We did a train from Zurich to Lausanne, stopping in Lucerne, Interlaken, and another place in forgetting. Lots of amazing views, good food, and takes you from the German to French side so you can see it all. Definitely pricey but worth it. Different enough from Lake Como to consider doing both.
This sounds good to me, OP. I didn't do the trip in this manner, but I have been to Lucerne and Interlaken. I'm thinking that the ski resort of Grindelwald may be the place that PP cannot recall. It is very close to Interlaken. Interlaken is more of a summer resort.
Lucerne is lovely and is a lake town. Grindelwald is a mountain town. If I were you, I would limit the trip to Switzerland-there's plenty to see. November may be pretty cool there, though. I'm more of a slow traveler--stop and smell the roses and enjoy the ambiance.