Anonymous wrote:Since DE are off the table, I'd be happy with your one and only and get on with life.

Yes, I agree with this. I tried IVF 41-42 and gave up. One year later, I went back for DE. I tried to be "one and done," but it wasn't what I/we wanted. The chances of IVF working at our age is extremely slim.

Anonymous wrote:What does your RE say about the repetitive early miscarriages? If you really want another child I'd move on to DE, unless you specifically do not want that option.

If the issue is the husband's sperm, wouldn't they move to DS?

Frankly, I'd tray donor sperm before I tried IVF, simply because it's easier and cheaper.

I would do it OP. THough I would probably try to investigate anything that might be contributing to the multiple miscarriages.

Good luck.

Since DE are off the table, I'd be happy with your one and only and get on with life.

NP - agree that if money isn't a factor, you should consider getting some immune blood work done, especially if your child is a male.

Anonymous wrote:I would probably do it and quickly. Otherwise you might be having second thoughts at 46 or something

I agree with this. It seems as if you would always think "what if" about those last 2 vials. Good luck!

I would probably do it and quickly. Otherwise you might be having second thoughts at 46 or something

Are you willing to go through two more miscarriages?

Ask your odds of conceiving--it seems awfully slim.

In your place, I would be doing my best to be glad for what I already had and planning some special experiences with my family of three.

Anonymous wrote:
So the other 3 MCs were not PGS tested?

I would go for it since cost is not a factor.

OP back. Of the 4 MC, one was from a day5 blastocyst (inconclusive after PGS, same batch as the normal one) and other three were from the untested cleaving embryos. With aging, I produced less and less eggs and it became too risky to wait until day5, so RE and we agree to freeze everything that were viable on day2 or day3 and transfer those via FET later. Most of the cleaving embryos had the text book appearance (no fragmentation, even and round blastomeres, etc.), so by the look of it, they all looked promising. Our first child was actually a result of untested day2-4cell cleaving embryo via fresh transfer (and this day2 embryo was really a text book beauty), so I was really hopeful of the cleaving embryo transfer albeit my age (I know my egg is not young anymore).

Anonymous wrote:OP here. Good question. Of the 4 MC, one is confirmed genetic abnormality (trisomy 17), but we don't know the cause of other 3 MC as we could not test the product of conception (I suspect genetic abnormality though). I really don't know why the PGS normal did not implant back then...

So the other 3 MCs were not PGS tested?

I would go for it since cost is not a factor.

OP here. Good question. Of the 4 MC, one is confirmed genetic abnormality (trisomy 17), but we don't know the cause of other 3 MC as we could not test the product of conception (I suspect genetic abnormality though). I really don't know why the PGS normal did not implant back then...

I'm sorry it has been so hard. If cost were not a factor (it is for us) I'd try with the two more vials, but can you have an immunology eval done to determine why you keep miscarrying? Best of luck to you whatever you decide.

I forgot to include that this with OE and if it did not work out, we are fine with just single child. Not planning on DE.

What does your RE say about the repetitive early miscarriages? If you really want another child I'd move on to DE, unless you specifically do not want that option.

I will be 44 in roughly two months and ICSI-IVF is our only chance to conceive. DH has obstructive azoospermia (missing the pipe to deliver his sperm).
We fortunately have one child from our very first ICSI-IVF five years ago. We have been trying for a sibling since I was 40 (even then I was not that young, I admit that). In the past almost 4 years, I had six ICSI-IVF under my belt with one fresh transfer and five FET, which resulted in one chemical and four BFP (but all of them ended in early MC between 6wk~7wks). I don't seem to have any implantation issue and I was able to produce one PGS normal day5 blastocyst once (when I was 40, but it did not take). We do not have to worry about the cost as our insurance covers most except for a minor co-pay. And there is just that two vials left if we decide to proceed.

Since the treatment cost is not an issue for us and there is only two vials left (DH is not comfortable going thru another sperm aspiration), part of me says "it is just two more tries so why not", but another part of me says "you have one healthy loving child, it's time to move on."
I am torn between, will you continue or stop?