PP with GW/vaginal progesterone back. RE is fine with this plan, I think, because I had my DS with only the vaginal progesterone support last time. Also at GW.

Although there wasn't a sufficient inferiority signal to warrant immediately un-blinding the PIO everyday vs. PIO every third day groups, I'd stick with PIO everyday to be safe.

PIO everyday, absolutely.

Anonymous wrote:

Anonymous wrote:A very recent randomized controlled trial (done at SGF itself!) showed vaginal progesterone alone was inferior to PIO. http://www.fertstert.org/article/S0015-0282(17)30776-8/abstract

This says that the vaginal suppositories alone are inferior to both the PIO every day group and the PIO every third day + vaginal estrogen every day group.

My doctor told me that this group was getting equivalent results to the PIO every day group, at the same time that she urged me to switch from PIO every third day to PIO every day. This seems like mixed messages, and I wasn't given a reason for that. I'd prefer not to do shots every day (low pain tolerance), but I'd do it if the results were not equivalent. Given that I was told that they were equivalent, what would you do?

PIO everyday.

Anonymous wrote:

Anonymous wrote:A very recent randomized controlled trial (done at SGF itself!) showed vaginal progesterone alone was inferior to PIO. http://www.fertstert.org/article/S0015-0282(17)30776-8/abstract

This says that the vaginal suppositories alone are inferior to both the PIO every day group and the PIO every third day + vaginal estrogen every day group.

My doctor told me that this group was getting equivalent results to the PIO every day group, at the same time that she urged me to switch from PIO every third day to PIO every day. This seems like mixed messages, and I wasn't given a reason for that. I'd prefer not to do shots every day (low pain tolerance), but I'd do it if the results were not equivalent. Given that I was told that they were equivalent, what would you do?

To clarify, I was told that the PIO every third day + vaginal progesterone group was getting results equivalent to the PIO every day group.

Anonymous wrote:A very recent randomized controlled trial (done at SGF itself!) showed vaginal progesterone alone was inferior to PIO. http://www.fertstert.org/article/S0015-0282(17)30776-8/abstract

This says that the vaginal suppositories alone are inferior to both the PIO every day group and the PIO every third day + vaginal estrogen every day group.

My doctor told me that this group was getting equivalent results to the PIO every day group, at the same time that she urged me to switch from PIO every third day to PIO every day. This seems like mixed messages, and I wasn't given a reason for that. I'd prefer not to do shots every day (low pain tolerance), but I'd do it if the results were not equivalent. Given that I was told that they were equivalent, what would you do?

A very recent randomized controlled trial (done at SGF itself!) showed vaginal progesterone alone was inferior to PIO. http://www.fertstert.org/article/S0015-0282(17)30776-8/abstract

NP and I am GW. No BC, No Lupron for me.
1. Go in for baseline blood work on sono on Day2 of my menstrual cycle.
2. Start oral estrace on Day3, 3 times/day.
3. Go in for another blood work about 14 days after start of estrace to check for the desired hormone level & lining.
4. Start vaginal progesterone as instructed
5. Go in for the transfer either 2/3/4/5 days (depends on the stage of your embryo) after your progesterone start date.
6. Beta check after 2 weeks?

I am at GW. I can't recall my exact protocol for my first FET in 2015 that resulted in DD. I know on that cycle I did use birth control pills for a few weeks but this cycle I have not. I am currently in an FET cycle that looks like this:

-Cycle day 10, start monitoring for ovulation using OPK's
-4 days after ovulation occurs, start 20 units of Lupron injections (what I am doing now)
-9 days after starting Lupron - bloodwork and sono
-If all looks good, start estrogen patches and stay on lupron
-10 days later, blood work and sono
-If all looks good, stay on estrogen and start progesterone inserts
-Week later --> transfer

It's basically this calendar, although there appear to be fewer monitoring/blood work appointments in my cycle than indicated on the calendar:

http://www.advancedfertility.com/frozen-embryo-transfer.htm

I know that the rationale behind PIO over Crinone or other vaginal progesterone is that PIO is the only way that it can be measured in the bloodwork. But what about the injectable estrogen? It seems like when I've been on oral Estrace for estrogen priming, they say they can measure it in my blood.

I am with Shady Grove and did this recently. Their protocol is all about injections now: Delestrogen every third day (not covered by insurance, I paid about $94 in Acuria Pharmacy in Falls Church); after six shots (18 days), I did blood work and started daily PIO (covered by insurance, paid 10 dollars for 30 day) for six days. On the sixth day, I did the transfer. I didn't like the PIO shots at all and asked if I could do Crinone 8% instead. I was told that after the transfer, I could start crinone 8% twice a day but every third day I still need to PIO and Delestrogen. Still it's way better than doing PIO daily.

My colleague who is with Shady Grove too pushed for a no needle protocol and she ended up having estradial valerate (insert vaginally twice a day, covered by insurance) instead of Delestrogen. I wish I had known early! She had her blood work and the lining was fine. She had to do the six PIO shots too but after the transfer, crinone 8% plus PIO every third day (and the estradiol insert vaginally twice a day).

Good luck to you!

I had no injectibles. I was on BC for three weeks prior, then started estrace vaginally twice a day on day 3. Added crinone twice a day on day 12. Transfer of single embryo on day 17. BFP. I continued estrace and crinone until 10-11 weeks. Successful pregnancy - DD is now over 18 months old and we are starting to talk about going back for another FET, where I plan on requesting the same protocol.

I did .2 mL of estradiol injections every other day + 1 mL of PIO injections daily. FET was successful.

I'm interested in this also. It seems clinics vary on the form of progesterone and estrogen, when to start, how much, etc. I want to request my doctor to follow a protocol with the best chance of success (e.g. PIO instead of endometrin).

What was/is your FET protocol: which medications and how much, which blood tests and when? Thanks.