wrote:Can you test for this?

Yes, go see an allergist. This thread and the multiple calls for "It's an allergy!" are exactly why you don't get your diagnosis from an anonymous forum.

My 6yo had this after an ear infection a few months ago. He’d never reacted before and I was sure it was chicken pox. I took him to dr and she said it was her 3rd or 4th patient of the day with the same issue. Not an allergy but she said we’d avoid for a while before giving it again.

I’m turning 40 this year and got a rash from amoxicillin the last time I took it - my doctors have said we’ll use from now on. I’ve not seen it referred to as a “once in a lifetime” rash before.