Ugh, I have been on Zoloft for anxiety for 5 years and have a stubborn 20 pounds that just doesn't move no matter what I do, and being at a higher dose definitely makes it even harder. Going off Zoloft is not an option so I've just worked on accepting my body and maintaining habits that help me know I'm taking care of myself (the biggest one being lots of exercise since it also helps with my anxiety).