Anonymous wrote:I would. But I had T21 pregnancies at 38 and 41.

PGS is supposed to screen for this, though.

I think the miscarriage rates for CVS and amino are 0.5-1%? But ideally you’d go to a doctor who has done hundreds or thousands without more than 1 or 2 bad events over a whole career, right?

I would. But I had T21 pregnancies at 38 and 41.

Anonymous wrote:

Anonymous wrote:All diagnostic test have a risk of MC. Are you willing to take that risk?

I know someone in a group I'm in that had a PGS tested embryo so forgo any blood tests (only the nuchal screening) and it turned out to have one of the Trisonomies. Terminated (or it died in utero, I can't remember) in the early 20's weeks.

So how did she end up with a Trisomy? Was PGS wrong?

I'm not the PP, but PGS doesn't catch everything. I had a triploid, which is a third copy of every chromosome, so 69XX. I was told that PGS would not have picked this up because it looks for balance. When you have a trisomy on an individual chromosome, there is an imbalance that can be detected, but when every chromosome has an extra, it is not out of balance as a whole. That pregnancy went to 11 weeks, and that mutation can go into the second trimester, as well.

What is the current miscarriage risk for CVS? When exactly is it done? Is it more or less risk than amnio?

no, i wouldn't. i would do a harmony or maternity21 test.

Anonymous wrote:If I had done PGS I would probably just do the blood tests - not CVS or amino, unless something turned up.

Which blood test would that be?

Anonymous wrote:All diagnostic test have a risk of MC. Are you willing to take that risk?

I know someone in a group I'm in that had a PGS tested embryo so forgo any blood tests (only the nuchal screening) and it turned out to have one of the Trisonomies. Terminated (or it died in utero, I can't remember) in the early 20's weeks.

So how did she end up with a Trisomy? Was PGS wrong?

Anonymous wrote:All diagnostic test have a risk of MC. Are you willing to take that risk?

I know someone in a group I'm in that had a PGS tested embryo so forgo any blood tests (only the nuchal screening) and it turned out to have one of the Trisonomies. Terminated (or it died in utero, I can't remember) in the early 20's weeks.

I had CVS with both of my children with no issues, so I am not that concerned about CVS-related MC. At that point in time, it's difficult to separate CVS risks from the regular MC risk.

All diagnostic test have a risk of MC. Are you willing to take that risk?

I know someone in a group I'm in that had a PGS tested embryo so forgo any blood tests (only the nuchal screening) and it turned out to have one of the Trisonomies. Terminated (or it died in utero, I can't remember) in the early 20's weeks.

THanks, everyone. I have a bias against screening test so if I do do something, I would do a diagnostic test, not screening.

If I had done PGS I would probably just do the blood tests - not CVS or amino, unless something turned up.

I didn't do any other tests except for the 12 week scan and the 16 week blood test for spina bifida.

maternit21 and similar will give you the same info as PGS I think. CVS and amnio can give you much more info. NT and later us scans also give you different info than PGS.

At 10 weeks you can do one of several non-invasive blood tests that will give you a little more information--Harmony, MaterniT21, etc.

Want to get some advice to make a better decision. I'm currently 10 weeks pregnant with a PGS-tested embryo. What genetic testing should I choose, if any? As I understand it, any genetic testing in this case would be to essentially double-check the PGS results for margin of error. If it matters, I'm 44, and this embryo was produced when I was 41. Third pregnancy, all healthy so far. What would you do?