This must be new. My doctor was one of the lead study docs and OKed my decision to do endometrin inserts. I knew it was a slightly lower live birth rate but didn’t realize it was this much different. We discussed this. Listen to what your doctors are saying now. My info is out of date.

Live birth rate was 40% lower in the endometrin only arm of the study vs the other two arms (daily IMP shot or shot every 3rd day with endometrin). I’ll stick with the shots.

Please read the report of the study linked above instead of following the second-hand reports and anecdotes here. The difference with PIO is large and significant.

Anonymous wrote:

Anonymous wrote:I did a no injection FET at SG. Worked first try. My understanding is that the implantation rate is meaningfully higher with injections but the live birth rate isn’t actually meaningfully higher. So you might have a higher chance of a negative pregnancy test but if you do get a positive, a lower miscarriage rate.

We’re you a Shared Risk patient? Did you specifically ask for a no injection FET? Was there any push back from your RE?

Not a shared risk patient. Yes, I specifically asked. I wouldn’t call it “pusback” but I did have a convo with my doctor and their first recommendation was to do the PIO at least every third day. I said I wanted to try without and they said Ok after informing me of the facts. Very friendly and professional. FWIW I had other frozen embryos so felt like I could take the extra risk. Again though, I think the live birth rate is nearly as good.

I have 2 FET at SGF. My RE said the success rate with PIO is slightly higher. If I insisted on Endometrin, he would let me as well. But he said their research indicated a Slight advantage with PIO. I did PIO and have BFP both times. I did Endometrin for my fresh cycle and it’s not that much easier and opted for one that the RE recommended.

Anonymous wrote:I did a natural cycle FET with SG in September. I opted to use a trigger shot, but it was completely my choice. That was the only injection, and it was a tiny subq one at that. My Re (Beall) told me that the success rates are the same for natural cycle vs. medicated, and that it was up to my husband and I to choose what was right for us. She was very supportive of our choice.

Thanks for sharing! Great to know it’s an option.

Anonymous wrote:I did a natural cycle FET with SG in September. I opted to use a trigger shot, but it was completely my choice. That was the only injection, and it was a tiny subq one at that. My Re (Beall) told me that the success rates are the same for natural cycle vs. medicated, and that it was up to my husband and I to choose what was right for us. She was very supportive of our choice.

Thanks for sharing! Great to know it’s an option.

I did a natural cycle FET with SG in September. I opted to use a trigger shot, but it was completely my choice. That was the only injection, and it was a tiny subq one at that. My Re (Beall) told me that the success rates are the same for natural cycle vs. medicated, and that it was up to my husband and I to choose what was right for us. She was very supportive of our choice.

Anonymous wrote:I did a no injection FET at SG. Worked first try. My understanding is that the implantation rate is meaningfully higher with injections but the live birth rate isn’t actually meaningfully higher. So you might have a higher chance of a negative pregnancy test but if you do get a positive, a lower miscarriage rate.

We’re you a Shared Risk patient? Did you specifically ask for a no injection FET? Was there any push back from your RE?

I did the PIO (injection) every 3rd day and the endomterin (progesterone suppositories) every day in the morning and evening. I ended up miscarrying a pgs normal embryo at 6 weeks but I know it's not from the protocol. However, for my next FET, I'll be only doing PIO (at my request) simply because the Endomterin suppositories (2 in the am and pm) were just nasty and I hated wearing a pad all the time.

I did a no injection FET at SG. Worked first try. My understanding is that the implantation rate is meaningfully higher with injections but the live birth rate isn’t actually meaningfully higher. So you might have a higher chance of a negative pregnancy test but if you do get a positive, a lower miscarriage rate.

I've done 2 FETs with a no injection protocol at SG, using estrace and Crinone. BFP from both, although only one was ultimately successful. The loss was not correlated to the FET protocol. I'll be doing another FET early next year using the same protocol, since it works for me.

They prefer using the injections because it leads to higher success rates, based on their research https://www.prweb.com/releases/shady_grove_fertilitys_landmark_research_study_earns_asrms_top_scientific_congress_prize_paper_award_for_clinical_significance/prweb15911466.htm

I believe with a shared risk program it is required. I asked if I could do suppositories because I really don't want PIO and my doctor indicated that they have seen significant higher success in pio, however they saw no difference in success rates of pio every day versus pio every 3 days, supplemented by pills on non injection days and therefore you can opt for that option.
If it isn't shared risk, you may be able to do natural, not sure.

Anyone had experience with no injections FET protocol with SG? I heard that injections are the default but sometimes they allow you to do no injection protocol if asked. Wanted to see if anyone had any experience to share. Thanks!