We chose a donor who is a carrier of 2 genetic disorders. Just had to get DH tested to be sure he isn’t a carrier for the same 2. They’re very rare so the likelihood it could ever be a problem is so slim.

Anonymous wrote:You can avoid bipolar?

Some donors I saw had family history of Bipolar depression. My Dh has already in his side of the family so yeah I didn’t want to risk it. Obviously, depression can come out at any time without a family history.

Anonymous wrote:You would only do PGD if there was a 1/4 risk. Not just to screen out carrier status. CF is a recessive disease. Carriers are overall healthy (there are only like incredibly rare exceptions to this). Also newsflash, we all carry several recessive diseases, some of which can be screened for, a lot of which can't. So as long as egg donor isn't a carrier for something your husband carries, it's not an issue. Speak to a genetic counselor.

This. If your husband or sperm donor is not a carrier, it's not an issue. If husband/sperm donor is a carrier, though, I would not.

For example, I got the full Ashkenazi Jewish panel. I am a carrier for Tay-Sachs disease, which was not a surprise as I had two cousins who died from it decades ago before the disease was widely known. So DH got tested but he is not a carrier, so we were fine to TTC without doing PGS. My sister also was tested when they were TTC and was not a carrier so they did not bother to test her husband (half Jewish).

You can avoid bipolar?

Anonymous wrote:No way. There are other donors out there. Infertility robs us of so much, one of the few silver linings is getting to screen for stuff like this. Even if DH isn't a carrier your child could still pass it on.

Your child could only pass on carrier status. Your child's future partner would also have to be a carrier for there to be a risk for your grandchildren. Carriers are healthy.

You would only do PGD if there was a 1/4 risk. Not just to screen out carrier status. CF is a recessive disease. Carriers are overall healthy (there are only like incredibly rare exceptions to this). Also newsflash, we all carry several recessive diseases, some of which can be screened for, a lot of which can't. So as long as egg donor isn't a carrier for something your husband carries, it's not an issue. Speak to a genetic counselor.

Anonymous wrote:Could you do PGS?

I think this is possible. My neighbor's are both carriers of cystic fibrosis; the woman of the couple had a sister who died from it. They did IVF so they could select embryos that did not pass on the disease.

Could you do PGS?

Anonymous wrote:No way. There are other donors out there. Infertility robs us of so much, one of the few silver linings is getting to screen for stuff like this. Even if DH isn't a carrier your child could still pass it on.

Plus 1000

Do you want this or even to pass it along for your child’s heartache.

Yes I would. Being a carrier means nothing, especially if you u are aware. (Assuming the sperm is not from a carrier.)

Absolutely if DH has cystic fibrosis sequencing (including 5T analysis). Bring a carrier is fine.

No way. There are other donors out there. Infertility robs us of so much, one of the few silver linings is getting to screen for stuff like this. Even if DH isn't a carrier your child could still pass it on.

Also to add, we selected a donor who carried a serious disease, but since my husband did not and you need both partners to have the gene. No donor is perfect, but I did avoid auto immune diseases, bipolar, and alcoholism.

I would unless, it only takes one gene to pass on.

The donor is excellent in every way but she is a carrier of Cystic fibrosis. Would you select her or not a good idea.