Anonymous wrote:

Anonymous wrote:OP here. Thanks so much for sharing your stories and experiences. My RE doesn’t think an ERA would be helpful for me, especially in a natural cycle as each cycle is different. I had a normal RPL panel and met with several REs, a hematologist, and a high-risk OB. All seem to be in agreement that it’s just bad luck, as hard as that may be to believe. We recently switched clinics and got a good amount of PGS normal embryos from our first cycle there. We went into it expecting a lot of abnormals given my miscarriage history. I also had a saline sonogram and endometrial scratch/biopsy done this month. Both normal.

For those who may be interested, here’s how my clinic said the natural cycle will go (I’m a CCRM patient): When my period comes, I’ll go in for a suppression check to confirm things look appropriate to transfer. I’ll then return on CD 8 or 9 for another scan. Over the next 3- 10 days after that, I’ll go in for monitoring pretty frequently (possibly daily) to make sure we catch my natural ovulation. When the lead follicle is mature, I’ll trigger with HCG. Two days after that, I’ll start Estradiol, Prometrium, and Medrol. The transfer will be one week post trigger.

First PP here. Yes this sounds similar to what I did as well, including the Medrol (well I was on higher dosages of prednisone but I was actually working with an RI). I wish you the best of luck!

Anonymous wrote:OP here. Thanks so much for sharing your stories and experiences. My RE doesn’t think an ERA would be helpful for me, especially in a natural cycle as each cycle is different. I had a normal RPL panel and met with several REs, a hematologist, and a high-risk OB. All seem to be in agreement that it’s just bad luck, as hard as that may be to believe. We recently switched clinics and got a good amount of PGS normal embryos from our first cycle there. We went into it expecting a lot of abnormals given my miscarriage history. I also had a saline sonogram and endometrial scratch/biopsy done this month. Both normal.

For those who may be interested, here’s how my clinic said the natural cycle will go (I’m a CCRM patient): When my period comes, I’ll go in for a suppression check to confirm things look appropriate to transfer. I’ll then return on CD 8 or 9 for another scan. Over the next 3- 10 days after that, I’ll go in for monitoring pretty frequently (possibly daily) to make sure we catch my natural ovulation. When the lead follicle is mature, I’ll trigger with HCG. Two days after that, I’ll start Estradiol, Prometrium, and Medrol. The transfer will be one week post trigger.

Anonymous wrote:Usually, the less drugs is in reference to stim drugs. If you do a fresh transfer, higher stims can affect the lining negatively.

I'd consider doing an ERA before a truly natural cycle transfer (no drugs). Also, there are different protocols for the transfers. CCRM uses daily PIO and progesterone suppositories with delestrogen. Evidence suggests that PIO is better than suppositories. Low progesterone can cause miscarriage. It doesn't sound like your RE has any reasonable basis for suggesting natural cycle, but just that he/she doesn't know exactly why the prior transfers didn't work.